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Numrering	Referens	Omslagsbild	Hitta
1.	Colombo, Stefan, et al. (författare) Matrix effects in nilotinib formulations with pH-responsive polymer produced by carbon dioxide-mediated precipitation 2015 Ingår i: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 494:1, s. 205-217 Tidskriftsartikel (refereegranskat)abstract Factors determining the pH-controlled dissolution kinetics of nilotinib formulations with the pH-titrable polymer hydroxypropyl methylcellulose phthalate, obtained by carbon dioxide-mediated precipitation, were mechanistically examined in acid and neutral environment. The matrix effect, modulating the drug dissolution, was characterized with a battery of physicochemical methodologies, including ToF-SIMS for surface composition, SAXS/WAXS and modulated DSC for crystallization characterization, and simultaneous UV-imaging and Raman spectroscopy for monitoring the dissolution process in detail. The hybrid particle formulations investigated consisted of amorphous nilotinib embedded in a polymer matrix in single continuous phase, displaying extended retained amorphicity also under wet conditions. It was demonstrated by Raman and FTIR spectroscopy that the efficient drug dispersion and amorphization in the polymer matrix were mediated by hydrogen bonding between the drug and the phthalate groups on the polymer. Simultaneous Raman and UV-imaging studies of the effect of drug load on the swelling and dissolution of the polymer matrix revealed that high nilotinib load prevented matrix swelling on passage from acid to neutral pH, thereby preventing re-precipitation and re-crystallization of incorporated nilotinib. These findings provide a mechanistic foundation of formulation development of nilotinib and other protein kinase inhibitors, which are now witnessing an intense therapeutic and industrial attention due to the difficulty in formulating these compounds so that efficient oral bioavailability is reached.
2.	Moons, Philip, 1968 (författare) Transfer and transition: State of an art in progress 2016 Ingår i: Danish Organisation of Adolescent Health. 4 March 2016. Copenhagen, Denmark. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
3.	Moons, Philip, 1968 (författare) Transfer and transition: Where to go from here? 2016 Ingår i: Summer course on children and adolescents with chronic illness. 30 August - 2 Sept 2016. Lausanne, Switzerland. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
4.	Moons, Philip, 1968 (författare) Transfer and transition: From eminence-based to evidence-based practice 2016 Ingår i: Pentalfa: Interactive Postgraduate Course, Leuven Belgium - 8 December 2016. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
5.	Edvardsson, Bo, et al. (författare) Service Design : A TQM Instrument for Service Providers 1992 Konferensbidrag (refereegranskat)
6.	Moons, Philip, 1968 (författare) Transition in care: Evaluating complex interventions and translating the MRC framework for complex interventions 2019 Ingår i: University of Technology Sydney, Sydney, Australia. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
7.	Moons, Philip, 1968, et al. (författare) Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of Cardiovascular Nursing and Allied Professions (ACNAP), the ESC Working Group on Adult Congenital Heart Disease (WG ACHD), the Association for European Paediatric and Congenital Cardiology (AEPC), the Pan-African Society of Cardiology (PASCAR), the Asia-Pacific Pediatric Cardiac Society (APPCS), the Inter-American Society of Cardiology (IASC), the Cardiac Society of Australia and New Zealand (CSANZ), the International Society for Adult Congenital Heart Disease (ISACHD), the World Heart Federation (WHF), the European Congenital Heart Disease Organisation (ECHDO), and the Global Alliance for Rheumatic and Congenital Hearts (Global ARCH) 2021 Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 42:41 Tidskriftsartikel (refereegranskat)abstract The vast majority of children with congenital heart disease (CHD) in high-income countries survive into adulthood. Further, paediatric cardiac services have expanded in middle-income countries. Both evolutions have resulted in an increasing number of CHD survivors. Expert care across the life span is necessitated. In adolescence, patients transition from being a dependent child to an independent adult. They are also advised to transfer from paediatrics to adult care. There is no universal consensus regarding how transitional care should be provided and how the transfer should be organized. This is even more challenging in countries with low resources. This consensus document describes issues and practices of transition and transfer of adolescents with CHD, accounting for different possibilities in high-, middle-, and low-income countries. Transitional care ought to be provided to all adolescents with CHD, taking into consideration the available resources. When reaching adulthood, patients ought to be transferred to adult care facilities/providers capable of managing their needs, and systems have to be in place to make sure that continuity of high-quality care is ensured after leaving paediatric cardiology.
8.	Klemedtsson, Åsa Kasimir, 1956, et al. (författare) Nitrous oxide emissions and nitrogen use efficiency 2005 Ingår i: Focus on soils Symposium. Managing soils for the future.. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
9.	Eriksson, Sune, 1954- (författare) Acrylamide in food products : Identification, formation and analytical methodology 2005 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract The aim of this thesis was to verify the indicated occurrence of acrylamide formation in heating of food, to identify factors affecting the formation, and to identify important sources of acrylamide exposure from food. As a prerequisite for the studies, gas- and liquid-chromatographic methods with mass spectrometric detection were developed for the analysis of acrylamide in food. The developed methods showed a high correlation coefficient (0.99), high sensitivity and reproducibility. Acrylamide was demonstrated to occur in heated food products, with unexpectedly high levels in potato products (up to mg/kg level in potato crisps) and in beetroot. The identity of acrylamide was confirmed by the developed methods. With potato as a food model, different factors affecting the acrylamide formation were tested. It was shown that the addition of asparagine and fructose, as well as heating temperature and time had a large impact on the formation. Other factors affecting the acrylamide content were pH, addition of other amino acids apart from asparagine, protein and other reducing sugars. No significant effects were observed from addition of neither antioxidant nor radical initiators. It was discovered that acrylamide could be formed during heating of biological materials similar to food, also at temperatures below 100 ˚C. Furthermore, it was demonstrated that a fraction of acrylamide evaporates during heating, similar to conditions for cooking in household kitchens, and during dry matter determinations in laboratories (65-130 ˚C). This constitutes an earlier unobserved source of exposure to acrylamide.The method for extraction of food was studied with regard to yield of acrylamide. It was shown that the yield at pH ≥12 increases 3 - 4 times compared to normal water extraction for some foods products. Extraction at acidic pH or with enzymatic treatment was also tested, showing no effect on yield.In a study with mice the bioaviability of acrylamide extracted with the normal water extration and at alkaline pH was compared. It was shown that the extra acrylamide released at alkaline pH gave insignificant contributions to the in vivo dose, measured by hemoglobin adducts.
10.	Interdisciplinary perspectives on local and regional food in the South Baltic Region 2015 Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)

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