| 1. |
- Bucardo, Filemon, et al.
(författare)
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Genetic susceptibility to symptomatic norovirus infection in Nicaragua. : norovirus susceptibility in Nicaragua
- 2009
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Ingår i: Journal of medical virology. - : Wiley. - 1096-9071 .- 0146-6615. ; 81:4, s. 728-35
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Tidskriftsartikel (refereegranskat)abstract
- Host genetic resistance to Norovirus (NoV) has been observed in challenge and outbreak studies in populations from Europe, Asia, and USA. In this study, we have investigated if histo-blood group antigens can predict susceptibility to diarrhea caused by NoV in Nicaragua, Central America, and if this can be reflected in antibody-prevalence and titer to NoV among individuals with different histo-blood group antigen phenotypes. Investigation of 28 individuals infected with NoV and 131 population controls revealed 6% of non-secretors in the population and nil non-secretors among patients infected with NoV, suggesting that non-secretors may be protected against NoV disease in Nicaragua. Surprisingly, 25% of the population was Lewis negative (Le(a-b-)). NoV infections with genogroup I (GI) and GII occurred irrespective of Lewis genotype, but none of the Lewis a positive (Le(a + b-)) were infected. The globally dominating GII.4 virus infected individuals of all blood groups except AB (n = 5), while the GI viruses (n = 4) infected only blood type O individuals. Furthermore, O blood types were susceptible to infections with GI.4, GII.4, GII.7, GII.17, and GII.18-Nica viruses, suggesting that secretors with blood type O are susceptible (OR = 1.52) and non-secretors resistant. The overall antibody-prevalence to NoV GII.3 VLP was 62% with the highest prevalence among blood type B carriers (70%) followed by A (68%) and O (62%). All four investigated individuals carrying blood type AB were antibody-negative. Among secretors, 63% were antibody-positive compared to 33% among non-secretors (P = 0.151). This study extends previous knowledge about the histo-blood group antigens role in NoV disease in a population with different genetic background than North American and European.
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| 2. |
- Laux, Timothy S, et al.
(författare)
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Nicaragua revisited : evidence of lower prevalence of chronic kidney disease in a high-altitude, coffee-growing village
- 2012
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Ingår i: JN. Journal of Nephrology (Milano. 1992). - : SAGE Publications. - 1121-8428 .- 1724-6059. ; 25:4, s. 533-540
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Chronic kidney disease (CKD) is found at epidemic levels in certain populations of the Pacific Coast in northwestern Nicaragua especially in younger men. There are knowledge gaps concerning CKD's prevalence in regions at higher altitudes.METHODS: A cross-sectional study of adults between the ages of 20 and 60 years in 1 coffee-growing village in Nicaragua located at 1,000 m above sea level (MASL) altitude was performed. Predictors included participant sex, age, occupation, conventional CKD risk factors and other factors associated with CKD suggested by previous surveys in Central America. Outcomes included serum creatinine (SCr) values >1.2 mg/dL for men and >0.9 mg/dL for women, estimated glomerular filtration rate (GFR) <60 ml/min per 1.73 m2, dipstick proteinuria stratified as microalbuminuria (30-300 mg/dL) and macroalbuminuria (>300 mg/dL), hypertension and body mass index.RESULTS: Of 324 eligible participants, 293 were interviewed (90.4%), and 267 of those received the physical exam (82.4% overall). Of the sample, 45% were men. Prevalence rate of estimated GFR <60 ml/min per 1.73 m2 was 0 for men (0%) and 2 for women (1.4%). The prevalence of at least microalbuminuria was significantly higher among men compared with women (27.5% vs. 21.4%, respectively; p=0.02).CONCLUSIONS: The CKD prevalence in this village is comparable to a previously studied Nicaraguan coffee-farming region and much lower than previously screened portions of northwestern Nicaragua. There is heterogeneity in CKD prevalence across Nicaragua. At this time, screenings should target individuals living in previously identified, higher risk regions. More work is needed to understand determinants of CKD in this resource-poor nation.
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| 3. |
- Ziaei, Shirin, et al.
(författare)
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Women´s autonomy and social support and their associations with infant and young child feeding and nutritional status : community-based survey in rural Nicaragua
- 2015
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Ingår i: Public Health Nutrition. - 1368-9800 .- 1475-2727. ; 18:11, s. 1979-1990
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo evaluate the associations of women’s autonomy and social support with infant and young child feeding practices (including consumption of highly processed snacks and sugar-sweetened beverages) and nutritional status in rural Nicaragua.DesignCross-sectional study. Feeding practices and children’s nutritional status were evaluated according to the WHO guidelines complemented with information on highly processed snacks and sugar-sweetened beverages. Women’s autonomy was assessed by a seventeen-item questionnaire covering dimensions of financial independence, household-, child-, reproductive and health-related decision making and freedom of movement. Women’s social support was determined using the Duke-UNC Functional Social Support Questionnaire. The scores attained were categorized into tertiles.SettingLos Cuatro Santos area, rural Nicaragua.Subjects A total of 1371 children 0–35 months of age.ResultsChildren of women with the lowest autonomy were more likely to be exclusively breast-fed and continue to be breast-fed, while children of women with middle level of autonomy had better complementary feeding practices. Children of women with the lowest social support were more likely to consume highly processed snacks and/or sugar-sweetened beverages but also be taller.ConclusionsWhile lower levels of autonomy and social support were independently associated with some favourable feeding and nutrition outcomes, this may not indicate a causal relationship but rather that these factors reflect other matters of importance for child care.
