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Search: db:Swepub > (2005-2009) > Karolinska Institutet

  • Result 1-10 of 29154
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  • Aaltonen, Kirsimari, et al. (author)
  • Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer
  • 2009
  • In: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 113:1, s. 75-82
  • Journal article (peer-reviewed)abstract
    • Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P < 0.0005), high cyclin A (P < 0.0005) and Ki67 (P < 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P < 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P < 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers.
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  • Aaltonen, Kirsimari, et al. (author)
  • High cyclin B1 expression is associated with poor survival in breast cancer
  • 2009
  • In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 100:7, s. 1055-60
  • Journal article (peer-reviewed)abstract
    • Cyclin B1 regulates the G(2)-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological variables and prognostic role in breast cancer are not fully understood. Traditionally used prognostic criteria identify large subset of patients to receive adjuvant chemotherapy and to be exposed to adverse effects. A reliable and simple method helping prognostic evaluation in breast cancer is needed. We analysed cyclin B1 expression on 1348 invasive breast cancers and studied correlations with other histopathological variables and survival. High cyclin B1 correlated with high tumour grade, large tumour size and positive nodal status, oestrogen and progesterone receptor negativity, positive HER2 and p53 status, young age at diagnosis, and high cyclin E, cyclin A and Ki67 expression. Among patients not given adjuvant chemotherapy high cyclin B1 was a strong predictor of shorter overall and metastasis-free survival (RR 3.74, P<0.0005 and RR 3.51, P<0.0005, respectively), and remained as an independent prognostic factor also in multivariate analysis (RR 1.80, P=0.04 and RR 2.31, P=0.02, respectively). This study suggests high cyclin B1 associates with aggressive phenotype and is an independent prognostic factor in breast cancer.
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  • Aaro, LE, et al. (author)
  • Promoting sexual and reproductive health in early adolescence in South Africa and Tanzania: development of a theory- and evidence-based intervention programme
  • 2006
  • In: Scandinavian journal of public health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 34:2, s. 150-158
  • Journal article (peer-reviewed)abstract
    • Aims: Action to prevent the spread of HIV among young people in Sub-Saharan Africa is needed urgently. In order to be effective, such action should be theory and evidence based and carefully adapted to local cultures and contexts. The present article describes the organization, theoretical basis, and methodological approach of a project that aims at developing and evaluating school-based interventions targeting adolescents aged 12—14 years. Methods: Researchers from European and African universities have developed interventions that were conducted in three sites: Cape Town and Polokwane (South Africa) and Dar es Salaam (Tanzania). In each site the interventions were evaluated through large-scale field experiments with intervention schools and delayed intervention schools and with baseline and two follow-up data collections. Mimimum sample sizes were estimated for each site based on local data and taking into acount that the unit of allocation was schools and not individual students (the design effect). During the formative phase as well as within the field experiments, qualitative studies were also conducted. Discussion: The interventions were developed consistent with the Intervention Mapping approach, and the theoretical framework was based on a modified version of the Theory of Planned Behaviour. The limitations of Western social cognition models were recognized, and the theoretical framework has therefore been expanded in two directions: towards integrating cultural processes and towards taking societal factors and constraints into account. Conclusion: The project will throw light on the application of social cognition models as well as the usefulness of the Intervention Mapping approach to intervention development in sub-Saharan Africa.
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  • Result 1-10 of 29154
Type of publication
journal article (22086)
conference paper (4874)
doctoral thesis (1840)
research review (221)
licentiate thesis (121)
book chapter (7)
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other publication (4)
review (1)
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Type of content
peer-reviewed (20525)
other academic/artistic (8616)
pop. science, debate, etc. (13)
Author/Editor
Hemminki, K (236)
KLARESKOG, L (207)
aut (192)
Lindholm, B (190)
Winblad, B (188)
Halldin, C (183)
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Ringden, O (173)
Stenvinkel, P (168)
Gustafsson, JA (156)
Fuxe, K (127)
Axelsson, J (108)
Glimelius, Bengt (105)
Bulik, CM (103)
Kere, J (103)
Farde, L (102)
Wolk, Alicja (101)
Hamsten, A (101)
Jonsson, B (100)
Ekbom, A (97)
Dillner, Joakim (97)
Remberger, M. (96)
Cnattingius, S (95)
Heimburger, O (95)
Gulyas, B (93)
Hillert, J (92)
Bergh, J (90)
Hall, P (90)
Ljungman, P (90)
Pedersen, NL (89)
Hokfelt, T (87)
Granath, F. (85)
Arner, P (84)
Aarsland, D (83)
Ingelman-Sundberg, M (83)
Bjorkholm, M (81)
Weiderpass, E (80)
Lundberg, IE (80)
Rasmussen, F (80)
Barany, P (80)
Qureshi, AR (79)
Ogren, SO (78)
Adami, HO (78)
Brismar, K (76)
Lichtenstein, P. (76)
de Faire, U (76)
Montgomery, Scott M. (76)
Alfredsson, L (75)
Makitie, O (75)
Landgren, O (75)
Ruiz, JR (75)
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University
Karolinska Institutet  (29154)Undo refine
Uppsala University (2482)
Lund University (1266)
University of Gothenburg (927)
Umeå University (871)
Linköping University (866)
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Stockholm University (642)
Örebro University (611)
Royal Institute of Technology (456)
Mälardalen University (203)
Södertörn University (177)
Mid Sweden University (133)
Högskolan Dalarna (116)
Marie Cederschiöld högskola (104)
The Swedish School of Sport and Health Sciences (92)
Jönköping University (89)
Red Cross University College (81)
Linnaeus University (78)
Sophiahemmet University College (68)
University of Gävle (62)
University of Borås (58)
Chalmers University of Technology (53)
Karlstad University (42)
Luleå University of Technology (40)
University of Skövde (38)
Halmstad University (36)
Swedish University of Agricultural Sciences (32)
Stockholm School of Economics (25)
Malmö University (22)
RISE (15)
Kristianstad University College (12)
Blekinge Institute of Technology (8)
University West (5)
Swedish National Defence College (2)
VTI - The Swedish National Road and Transport Research Institute (2)
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Language
English (29099)
Swedish (49)
Undefined language (6)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3473)
Natural sciences (538)
Social Sciences (405)
Engineering and Technology (100)
Agricultural Sciences (23)
Humanities (17)

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