| 65761. |
- McCormick, Kes, et al.
(författare)
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Advancing Sustainable Urban Transformation
- 2013
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 50, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Despite increased awareness of the urgency to respond to climate change and to promote sustainable development, there are few powerful initiatives that are decisively shifting urban development in a sustainable, resilient and low-carbon direction. This Special Volume of the Journal of Cleaner Production explores sustainable urban transformation focusing on structural transformation processes – multi-dimensional and radical change – that can effectively direct urban development towards ambitious sustainability goals. The 20 articles are based on 35 cases and over 130 surveyed examples of urban initiatives on sustainability in many countries. While cities in Europe dominate, there are also examples from North America, South America, Africa, Asia and Oceania. The combined articles in this Special Volume contribute to knowledge and understanding on sustainable urban transformation across a range of areas, including governance and planning, innovation and competitiveness, lifestyle and consumption, resource management and climate mitigation and adaptation, transport and accessibility, buildings, and the spatial environment and public space. Overall, this Special Volume documents and analyses real-life action in cities and communities around the world to respond to sustainability challenges and it provides critical insights into how to catalyse, intensify and accelerate sustainable urban transformation globally. A main finding of the articles is that governance and planning are the key leverage points for transformative change.
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| 65762. |
- McCormick, Kes, et al.
(författare)
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Sustainable urban transformation and the green urban economy
- 2013
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Ingår i: The economy of green cities. - Bonn, Tyskland : International Council for Local Environmental InitiativesInternational Council for Local Environmental Initiatives. - 9789400719699 ; , s. 33-43
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Bokkapitel (refereegranskat)
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| 65763. |
- McCoy, Christopher Cameron, et al.
(författare)
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Back to the Future: Whole Blood Resuscitation of the Severely Injured Trauma Patient
- 2021
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Ingår i: Shock. - : LIPPINCOTT WILLIAMS & WILKINS. - 1073-2322 .- 1540-0514. ; 56:1S
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Tidskriftsartikel (refereegranskat)abstract
- Following advances in blood typing and storage, whole blood transfusion became available for the treatment of casualties during World War I. While substantially utilized during World War II and the Korean War, whole blood transfusion declined during the Vietnam War as civilian centers transitioned to blood component therapies. Little evidence supported this shift, and recent conflicts in Iraq and Afghanistan have renewed interest in military and civilian applications of whole blood transfusion. Within the past two decades, civilian trauma centers have begun to study transfusion protocols based upon cold-stored, low anti-A/B titer type O whole blood for the treatment of severely injured civilian trauma patients. Early data suggests equivalent or improved resuscitation and hemostatic markers with whole blood transfusion when compared to balanced blood component therapy. Additional studies are taking place to define the optimal way to utilize low-titer type O whole blood in both prehospital and trauma center resuscitation of bleeding patients.
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| 65764. |
- McCreaddie, May, et al.
(författare)
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Reconciling the good patient persona with problematic and non-problematic humour: A grounded theory
- 2009
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Ingår i: International Journal of Nursing Studies. - : Elsevier BV. - 0020-7489 .- 1873-491X. ; 46:8, s. 1079-1091
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundHumour is a complex phenomenon, incorporating cognitive, emotional, behavioural, physiological and social aspects. Research to date has concentrated on reviewing (rehearsed) humour and ‘healthy’ individuals via correlation studies using personality-trait based measurements, principally on psychology students in laboratory conditions. Nurses are key participants in modern healthcare interactions however, little is known about their (spontaneous) humour use.AimsA middle-range theory that accounted for humour use in CNS-patient interactions was the aim of the study. The study reviewed the antecedents of humour exploring the use of humour in relation to (motivational) humour theories.Participants and settingTwenty Clinical Nurse Specialist–patient interactions and their respective peer groups in a country of the United Kingdom.MethodAn evolved constructivist grounded theory approach investigated a complex and dynamic phenomenon in situated contexts. Naturally occurring interactions provided the basis of the data corpus with follow-up interviews, focus groups, observation and field notes. A constant comparative approach to data collection and analysis was applied until theoretical sufficiency incorporating an innovative interpretative and illustrative framework. This paper reports the grounded theory and is principally based upon 20 CNS–patient interactions and follow-up data. The negative case analysis and peer group interactions will be reported in separate publications.FindingsThe theory purports that patients’ use humour to reconcile a good patient persona. The core category of the good patient persona, two of its constituent elements (compliance, sycophancy), conditions under which it emerges and how this relates to the use of humour are outlined and discussed. In seeking to establish and maintain a meaningful and therapeutic interaction with the CNS, patients enact a good patient persona to varying degrees depending upon the situated context. The good patient persona needs to be maintained within the interaction and is therefore reconciled with potentially problematic or non-problematic humour use. Humour is therefore used to deferentially package concerns (potentially problematic humour) or affiliate (potentially non-problematic humour). This paper reviews the good patient persona (compliance, sycophancy), potentially problematic humour (self-disparaging, gallows) and briefly, non-problematic humour (incongruity).ConclusionsThe middle-range theory differentiates potentially problematic humour from non-problematic humour and notes that how humour is identified and addressed is central to whether patients concerns are resolved or not. The study provides a robust review of humour in healthcare interactions with important implications for practice. Further, this study develops and extends humour research and contributes to an evolved application of constructivist grounded theory.
