| 1. |
- Brodin, N., et al.
(författare)
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Coaching patients with early rheumatoid arthritis to healthy physical activity : A multicenter, randomized, controlled study
- 2008
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Ingår i: Arthritis and Rheumatism. - Hoboken, NJ : Wiley. - 0004-3591 .- 1529-0131. ; 59:3, s. 325-331
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To investigate the effect of a 1-year coaching program for healthy physical activity on perceived health status, body function, and activity limitation in patients with early rheumatoid arthritis. Methods. A total of 228 patients (169 women, 59 men, mean age 55 years, mean time since diagnosis 21 months) were randomized to 2 groups after assessments with the EuroQol visual analog scale (VAS), Grippit, Timed-Stands Test, Escola Paulista de Medicina Range of Motion scale, walking in a figure-of-8, a visual analog scale for pain, the Health Assessment Questionnaire disability index, a self-reported physical activity questionnaire, and the Disease Activity Score in 28 joints. All patients were regularly seen by rheumatologists and underwent rehabilitation as prescribed. Those in the intervention group were further individually coached by a physical therapist to reach or maintain healthy physical activity (=30 minutes, moderately intensive activity, most days of the week). Results. The retention rates after 1 year were 82% in the intervention group and 85% in the control group. The percentages of individuals in the intervention and control groups fulfilling the requirements for healthy physical activity were similar before (47% versus 51%, P > 0.05) and after (54% versus 44%, P > 0.05) the intervention. Analyses of outcome variables indicated improvements in the intervention group over the control group in the EuroQol VAS (P = 0.025) and muscle strength (Timed-Stands Test, P = 0.000) (Grippit, P = 0.003), but not in any other variables assessed. Conclusion. A 1-year coaching program for healthy physical activity resulted in improved perceived health status and muscle strength, but the mechanisms remain unclear, as self-reported physical activity at healthy level did not change. © 2008, American College of Rheumatology.
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| 2. |
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| 3. |
- Ekborg, Margareta, et al.
(författare)
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SCIENCE FOR LIFE – a conceptual framework for construction and analysis of socio-scientific cases
- 2009
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Ingår i: NorDiNa. - Oslo : Naturfagsenteret. - 1504-4556 .- 1894-1257. ; 5:1, s. 35-46
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to describe a conceptual framework to be used as a tool for analyzing work with socio-scientific issues (SSI) and for constructing SSI cases in secondary school. The framework consists of six components describing the more detailed characteristics of SSI. The components were chosen to reflect what we know from research about what might have an impact on students’ learning and interest in science. Six socio-scientific cases were then constructed and these are discussed in the article. The cases are relevant in that they both display the characteristics of SSI and meet the requirements of the Swedish national curriculum. The components and the cases are described in a table. This work is the first step in an evidence-based research project aiming at investigating if, how and why students and teachers in secondary school develop knowledge and interests when working with SSI.
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| 4. |
- Högström, Per, 1972-, et al.
(författare)
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Lab Work and Learning in Secondary School Chemistry : The Importance of Teacher and Student Interaction
- 2009
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Ingår i: Research in science education. - Dordrecht : Springer Netherlands. - 0157-244X .- 1573-1898. ; 40:4, s. 505-523
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Tidskriftsartikel (refereegranskat)abstract
- Laboratory work is considered essential in promoting students’ learning of science and of scientific inquiry. What the students perceive as important to learn from a regular laboratory exercise is probably affected by the teacher’s objectives. We study the extent to which one teacher’s objectives are fulfilled during lab work, and how teacher-student and student-student interactions contribute to developing learning experiences from the laboratory exercise. Do students encounter opportunities to learn in agreement with the teacher’s objectives? This explanatory single case study includes use of a palette of methods, such as pre- and post-interviews, observations and video documentation from an experienced secondary school teacher and her 8th grade (aged 13-14) students’ laboratory work. Our results point to the importance of teacher involvement to help students understand what to look for, how to do it and why. Especially teacher-student interactions during lab work seemed to influence what students perceived as important to learn. In the laboratory exercise in this case, the teacher helped the students to observe and to use their observations in their explanations. The lab work included learning experiences other than those addressed by the teacher, and the teacher’s intentions were partially fulfilled. Not only what the teacher says, but also how the teacher acts is important to help students understand what to learn from a laboratory exercise. © 2009 Springer Science+Business Media B.V.
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| 5. |
- Lind, Martin, 1980-, et al.
