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Sökning: swepub > (2007)

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55561.
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55565.
  • Wallin, Åsa, et al. (författare)
  • Alzheimer's disease - Safety and dropout in long-term galantamine treatment in a routine clinical setting
  • 2007
  • Ingår i: New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2007. ; , s. 245-249
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • 276 patients with Alzheimer's disease receiving galantamine in the Swedish Alzheimer Treatment Study were investigated for safety and dropout. Completion rates and reasons for dropout were monitored. The occurrence and time of death was investigated. Galantamine was well tolerated and few side effects were observed. The most frequent cause of dropout during the first year was side effects (n=9), the second and third year, because of adding memantine, which was overall the most frequent cause for dropout (28%). The observed death rate in the study population was not higher than in the average Swedish population (matched for age and gender). Completion-rates were high (51%) compared to previous 3-year studies of cholinesterase inhibitor treated patients.
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55567.
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55568.
  • Wallström, Peter, et al. (författare)
  • A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden).
  • 2007
  • Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 18:10, s. 1107-1121
  • Tidskriftsartikel (refereegranskat)abstract
    • To study the associations between intake of various types of fat and risk of prostate cancer (PCa) in a population-based cohort. We have studied 10,564 initially cancer-free men of the Malmo Diet and Cancer cohort, aged 45-73 years. Diet was assessed by a modified diet history method. Cases and clinical characteristics were ascertained via national and regional registry data. During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Out of these, 281 were classified as advanced. There were 202 cases occurring before 65 years of age. After adjustment for age and energy intake, there was no association between intake of any types of fat and risk of PCa, or between fat intake and advanced PCa or PCa occurring in persons aged < 65 years. However, we observed positive associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and risk of PCa. After adjustment for multiple confounders, the latter associations were weakened, but the results were otherwise virtually unchanged. This large study, with high-validity dietary data, does not support an association between intake of total, saturated, or mono-unsaturated fat and PCa risk. The observed associations between EPA/DHA intakes and PCa are difficult to interpret.
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55569.
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55570.
  • Walther, G.R., et al. (författare)
  • Palms tracking climate change
  • 2007
  • Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-8238 .- 1466-822X. ; 16, s. 801-809
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim Many species are currently expanding their ranges in response to climate change, but the mechanisms underlying these range expansions are in many cases poorly understood. In this paper we explore potential climatic factors governing the recent establishment of new palm populations far to the north of any other viable palm population in the world. Location Southern Switzerland, Europe, Asia and the world. Methods We identified ecological threshold values for the target species, Trachycarpus fortunei, based on gridded climate data, altitude and distributional records from the native range and applied them to the introduced range using local field monitoring and measured meteorological data as well as a bioclimatic model. Results We identified a strong relationship between minimum winter temperatures, influenced by growing season length and the distribution of the palm in its native range. Recent climate change strongly coincides with the palm's recent spread into southern Switzerland, which is in concert with the expansion of the global range of palms across various continents. Main conclusions Our results strongly suggest that the expansion of palms into (semi-)natural forests is driven by changes in winter temperature and growing season length and not by delayed population expansion. This implies that this rapid expansion is likely to continue in the future under a warming climate. Palms in general, and T. fortunei in particular, are significant bioindicators across continents for present-day climate change and reflect a global signal towards warmer conditions.
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