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| 4. |
- Mendoza, J. A., et al.
(författare)
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Assessment of groundwater vulnerability in the Rio Artiguas basin, Nicaragua
- 2006
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Ingår i: Environmental Geology. - : Springer Science and Business Media LLC. - 0943-0105 .- 1432-0495. ; 50:4, s. 569-580
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Tidskriftsartikel (refereegranskat)abstract
- The Rio Artiguas basin in central Nicaragua shows a distinctive case of environmental deterioration due to anthropogenic activities. Heavy metals used in gold mining and other wastes are continuously released into the rivers, representing a threat to the water quality. This article aims to evaluate the groundwater intrinsic vulnerability in the Rio Artiguas basin and to provide information for sustainable use of water resources. The DRASTIC and GOD methods were used to analyse the relative pollution potential within the basin. DRASTIC was modified to include the degree of influence that geological structures have on the vulnerability. Moderate vulnerability areas cover most of the basin along stream valleys and lowlands, increasing downstream in the basin. The resulting vulnerability maps show that the limited groundwater resources are susceptible to surface water pollution as high vulnerability areas converge along the river valleys.
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| 5. |
- Nilsson, Manuela, 1961-
(författare)
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Grassroots Reconciliation Stories from Post-Conflict Nicaragua
- 2010
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Ingår i: Social Alternatives. - Australia : University of the Sunshine Coast. - 0155-0306. ; 29:1, s. 49-54
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Tidskriftsartikel (refereegranskat)abstract
- How do actors formerly involved in violent conflict reconcile, particularly in the absence of a government-led top down effort? This article analyzing grassroots reconciliation efforts during the fifteen years following the civil war of the 1980s in Nicaragua. As a result of extensive rounds of interviews with actors and opinion leaders from both sides as well as members of the international community in volved in the peace building process, the study concludes that today, after two decades of peace, many Nicaraguans have advanced from negative coexistence to full reconciliation. Faced with the absence of effective ‘trickle down’ policies on the elite level to help this process along, Nicaraguans have found their own ways of reconciliation. Examples for both, the successes as well as the failures to reach reconciliation, are presented.
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| 6. |
- Espinoza, F., et al.
(författare)
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Shifts of rotavirus G and P types in Nicaragua - 2001-2003
- 2006
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Ingår i: The Pediatric Infectious Disease Journal. - : Ovid Technologies (Wolters Kluwer Health). - 0891-3668 .- 1532-0987. ; 25:11, s. 1078-1080
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Tidskriftsartikel (refereegranskat)abstract
- The present study reports the diversity of rotavirus strains circulating in León, Nicaragua during three years. There was a shift of G and P genotypes with increment of one specific genotype during the second most important peak of diarrhea occurring in the beginning of every year. © 2006 Lippincott Williams & Wilkins, Inc.
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| 7. |
- Schmeer, Kammi K., et al.
(författare)
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Maternal resources and household food security : evidence from Nicaragua
- 2015
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Ingår i: Public Health Nutrition. - 1368-9800 .- 1475-2727. ; 18:16, s. 2915-2924
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Women (especially mothers) are theorized as critical to reducing household food insecurity through their work and caregiver roles. The present study tests these assumptions, assessing how maternal economic and social resources are associated with food insecurity in households with young children. Design: Data from a population-based sample of households was collected in Leon, Nicaragua (n 443). Data include a newly validated measure of household food insecurity (ELCSA), maternal resource measures, and household economic status and demographics. Regression analysis tests the statistical associations (P<0.05) of maternal resources with household, adult-specific and child-specific food insecurity. Setting: Municipality of Leon, Nicaragua. Subjects: Households with children aged 3-11 years in rural and urban Leon. Results: Only 25 % of households with young children were food secure, with 50 % mildly food insecure and 25 % moderately/severely food insecure. When mothers contributed substantially to household income, the odds of moderate/severe household food insecurity were 34 % lower than when their spouse/partner was the main provider. The odds of food insecurity were 60 % lower when mothers managed household money, 48 % lower when mothers had a secondary (v. primary) education, 65 % higher among single mothers and 16 % lower with each indicator of social support. Results were similar for adult-and child-specific food insecurity. Conclusions: This research provides new evidence that maternal economic and social resources are important for reducing household food insecurity and adult- and child-specific food insecurity. Women's social status, social support and access to economic resources need to be enhanced as a part of policies aimed to reduce food insecurity in high-poverty settings.
