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Sökning: LAR1:lu > (2010-2011) > Högskolan i Halmstad

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1.
  • Ahlqvist, Emma, et al. (författare)
  • High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
  • 2011
  • Ingår i: Human Molecular Genetics. - Oxford : Oxford University Press. - 0964-6906 .- 1460-2083. ; 20:15, s. 3031-3041
  • Tidskriftsartikel (refereegranskat)abstract
    • Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an inbred-outbred cross design, we identified and fine-mapped CIA loci on a genome-wide scale. Heterogeneous stock mice were first intercrossed with an inbred strain, B10.Q, to introduce an arthritis permitting MHCII haplotype. Homozygous H2(q) mice were then selected to set up an F(3) generation with fixed major histocompatibility complex that was used for arthritis experiments. We identified 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset and fine-mapped a number of previously mapped loci. © The Author 2011. Published by Oxford University Press. All rights reserved.
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2.
  • Albinsson, John, et al. (författare)
  • Combined use of Iteration, Quadratic Interpolation and an Extra Kernel for high-resolution 2D particle tracking : a first evaluation
  • 2010
  • Ingår i: 2010 ieee international ultrasonics symposium. - New York : IEEE Press. - 9781457703829 ; , s. 2000-2003
  • Konferensbidrag (refereegranskat)abstract
    • A novel 2D particle tracking method, that uses 1) iteration, 2) fast quadratic sub-pixel estimation (with only 28 multiplications per movement), and 3) a previous kernel, has been evaluated and compared with a full-search block-matching method. The comparison with high-frequency ultrasound data (40 MHz) was conducted in silico and on phantoms, which comprised lateral, diagonal, and ellipsoidal movement patterns with speeds of 0–15 mm/s. The mean tracking error was reduced by 68% in silico and 71% for the phantom measurements. When only sub-pixel estimation was used, the decrease in the tracking error was 61% in silico and 57% for the phantom measurements. As well as decreasing the tracking error, the new method only used 70% of the computational time needed by the full-search block-matching method. With a fast method having good tracking ability for high-frequency ultrasound data, we now have a tool to better investigate tissue movements and its dynamic functionality.
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3.
  • Argento, Daniela, et al. (författare)
  • The ‘externalisation’ of local public service delivery : experience in Italy and Sweden
  • 2010
  • Ingår i: International Journal of Public Policy. - Olney : InderScience Publishers. - 1740-0600 .- 1740-0619. ; 5:1, s. 41-56
  • