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  • Resultat 1-10 av 6731
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  • Lindmark, Eva, et al. (författare)
  • IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood
  • 1998
  • Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 102:2, s. 597-604
  • Tidskriftsartikel (refereegranskat)abstract
    • Interleukin 4 (IL-4), IL-10 and IL-13 are all known to modulate several proinflammatory functions in human monocytes. They have also previously been shown to down-regulate lipopolysaccharide (LPS)-induced tissue factor (TF) expression in isolated cultured monocytes. In this study we investigated the effect of these three cytokines on the induction of monocytic TF in a whole blood environment at three levels: mRNA quantitation, surface antigen expression and procoagulant activity. We showed that IL-10 attenuated LPS-induced monocyte TF expression and activity in whole blood in a concentration-dependent manner, both when added to the blood prior to LPS and, although to a lesser extent, when added up to 1 h subsequent to LPS challenge. Maximum inhibition occurred at 5 ng/ml of IL-10 when the cytokine was added before LPS. IL-4 and IL-13, however, did not exhibit any inhibitory effect in the whole blood environment, contrary to the reported findings in cell culture experiments. Our results confirm the potential of IL-10 as an anti-inflammatory, TF-preventing drug, whereas the effects of IL-4 and IL-13 on monocytes in whole blood seem more complex, and require further investigation.
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  • Roverso, Roberto, 1982- (författare)
  • Design and Implementation of Centrally-Coordinated Peer-to-Peer Live-streaming
  • 2011
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In this thesis, we explore the use of a centrally-coordinated peer-to-peer overlay as a possible solution to the live streaming problem. Our contribution lies in showing that such approach is indeed feasible given that a number of key challenges are met. The motivation behind exploring an alternative design is that, although a number of approaches have been investigated in the past, e.g. mesh-pull and tree-push, hybrids and best-of-both-worlds mesh-push, no consensus has been reached on the best solution for the problem of peer-to-peer live streaming, despite current deployments and reported successes. In the proposed system, we model sender/receiver peer assignments as an optimization problem. Optimized peer selection based on multiple utility factors, such as bandwidth availability, delays and connectivity compatibility, make it possible to achieve large source bandwidth savings and provide high quality of user experience. Clear benefits of our approach are observed when Network Address Translation constraints are present on the network. We have addressed key scalability issues of our platform by parallelizing the heuristic which is the core of our optimization engine and by implementing the resulting algorithm on commodity Graphic Processing Units (GPUs). The outcome is a Linear Sum Assignment Problem (LSAP) solver for time-constrained systems which produces near-optimal results and can be used for any instance of LSAP, i.e. not only in our system.   As part of this work, we also present our experience in working with Network Address Translators (NATs) traversal in peer-to-peer systems. Our contribution in this context is threefold. First, we provide a semi-formal model of state of the art NAT behaviors. Second, we use our model to show which NAT combinations can be theoretically traversed and which not. Last, for each of the combinations, we state which traversal technique should be used. Our findings are confirmed by experimental results on a real network. Finally, we address the problem of reproducibility in testing, debugging and evaluation of our peer-to-peer application. We achieve this by providing a software framework which can be transparently integrated with any already-existing software and which is able to handle concurrency, system time and network events in a reproducible manner.  
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  • Geli, Patricia (författare)
  • Modeling the Mechanism of Postantibiotic Effect and Determining Implications for Dosing Regimens
  • 2009
  • Ingår i: Journal of Mathematical Biology. - : Springer Science and Business Media LLC. - 0303-6812 .- 1432-1416. ; 59:5, s. 1416-1432
  • Tidskriftsartikel (refereegranskat)abstract
    • A stochastic model is proposed to explain one possible underlying mechanism of the postantibiotic effect (PAE). This phenomenon, of continued inhibition of bacterial growth after removal of the antibiotic drug, is of high relevance in the context of optimizing dosing regimens. One clinical implication of long PAE lies in the possibility of increasing intervals between drug administrations. The model describes the dynamics of synthesis, saturation and removal of penicillin binding proteins (PBPs). High fractions of saturated PBPs are in the model associated with a lower growth capacity of bacteria. An analytical solution for the bivariate probability of saturated and unsaturated PBPs is used as a basis to explore optimal antibiotic dosing regimens. Our finding that longer PAEs do not necessarily promote for increased intervals between doses, might help for our understanding of data provided from earlier PAE studies and for the determination of the clinical relevance of PAE in future studies.
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  • Tham, Mathilda, 1970- (författare)
  • Mode, tid och ekologi : system för hållbara modeögonblick
  • 2008. - 1
  • Ingår i: Grön design. - Stockholm : Naturskyddsföreningen. - 9789155820084 ; , s. 72-75
  • Bokkapitel (populärvet., debatt m.m.)abstract
    • Tid beskrivs i den västerländska samtiden ofta som lyx. Tid är också en viktig faktor i design. Som modedesigner kan man se tiden som ett slags meddesigner som hjälper till att slipa materialet och plaggets uttryck. Jag vill här visa hur förståelse av tid kan ge oss insikt i hållbarhetsstrategier för mode och på så sätt främja det riktigt långa tidsperspektivet – vår överlevnad.
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  • Åhlfeldt, Rose-Mharie, et al. (författare)
  • Security Issues in Health Care Process Integration : a Research-in-Progress Report
  • 2005
  • Ingår i: EMOI - INTEROP'05 Enterprise Modelling and Ontologies for Interoperability. - : CEUR.
  • Konferensbidrag (refereegranskat)abstract
    • The aim of this paper is to summarize our research and describe our current position in the areas of health care process integration and information security. Security is one of the important non functional aspect of interoperability within the INTEROP NoE. The paper will briefly introduce our work and some findings concerning security issues in process integration within the health care sector.
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