| 411. |
- Jönsson, Ulla-Britt, et al.
(författare)
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The production of the eosinophil proteins ECP and EPX/EDN are regulated in a reciprocal manner
- 2014
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Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 122:4, s. 283-291
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies showed that the biological activity and the eosinophil content of eosinophil cationic protein (ECP, RNase 3) are determined by single-nucleotide polymorphisms (SNPs) in the ECP (RNase3) gene. In this study, we report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (EPX/EDN, RNase2) and the association with the cellular contents of EPX/EDN and ECP. The genes were sequenced and the EPX/EDN405(G>C) rs2013109 SNPs were also determined by TaqMan 5nuclease allelic discrimination assay. ECP and EPX/EDN in purified eosinophils or in whole blood extracts were analysed by sensitive immunoassays. The study included 379 non-allergic and allergic subjects. The genotype prevalence of the EPX/EDN405(G>C) polymorphism was GG 59%, GC 36% and CC 6%. The cellular contents of ECP and EPX/EDN were related in a reciprocal fashion with the sums of the protein contents being constant. The contents were associated with the ECP562(G>C) rs2233860 and EPX/EDN405(G>C) gene polymorphisms. The cellular content of eosinophil peroxidase (EPO) was not associated with the ECP and EPX/EDN genotypes. The prevalence of the EPX/EDN405(G>C) genotypes and the contents of the proteins were similar in non-allergic and allergic subjects. The production and storage of the two ancestral proteins, ECP and EPX/EDN likely share common regulatory mechanisms, which result in opposing productions of the two proteins.
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| 412. |
- Jönsson, Ulf, et al.
(författare)
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MIPMANET-mobile IP for mobile ad hoc networks
- 2000
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Ingår i: 2000 First Annual Workshop on Mobile and Ad Hoc Networking and Computing (MobiHOC). - Boston, MA, USA. - 0780365348 ; , s. 75-85
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Konferensbidrag (refereegranskat)abstract
- Mobile ad hoc networking allows nodes to form temporary networks and communicate beyond the transmitter range by supporting multihop communication through IP routing. Routing in such networks is often reactive, i.e., performed on-demand, as opposed to Internet routing that is proactive. As ad hoc networks are formed on a temporary basis, any IP address should be allowed to appear in an ad hoc network. This paper presents MIPMANET, a solution for connecting an ad hoc network, in which on-demand routing is used, to the Internet. MIPMANET provides Internet access by using mobile IP with foreign agent care-of addresses and reverse tunneling. This allows nodes to enjoy the mobility services of mobile IP while at the same time the requirements on the ad hoc routing protocol are kept to a minimum. Simulations of MIPMANET have been performed in the Network Simulator 2. The ad hoc on-demand distance vector (AODV) routing protocol has been used for routing within the ad hoc network. These simulations show that the ability to choose the closest access point to the Internet is worth extra work, as less traffic is generated in the network resulting in lower delays and fewer dropped packets.
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| 413. |
- Kallstrom, Ann-Christine, et al.
(författare)
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17 beta-Hydroxysteroid dehydrogenase type 1 as predictor of tamoxifen response in premenopausal breast cancer
- 2010
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Ingår i: EUROPEAN JOURNAL OF CANCER. - : Elsevier Science B.V., Amsterdam.. - 0959-8049 .- 1879-0852. ; 46:5, s. 892-900
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Tidskriftsartikel (refereegranskat)abstract
- 17 beta-Hydroxysteroid dehydrogenases (17HSDs) are involved in the local regulation of sex steroids. 17HSD1 converts oestrone (El) to the more potent oestradiol (E2) and 17HSD2 catalyses the reverse reaction. The aim of this study was to investigate the expression of these enzymes in premenopausal breast cancers and to analyse if they have any prognostic or tamoxifen predictive value. Premenopausal patients with invasive breast cancer, stage II (UICC), were randomised to either 2 years of adjuvant tamoxifen (n = 276) or no tamoxifen (n = 288). The median follow-up was 13.9 years (range 10.5-17.5). The expression of 17HSD1 and 17HSD2 was analysed with immunohistochemistry using tissue microarrays. The enzyme expression level (-/+/++/+++) was successfully determined in 396 and 373 tumours, respectively. Women with hormone-receptor positive tumours, with low levels (-/+/++) of 17HSD1, had a 43% reduced risk of recurrence, when treated with tamoxifen (Hazard Ratio (HR) = 0.57; 95% confidence interval (CI), 0.37-0.86; p = 0.0086). On the other hand high expression (+++) of 17HSD1 was associated with no significant difference between the two treatment arms (HR = 0.91; 95% CI, 0.43-1.95; p = 0.82). The interaction between 17HSD1 and tamoxifen was significant during the first 5 years of follow-up (p = 0.023). In the cohort of systemically untreated patients no prognostic importance was observed for 17HSD1. We found no predictive or prognostic value for 17HSD2. This is the first report of 17HSD1 in a cohort of premenopausal women with breast cancer randomised to tamoxifen. Our data suggest that 17HSD1 might be a predictive factor in this group of patients.