(författare)
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Costs and limits of phenotypic plasticity in island populations of the common frog Rana temporaria under divergent selection pressures
- 2009
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Ingår i: Evolution. - : John Wiley & Sons, Inc.. - 0014-3820 .- 1558-5646. ; 63:6, s. 1508-1518
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Tidskriftsartikel (refereegranskat)abstract
- Costs and limits are assumed to be the major constraints on the evolution of phenotypic plasticity. However, despite their expected importance, they have been surprisingly hard to find in natural populations. It has therefore been argued that natural selection might have removed high-cost genotypes in all populations. However, if costs of plasticity are linked to the degree of plasticity expressed, then high costs of plasticity would only be present in populations where increased plasticity is under selection. We tested this hypothesis by investigating costs and limits of adaptive phenotypic plasticity in development time in a common garden study of island populations of the common frog Rana temporaria, which have varying levels of development time and phenotypic plasticity. Costs of plasticity were only found in populations with high-plastic genotypes, whereas the populations with the most canalized genotypes instead had a cost of canalization. Moreover, individuals displaying the most extreme phenotypes also were the most plastic ones, which mean we found no limits of plasticity. This suggests that costs of plasticity increase with increased level of plasticity in the populations, and therefore costs of plasticity might be more commonly found in high-plastic populations.
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| 6. |
- Lind, Martin, 1980-, et al.
(författare)
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Pool desiccation and developmental thresholds in the common frog, Rana temporaria.
- 2008
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Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 275, s. 1073-1080
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Tidskriftsartikel (refereegranskat)abstract
- The developmental threshold is the minimum size or condition that a developing organism must have reached in order for a life-history transition to occur. Although developmental thresholds have been observed for many organisms, inter-population variation among natural populations has not been examined. Since isolated populations can be subjected to strong divergent selection, population divergence in developmental thresholds can be predicted if environmental conditions favour fast or slow developmental time in different populations. Amphibian metamorphosis is a well-studied life-history transition, and using a common garden approach we compared the development time and the developmental threshold of metamorphosis in four island populations of the common frog Rana temporaria: two populations originating from islands with only temporary breeding pools and two from islands with permanent pools. As predicted, tadpoles from time-constrained temporary pools had a genetically shorter development time than those from permanent pools. Furthermore, the variation in development time among females from temporary pools was low, consistent with the action of selection on rapid development in this environment. However, there were no clear differences in the developmental thresholds between the populations, indicating that the main response to life in a temporary pool is to shorten the development time.
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| 7. |
- Lind, Martin, 1980-, et al.
(författare)
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The degree of adaptive phenotypic plasticity is correlated with the spatial environmental heterogeneity experienced by island populations of Rana temporaria.
- 2007
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Ingår i: Journal of Evolutionary Biology. - : Wiley. - 1010-061X .- 1420-9101. ; 20:4, s. 1288-1297
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Tidskriftsartikel (refereegranskat)abstract
- Although theoretical models have identified environmental heterogeneity as a prerequisite for the evolution of adaptive plasticity, this relationship has not yet been demonstrated experimentally. Because of pool desiccation risk, adaptation of development rate is important for many amphibians. In a simulated pool-drying experiment, we compared the development time and phenotypic plasticity in development time of populations of the common frog Rana temporaria, originating from 14 neighbouring islands off the coast of northern Sweden. Drying regime of pools used by frogs for breeding differed within and among the islands. We found that the degree of phenotypic plasticity in development time was positively correlated with the spatial variation in the pool-drying regimes present on each island. In addition, local adaptation in development time to the mean drying rate of the pools on each island was found. Hence, our study demonstrates the connection between environmental heterogeneity and developmental plasticity at the island population level, and also highlights the importance of the interplay between local specialization and phenotypic plasticity depending on the local selection pressures.
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| 8. |
- Olofsson, Anna, et al.
(författare)
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General beliefs and environmental concern : Transatlantic comparisons
- 2006
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Ingår i: Environment and Behavior. - Thousand Oaks, CA : SAGE Publications. - 0013-9165 .- 1552-390X. ; 38:6, s. 768-790
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the study was to empirically test whether grouping people according to their general beliefs, combined with positional factors, can explain environmental concern, and whether there are country differences in this respect. The study is based on the United States, Canadian, Norwegian, and Swedish parts of The International Social Survey Program (ISSP) survey 2000 on environmental concern. The four countries were paired resulting in a comparison between North America and Scandinavia. The results showed that general beliefs, together with education and political affiliation, were the most stable predictors of environmental concern, and that adding general beliefs to the analysis improves the explanatory power in a significant way.
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| 9. |
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| 10. |
- Dzhambazov, Balik, et al.
(författare)
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Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules
- 2006
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Ingår i: Journal of Immunology. - Rockville, MD : American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 176, s. 1525-33
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Tidskriftsartikel (refereegranskat)abstract
- In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no such effect. CIA dependent on other MHC class II molecules (Ar/Er) was also down-regulated, indicating a bystander vaccination effect. T cells could transfer the amelioration of CIA, showing that the protection is an active process. Thus, a complex between MHC class II molecules and a posttranslationally modified peptide offers a new possibility for treatment of chronically active autoimmune inflammation such as rheumatoid arthritis. © 2006 by The American Association of Immunologists, Inc.
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