| 51. |
- Neasham, David, et al.
(författare)
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Occupation and risk of lymphoma : a multicentre prospective cohort study (EPIC)
- 2011
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 68:1, s. 77-81
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Tidskriftsartikel (refereegranskat)abstract
- The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.
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| 52. |
- Noethlings, Ute, et al.
(författare)
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Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population
- 2008
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Ingår i: Journal of Nutrition. - 1541-6100. ; 138:4, s. 775-781
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Tidskriftsartikel (refereegranskat)abstract
- We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at baseline between 1992 and 2000 using validated country-specific questionnaires. A total of 1346 deaths occurred. Multivariate relative risks (RR) for all-cause mortality were estimated in Cox regression models and FIR for cause-specific mortality were derived in a competing risk model. An increment in intake of total vegetables, legumes, and fruit of 80 g/d was associated with a RR of death from all causes of 0.94 [95% CI 0.90-0.98]. Analyzed separately, vegetables and legumes were associated with a significantly reduced risk, whereas nonsignificant inverse associations for fruit intake were observed. Cardiovascular disease (CVD) mortality and mortality due to non-CVD/non-cancer causes were significantly inversely associated with intake of total vegetables, legumes, and fruit (RR 0.88 [95% CI 0.81-0.95] and 0.90 [0.82-0.99], respectively) but not cancer mortality 0.08 [0.99-1.17]). Intake of vegetables, legumes, and fruit was associated with reduced risks of all-cause and CVD mortality in a diabetic population. The findings support the current state of evidence from general population studies that the protective potential of vegetable and fruit intake is larger for CVD than for cancer and suggest that diabetes patients may benefit from a diet high in vegetables and fruits.
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| 53. |
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| 54. |
- Obón-Santacana, Mireia, et al.
(författare)
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Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
- 2017
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6207 .- 1436-6215. ; 56:3, s. 1157-1168
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively.RESULTS: The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively.CONCLUSIONS: Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.
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| 55. |
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| 56. |
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| 57. |
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| 58. |
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| 59. |
- Perez-Cornago, Aurora, et al.
(författare)
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Comparison of 2 different approaches to calculate dietary intakes in the Oxford WebQ questionnaire used in UK Biobank
- 2021
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Konferensbidrag (refereegranskat)abstract
- Introduction: The Oxford WebQ is a web-based 24-hour dietary assessment tool used in UK Biobank and other large-scale prospective studies to assess dietary intake. The food composition table (FCT) used to calculate nutrient intakes, the McCance and Widdowson’s FCT 6th edition (2002), has recently been replaced with the UK Nutrient Databank (2013), as this FCT is, on average, closer in time to when participants completed the questionnaire. Moreover, portion sizes, personalisation of fats used in cooking, food group disaggregation and the underlying code for nutrient calculation were revised and updated. In this study we aim to compare the two versions of obtained nutrient intakes in UK Biobank participants. Methods: A subsample of UK Biobank participants recruited towards the end of the recruitment period and/or those who provided email addresses, completed the Oxford WebQ questionnaire up to 5 times (2009/2012). After excluding participants with extreme energy intakes (men: >20,000 kJ/d, women: 18,000 kJ/d), a total of 210,109 participants, who completed the Oxford WebQ questionnaire at least once, were included. Means and standard deviations of macronutrient and fibre intakes were averaged for all completed WebQ questionnaires for each participant and Spearman correlations and paired t-tests were used to compare the mean nutrient intakes between the two versions.Results: All nutrient intake differences were significantly different from zero after the WebQ update (P<0.001). Compared to the previous version , mean nutrient intakes in this updated version were slightly lower for energy (-144 kJ/d), protein (-1.2 g/d), total fat (-4.5 g/d) and saturated fat (-2.7 g/d), but slightly higher for carbohydrates (+1.8 g/d), total sugars (+5.3 g/d) and fibre (+1.4 g/d). High correlations were found between nutrients calculated using the two versions: energy (r=0.96), protein (r=0.97), total fat (r=0.95), carbohydrates (r=0.95), saturated fat (r=0.91), total sugars (r=0.96), and fibre (r=0.94).Discussion: Absolute differences in nutrient intakes between the two versions were observed, although the ranking of individuals was minimally affected. Future work will assess the heterogeneous differences among individuals caused by the changes made to the WebQ, and this updated version will be available to all studies using the Oxford-WebQ.
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| 60. |
- Piernas, Carmen, et al.
(författare)
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Describing a new food group classification system for UK biobank : analysis of food groups and sources of macro- and micronutrients in 208,200 participants
- 2021
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Ingår i: European Journal of Nutrition. - : Springer. - 1436-6207 .- 1436-6215. ; 60:5, s. 2879-2890
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The UK Biobank study collected detailed dietary data using a web-based self-administered 24 h assessment tool, the Oxford WebQ. We aimed to describe a comprehensive food grouping system for this questionnaire and to report dietary intakes and key sources of selected nutrients by sex and education.METHODS: Participants with at least one valid 24-h questionnaire were included (n = 208,200). Dietary data were grouped based on the presence of nutrients as well as culinary use, processing, and plant/animal origin. For each food group, we calculated the contribution to energy intake, key macronutrients, and micronutrients. We also identified the top contributors to energy intake, free sugars and saturated fat by sex and education.RESULTS: From the 93 food groups, the top five contributors to energy intake (in descending order) were: desserts/cakes/pastries; white bread; white pasta/rice; bananas/other fruit; semi-skimmed milk. Wine, beer, and fruit juices were the top beverage contributors to overall energy intake. Biscuits, and desserts/cakes/pastries were the highest contributors to free sugars, total fat, and saturated fat intakes, but also contributed to the calcium and iron intakes. Top contributors to energy, saturated fat, and free sugars were broadly similar by sex and education category, with small differences in average nutrient intakes across the population.CONCLUSION: This new food classification system will support the growing interest in the associations between food groups and health outcomes and the development of food-based dietary guidelines. Food group variables will be available to all users of the UK Biobank WebQ questionnaire.
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