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| 414. |
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| 415. |
- Kang, Huihui, et al.
(författare)
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Hyperfine quenching of the 3s3p^3P_0 state in Mg-like ions
- 2009
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Ingår i: Journal of Physics B. - : Bibliopolis, Edizioni di Filosofia e Scienze. - 0953-4075 .- 1361-6455. ; 42:19
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Tidskriftsartikel (refereegranskat)abstract
- Hyperfine quenching rates of the 3s3p 3P0 level in Mg-like ions were calculated using the GRASP2K package based on the multi-configuration Dirac–Hartree–Fock method. Valence and core-valence correlation effects were accounted for in a systematic way. Breit interactions and QED effects were included in the subsequent relativistic CI calculations. Calculated rates were compared with other theoretical values and with experiment, and a good agreement with the latest experimental value for the 27Al+ ion (Rosenband et al 2007 Phys. Rev. Lett. 98 220801) was found. Furthermore, we showed in detail the contributions from Breit interaction and QED effects to concerned physical properties. Finally, electronic data were presented in terms of a general scaling law in Z that, given isotopic nuclear spin and magnetic moment, allows hyperfine-induced decay rates to be estimated for any isotope along the isoelectronic sequence.
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| 416. |
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| 417. |
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| 418. |
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| 419. |
- Kopylov, Philippe, et al.
(författare)
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Norian SRS versus functional treatment in redisplaced distal radial fractures : A randomized study in 20 patients
- 2002
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Ingår i: Journal of Hand Surgery - British and European Volume. - : SAGE Publications. - 0266-7681 .- 1532-2211. ; 27 B:6, s. 538-541
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Tidskriftsartikel (refereegranskat)abstract
- We compared the use of Norian SRS, an injectable calcium phosphate bone cement, with functional treatment of redisplaced distal radial fractures in a prospective randomized study of 20 patients. The redisplaced fractures were either rereduced and stabilized by Norian SRS, or the displaced position was accepted and was not rereduced. All wrists were immobilized in a short-arm dorsal splint for 1 week, followed by a removable splint for another 3 weeks. The chosen primary effect variable was grip strength at 7 weeks, and this did not differ between the two treatment groups. The clinical results at 6 months in both groups were similar. We conclude that aggressive treatment of redisplaced fractures of the distal radius may be unnecessary in most women aged 50 years or more.
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| 420. |
- Korelis, P. T., et al.
(författare)
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Finite-size effects in amorphous Fe90Zr10/Al75Zr25 multilayers
- 2012
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 85:21, s. 214430-
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Tidskriftsartikel (refereegranskat)abstract
- The thickness dependence of the magnetic properties of amorphous Fe90Zr10 layers is explored using Fe90Zr10/Al75Zr25 multilayers. The Al75Zr25 layer thickness is kept at 40 angstrom, while the thickness of the Fe90Zr10 layers is varied between 5 and 20 angstrom. The thickness of the Al75Zr25 layers is sufficiently large to suppress any significant interlayer coupling. Both the Curie temperature and the spontaneous magnetization decrease nonlinearly with decreasing thickness of the Fe90Zr10 layers. No ferromagnetic order is observed in the multilayer with 5-angstrom Fe90Zr10 layers. The variation of the Curie temperature T-c with the Fe90Zr10 layer thickness t is fitted with a finite-size scaling formula [1 - T-c(t)/T-c(infinity)] = [(t - t')/t(0)](-lambda), yielding lambda = 1.2, and a critical thickness t' = 6.5 angstrom, below which the Curie temperature is 0.
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