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- Do, Lan, et al.
(author)
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Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : a longitudinal Swedish study
- 2021
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In: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332 .- 1310-0505. ; 60:9, s. 4085-4093
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.METHODS: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.RESULTS: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed.CONCLUSION: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.
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| 3. |
- Fouganthine, Anna, 1970-
(author)
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Dyslexi genom livet : Ett utvecklingsperspektiv på läs- och skrivsvårigheter
- 2012
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Doctoral thesis (other academic/artistic)abstract
- The thesis reports a follow-up study from eight years of age to adulthood for a group of students with dyslexic problems compared to a matched group of students without such problems. The empirical basis of the thesis is provided by the research project, Reading Development in Kronoberg, which has been supplemented by data from adulthood in the form of questionnaires, test results and interviews. The thesis comprises three studies. In Study I, the aim is to examine how reading and writing disabilities emerge during the first school years. The Simple View of Reading, was used to classify the poor readers into various subgroups. In Study II, the reading development of students with reading disability was examined at group and individual levels. The theme of Study III is a comparison of the living conditions of adults in a group of dyslexics compared to a group without difficulties, and to investigate how the participants in the study have tackled their problems. The results reveal a development pattern among dyslexic students, with early phonological problems persisting into adulthood in spite of substantial special education measures, in school Baseline performance at eight years of age is by far the best predictor of adult skills. No clearly discernible subgroups were found among the dyslexic students. The result profiles indicate a great variation among the participants, both regarding function and degree of impairment. Nevertheless, a number of students in the dyslexic groups have achieved surprisingly good word decoding abilities. In addition to the degree of impairment, factors such as reading development, the teaching of reading demands for reading and writing in adult life, and individual coping ability affect the outcome of the perceived difficulties. It is of the utmost importance that special needs education in the future be guided by a thorough assessment and follow-up program where manifest reading and writing skills as well as underlying cognitive functions are profiled. Moreover, intervention should follow evidence-based methods in order to prevent educational failure and social maladjustment among pupils. The thesis demonstrates that reading and writing disabilities have major consequences for educational achievement and working life outcomes, in addition to many other aspects of adult livelihood.
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| 7. |
- Hellman, Urban, et al.
(author)
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Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study.
- 2024
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In: Modern rheumatology. - 1439-7609.
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Journal article (peer-reviewed)abstract
- Objectives There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers, at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker pattern in r-axSpA patients concerning disease phenotypes and disease activity. Methods Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity. Conclusion Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.
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| 8. |
- Hellman, Urban, 1966-, et al.
(author)
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Presence of hyaluronan in lung alveoli in severe Covid-19 : an opening for new treatment options?
- 2020
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In: Journal of Biological Chemistry. - : American Society for Biochemistry and Molecular Biology. - 0021-9258 .- 1083-351X. ; 295:45, s. 15418-15422
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Journal article (peer-reviewed)abstract
- Severe corona virus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined.The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly.Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue.Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs.
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| 9. |
- Hennings, Joakim, et al.
(author)
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[11C]metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings
- 2006
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 91:4, s. 1410-4
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Journal article (peer-reviewed)abstract
- CONTEXT: Adrenal incidentalomas are common findings necessitating extensive laboratory work-up and repetitive radiological examinations. Positron emission tomography (PET) using (11)C-labeled metomidate (MTO) has previously been described as a tool for specific adrenocortical imaging. OBJECTIVE: We evaluated 212 MTO-PET examinations in 173 patients to identify its role in the management of adrenal tumors. DESIGN: Seventy-five histopathological examinations from 73 patients were retrospectively analyzed. SETTING: All examinations were performed at a referral center. PATIENTS: Patients who were operated or biopsied due to adrenal tumors had histopathological diagnoses of adrenocortical adenoma (n = 26), adrenocortical cancer (ACC; n = 13), adrenocortical hyperplasia (n = 8), pheochromocytoma (n = 6), metastasis (n = 3), and tumors of nonadrenal origin (n = 19). MAIN OUTCOME MEASURES: The main outcome measures were statistical analyses and findings while scrutinizing images. The hypothesis that MTO-PET is of value in the management of adrenal tumors, especially incidentaloma, was stated before data collection. RESULTS: Sensitivity was 0.89 and specificity was 0.96 for MTO-PET in proving adrenocortical origin of the lesions. Pheochromocytomas, metastases to the adrenal gland, and nonadrenal masses were all MTO negative. PET measurements using standardized uptake values (SUV) in pathological adrenocortical tissue could differentiate lesions larger than 1-1.5 cm from normal adrenocortical tissue. SUV was higher in aldosterone-hypersecreting adenomas, and the SUV ratio between the tumor and the contralateral gland was significantly higher in all hormonally hypersecreting adenomas as well as in ACC. CONCLUSION: MTO-PET is a specific and sensitive method for diagnosing adrenocortical tumors. MTO-PET is useful in the imaging work-up of adrenal incidentalomas and may be beneficial for the examination of patients with primary aldosteronism or ACC.
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- Karlsson, Robert, et al.
(author)
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Restvärde hos vägar : en kunskaps- och idesammanställning kring hur investeringar ska styras för lägre LCC
- 2011
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Reports (other academic/artistic)abstract
- I rapporten utreds hur begreppet restvärde kan användas vid investeringar i vägar ochväghållning för att analysera tekniska lösningar eller utforma krav för upphandling.Syftet är att utarbeta ett ramverk med principer som knyter samman ekonomiska övervägandenoch teknisk dimensionering, som i sin tur kan bidra till mer optimala investeringari vägar ur ett långsiktigt perspektiv. Rapporten är avgränsad till investeringar ivägkroppen, men paralleller dras till andra områden.Inledningsvis granskas begreppet och vilka behov som föreligger. Restvärde kan sägasspegla framtida nytta med en väganläggning minus kostnader för förvaltning. För deflesta tillämpningar kan nyttan antas lika medan väghållarkostnaderna påverkas av olikatekniska lösningar. Därmed reduceras problemet till att främst fokusera på kostnader förframtida drift och underhåll. I rapporten redogörs för hur nedbrytning kan prognosticerasoch åtgärdsbehov förutsägas. Denna information ligger sedan till grund för ettramverk för bedömning av framtida kostnader för drift och underhåll av vägar. Slutligenutarbetas förslag på hur denna kostnadsuppskattning och tillhörande restvärdesbedömningkan tillämpas inom upphandling på funktion, ersättningsmodeller samt meroptimerad väghållning ur LCC-synvinkel.
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