| 1. |
- Spinoglio, L., et al.
(författare)
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- 2017
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Ingår i: Publications Astronomical Society of Australia. - : Cambridge University Press (CUP). - 1323-3580 .- 1448-6083. ; 34
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Tidskriftsartikel (refereegranskat)abstract
- IR spectroscopy in the range 12-230 mu m with the SPace IR telescope for Cosmology and Astrophysics (SPICA) will reveal the physical processes governing the formation and evolution of galaxies and black holes through cosmic time, bridging the gap between the James Webb Space Telescope and the upcoming Extremely Large Telescopes at shorter wavelengths and the Atacama Large Millimeter Array at longer wavelengths. The SPICA, with its 2.5-m telescope actively cooled to below 8 K, will obtain the first spectroscopic determination, in the mid-IR rest-frame, of both the star-formation rate and black hole accretion rate histories of galaxies, reaching lookback times of 12 Gyr, for large statistically significant samples. Densities, temperatures, radiation fields, and gas-phase metallicities will be measured in dust-obscured galaxies and active galactic nuclei, sampling a large range in mass and luminosity, from faint local dwarf galaxies to luminous quasars in the distant Universe. Active galactic nuclei and starburst feedback and feeding mechanisms in distant galaxies will be uncovered through detailed measurements of molecular and atomic line profiles. The SPICA's large-area deep spectrophotometric surveys will provide mid-IR spectra and continuum fluxes for unbiased samples of tens of thousands of galaxies, out to redshifts of z similar to 6.
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| 2. |
- Ottosson, S.
(författare)
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- 1998
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Ingår i: Technovation. - Amsterdam : Elsevier. - 0166-4972 .- 1879-2383. ; 18:4, s. 235-244
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes some of the complex relationships that exist between R&D (research and development) and M&S (marketing and sales). Factors impacting R&D and M&S are analysed such as company size, company age, wishes for changes in the individual company, etc. Seven propositions are presented. One specific finding from the study is that, for different product life cycles (PLCs), R&D and M&S often counteract so that when R&D spendings are allowed to increase, M&S spendings are reduced and vice versa. Management of technology (MoT) is not an exact science, and therefore the paper focuses on magnitudes of order instead of decimals in R&D and M&S expenditures for individual companies depending on branch, and differing situations. One important result of the investigation is that short PLCs means larger R&D spendings, and vice versa. (C) 1998 Elsevier Science Ltd. All rights reserved.
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| 3. |
- Andersson, Hans, 1962-, et al.
(författare)
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- 2007
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Ingår i: 8th International Research Network on Organizing by Projects Conference,2007.
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Konferensbidrag (refereegranskat)abstract
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| 7. |
- Glans, Lotta
(författare)
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Organometallic complexes with antimalarial properties
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Malaria is a serious disease that causes around 800 000 deaths per year. Current malaria control efforts are hampered by the widespread resistance to common antimalarial drugs, such as the 4-aminoquinoline derivative called chloroquine. Previous research has shown that specific modifications of chloroquine, including inclusion of organometallic fragments into the organic framework, can result in compounds that are able to circumvent resistance. In the case of ferroquine, a ferrocene analogue of chloroquine, excellent results against both chloroquine sensitive and chloroquine resistant malaria parasites have been achieved and the drug has completed phase II clinical trials. This thesis describes the synthesis and evaluation of antimalarial activity of metal chloroquine analogues with an integrated “half sandwich” unit (an organometallic moiety with an aromatic π-system and three additional ligands). These complexes can be divided into two groups in which the side chain of the 4-aminoquinoline group is either covalently bound to the aromatic ring of the half sandwich unit or coordinated to the metal in the half sandwich unit. Organometallic complexes based on chromium, manganese, rhenium, ruthenium and osmium are presented. In the case of chromium, manganese and osmium, these are the first reported organometallic complexes with antimalarial activity. The chromium complex [η6-N-(7-chloroquinolin-4-yl)-N′-(2-dimethylamino-methylbenzyl)-ethane-1,2-diamine] tricarbonylchromium showed high antimalarial activity against both a chloroquine sensitive and a chloroquine resistant P. falciparum malaria strain and was more active than the corresponding organic ligand against resistant parasites. The manganese complexes N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cymantrenylbutanamide and N-(7-chloroquinolin-4-yl)-N’-(cymantrenylmethyl)ethane-1,2-diamine, and the rhenium complex N-(2-(7-chloroquinolin-4-ylamino)ethyl)-4-cyrhetrenyl butanamide, all of which lack a terminal tertiary amine, were significantly less active. The ruthenium and osmium complexes [RuCl(η6-p-cymene)(L1)]Cl (L1 = N-(2-((pyridin-2-yl)methylamino)ethyl)-7-chloroquinolin-4-amine) and [MCl(η6-p-cymene)(L2)]Cl (M = Ru, Os; L2 = N-(2-((1-methyl-1H-imidazol-2-yl)methylamino)ethyl)-7-chloroquinolin-4-amine) were less active than their corresponding ligands against both the chloroquine sensitive and the chloroquine resistant parasite strain. In contrast, the complexes [MCl(η6-p-cymene)(L3)] (M = Ru, Os; HL3 = N-(2-((2-hydroxyphenyl)methylimino)ethyl)-7-chloroquinolin-4-amine) were significantly more active than the ligand alone against both parasite strains. Overall, osmium complexes appear to exhibit higher activity than their ruthenium counterparts.