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| 8. |
- Alm, Erika, 1975, et al.
(författare)
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Parenting the nation : state violence and reproduction in Nicaragua and Sweden
- 2023
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Ingår i: Struggles for reproductive justice in the era of anti-genderism and religious fundamentalism. - London : Palgrave Macmillan. - 9783031312595 - 9783031312625 - 9783031312601 ; , s. 213-240
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Bokkapitel (refereegranskat)abstract
- Reproduction is a core question for the state, a site of struggle between the reproduction of the nation and the reproduction of liveable lives, especially for those citizens whose rights are rarely recognized in the first place. What role does the exceptionalisation of reproductive rights play in the reproduction of the nation-state? Nicaragua and Sweden are countries where debates about reproductive justice highlight tensions in the projection of a state that cares for its citizens. Nicaragua, the second-poorest country in the Western hemisphere with one of the most repressive and punitive legislations on abortion in the world. Sweden with its reputation as a pioneering nation in matters of gender equality and reproductive justice. This chapter draws on a particular formulation of the centrality of the state in theories and practices of reproductive justice: the notion of the state as a parent with a particular responsibility to protect and foster, but also discipline and subjugate, its citizens. Political leaders, Fathers and Mothers of the Nation, form the discourse within which the state regulates its imagined children’s, the citizens, reproductive rights. As such the governance of reproduction is a vital aspect of the political fantasy about the nation-state and its futuriority.
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| 9. |
- Lebbad, Marianne, et al.
(författare)
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Dominance of Giardia assemblage B in León, Nicaragua.
- 2008
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Ingår i: Acta Tropica. - : Elsevier BV. - 0001-706X .- 1873-6254. ; 106:1, s. 44-53
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Tidskriftsartikel (refereegranskat)abstract
- Giardiasis is a major problem in León, Nicaragua, yet despite this no data are available regarding the prevalence of different Giardia genotypes in this area. To address this question, a molecular analysis of Giardia isolates from humans and dogs living in the same area in León, Nicaragua was performed. Giardia isolates from 119 Nicaraguan patients and 8 dogs were successfully genotyped using single and/or nested beta-giardin PCR with subsequent restriction length fragment polymorphism (RFLP) analysis. The analyses of human samples yielded 94 (79%) assemblage B isolates and 25 (21%) assemblage A isolates. Only the non-human-associated assemblages C and D were found in the dog samples. Sixteen isolates with assemblage A pattern, 26 isolates with assemblage B pattern and all dog isolates were further characterized by sequencing the nested beta-giardin PCR product and by molecular analyses of the glutamate dehydrogenase (gdh) gene. Within the study area the assemblage A isolates were highly genetically homogenous, showing only sub-genotypes A2 (n=3) or A3 (n=13) at the beta-giardin locus and AII only at the gdh locus while assemblage B showed a high genetic polymorphism at both loci. Seven different sub-genotypes were identified within 13 of the sequenced assemblage B beta-giardin isolates. The remaining 13 sequenced assemblage B-isolates appeared to contain several different variants of the beta-giardin gene since the chromatograms displayed one to seven double peaks. The gdh sequences showed an even higher polymorphism since only 2 of 26 assemblage B isolates were without double peaks. Two mixed infections between assemblage A and B were found when the gdh gene was analyzed. Polymorphisms were also observed in the dog-associated assemblages C and D, but to a lesser extent than in assemblage B.
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| 10. |
- Corriols, Marvin, et al.
(författare)
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Geophysical characterization of the Leon-Chinandega aquifer, Nicaragua
- 2008
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Ingår i: Hydrogeology Journal. - : Springer Science and Business Media LLC. - 1431-2174 .- 1435-0157. ; 16:2, s. 349-362
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Tidskriftsartikel (refereegranskat)abstract
- Electrical geophysical surveys in the mode of vertical electrical soundings (VES) and continuous vertical electrical soundings (CVES) were conducted in the Leon-Chinandega plains, northwestern Nicaragua, in order to obtain detailed information about the geometry of the different hydrogeological layers in the aquifer and depth to the basement. A total of 51 VES were carried out within the plains. The results show a complex structure towards the north east of the area, and the southwestern part of the plains presents a smoother stratification. The geoelectrical measurements and borehole information indicate that the basement topography is characterized by hills and deep valleys with highly variable basement depths. Fifty CVES where done in a smaller area in the center of the plain. The resistivity data yielded considerable information revealing the existence of two main geo-electrical units. The combined interpretation of geological and geophysical data shows an environment typical of sedimentary volcanic coastal plains. The information collected during this investigation provides valuable data for estimating the fresh-water resources of the Leon-Chinandega aquifer system and for development of a groundwater management plan.
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