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| 65765. |
- McCreaddie, May, et al.
(författare)
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The purpose and function of humour in health, health care and nursing : a narrative review
- 2008
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Ingår i: Journal of Advanced Nursing. - : John Wiley & Sons. - 0309-2402 .- 1365-2648. ; 61:6, s. 585-595
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Tidskriftsartikel (refereegranskat)abstract
- Aim. This paper is a report of a review conducted to identify, critically analyse and synthesize the humour literature across a number of fields related to health, health care and nursing.Background. The humour–health hypothesis suggests that there is a positive link between humour and health. Humour has been a focus of much contention and deliberation for centuries, with three theories dominating the field: the superiority or tendentious theory, the incongruity theory and the relief theory.Data sources. A comprehensive literature search was carried out in January 2007 using a number of databases, keywords, manual recursive searching and journal alerts (January 1980–2007) cross‐referenced with the bibliographic databases of the International Society of Humor Studies. An inclusion and exclusion criterion was identified.Review methods. A narrative review of evidence‐ and non‐evidence‐based papers was conducted, using a relevant methodological framework with additional scrutiny of secondary data sources in the latter. Humour theories, incorporating definition, process and impact constituted a significant part of the appraisal process.Results. A total of 1630 papers were identified, with 220 fully sourced and 88 included in the final review. There is a dearth of humour research within nursing yet, ironically, an abundance of non‐evidence‐based opinion citing prerequisites and exclusion zones. Examination of physician–patient interaction and the humour–health hypothesis demonstrates that use of humour by patients is both challenging and revealing, particularly with regard to self‐deprecating humour.Conclusion. Nurses and nursing should adopt a circumspect and evidenced‐based approach to humour use in their work.
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| 65766. |
- McCulloch, Laura J, et al.
(författare)
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COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity.
- 2015
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Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 156:1, s. 134-46
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Tidskriftsartikel (refereegranskat)abstract
- Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability and contributes to metabolic dysfunction. Collagen type VI, alpha3 (COL6A3) encodes one subunit of a fibrotic extracellular matrix (ECM) protein highly expressed in rodent AT. Knock-out of collagen VI in rodent AT led to a significant improvement in metabolic health in obese, diabetic (ob/ob) mice however, it is unknown whether this collagen has the same metabolic significance in human AT. We therefore aimed to undertake a comprehensive assessment of COL6A3 in relation to human AT and obesity. Characterisation of COL6A3 in human AT showed 5 fold higher expression in the stromalvascular fraction compared with adipocyte expression and significantly higher expression in subcutaneous than omental AT. In both depots COL6A3 expression appeared to be lowered in obesity, whilst diet and surgery-induced weight loss increased COL6A3 expression in subcutaneous AT. Leptin treatment caused a dose dependent decrease in COL6A3 expression although no effect was seen with insulin or glucose treatment and no difference observed in subjects with diabetes. In addition, we found that the collagen expression profile in humans differs significantly from rodents as COL6A3 does not appear to be the predominant collagen in adipose, muscle or liver. Our findings oppose those initially seen in rodent studies and most importantly, demonstrate a direct regulation of COL6A3 by leptin. This highlights the importance of a paracrine leptin signalling pathway in human AT and suggests an additional mechanism by which leptin can regulate ECM composition and with it AT expandability.
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| 65767. |
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| 65768. |
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| 65769. |
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| 65770. |
- McDonagh, Theresa A, et al.
(författare)
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European Society of Cardiology Heart Failure Association Standards for delivering heart failure care
- 2011
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Ingår i: EUROPEAN JOURNAL OF HEART FAILURE. - : Oxford University Press. - 1388-9842. ; 13:3, s. 235-241
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Tidskriftsartikel (refereegranskat)abstract
- The management of heart failure (HF) is complex. As a consequence, most cardiology society guidelines now state that HF care should be delivered in a multiprofessional manner. The evidence base for this approach now means that the establishment of HF management programmes is a priority. This document aims to summarize the key elements which should be involved in, as well as some more desirable features which can improve the delivery of care in a HF management programme, while bearing in mind that the specifics of the service may vary from site to site. We envisage a situation whereby all patients have access to the best possible care, including improved access to palliative care services, informed by and responsive to advances in diagnosis management and treatment. The goal should be to provide a seamless system of care across primary and hospital care so that the management of every patient is optimal, no matter where they begin or continue their health-care journey.
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