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| 8. |
- Pincikova, Terezia
(författare)
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Vitamin D insufficiency in cystic fibrosis : prevalence, consequences and intervention
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cystic fibrosis (CF) is the most common life-shortening autosomal recessive disease in Caucasians. The major cause of morbidity and mortality is lung disease, characterized by a vicious circle of infection and inflammation. Management of CF requires a multifaceted approach, where intensive chest physiotherapy is combined with aggressive antibiotic treatment, and tight nutritional follow-up. Vitamin D insufficiency has high prevalence among CF patients worldwide. Vitamin D is crucial for maintaining healthy skeleton. Recently, extraskeletal functions of vitamin D have been described. These include immunomodulatory and glucose-lowering properties. Due to lack of relevant studies, vitamin D supplementation in CF is recommended only as one of the means of maintaining bone health. The aim of this thesis was to increase our current understanding of the impact of vitamin D supplementation in CF patients, and provide data needed for designing an efficient vitamin D supplementation policy. First of all, we showed that a majority of Scandinavian CF patients had a suboptimal serum 25-hydroxyvitamin D (s25OHD) level (Paper I), and that the vitamin D doses needed to increase it were high. Cholecalciferol was more efficient at increasing s25OHD than ergocalciferol, and s25OHD monitoring was needed (Paper III). Secondly, we propose that vitamin D induces a broad spectrum of immunomodulatory actions in CF. In the well-defined Scandinavian CF population (n=898), s25OHD was associated negatively with serum total IgG, and positively with lung function (FEV1) in a robust multiple linear regression (MLR) model (Paper I). In line with that, three months long ergocalciferol supplementation in Stockholm CF patients decreased serum total IgG and IgM, whereas cholecalciferol decreased expression of the costimulatory molecule CD40 on dendritic cells. Patients receiving any form of vitamin D decreased T cell activation and IL-8 levels at the end of the supplementation. On the other hand, certain mechanisms of innate immunity were enhanced, such as MCP-1 and sTREM-1. Soluble CD14 increased only in patients reaching 92 < s25OHD < 97 nmol/L, which suggests bell-shaped relationship between s25OHD and soluble CD14. Notably, increase in s25OHD levels was associated with positive changes in lung function and in respiratory quality of life scores (Paper III). Moreover, we demonstrated that s25OHD < 30 nmol/L, s25OHD < 50 nmol/L, and vitamin D insufficiency degree are independent determinants of HbA1c values in Scandinavian CF patients in a MLR model. This indicates that vitamin D may have glucose-lowering properties in CF. In addition, s25OHD < 30 nmol/L and vitamin D insufficiency degree determined the risk of CF-related diabetes (Paper II). In Paper IV we aimed to assess the ability of CF bronchial epithelial (CFBE) cells to convert the inactive 25OHD to the active 1,25(OH)2D, which is an important mechanism ensuring adequate local concentrations of the biologically active 1,25(OH)2D in vivo. Upon addition of 25OHD (100 nmol/L), the amplitude of the increase in 1,25(OH)2D was smaller for the CFBE cells than the non-CF human bronchial epithelial cells (12.0 vs. 33.2 pmol/L). These results indicate that cells harbouring mutations in cftr may have impaired ability to activate vitamin D. In conclusion, this thesis contributes to the understanding of the multifunctional importance of vitamin D in CF. It creates hypotheses about role of vitamin D in chronic inflammation, diabetes and lung function, which need to be studied further.
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| 9. |
- Abreu, P, et al.
(författare)
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Measurement of inclusive rho(0), f(0)(980), f(2)(1270), K-2(*0)(1430) and f '(2)(1525) production in Z(0) decays
- 1999
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 449:3-4, s. 364-382
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- DELPHI results are presented on the inclusive production of the neutral mesons rho(0), f(0)(980), f(2)(1270), K-2(*0)(1430) and f'(2)(1525) in hadronic Z(0) decays. They are based on about 2 million multihadronic events collected in 1994 and 1995, using t
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| 10. |
- Abreu, P, et al.
(författare)
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Search for the lightest chargino at root s=130 and 136 GeV
- 1996
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 382:3, s. 323-336
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A search for pair production of the lightest chargino at root-s = 130.4 and 136.3 GeV has been carried out using the data sample corresponding to the 5.92 pb(-1) recorded by the DELPHI detector during the high energy run of LEP in the last period of 1995.
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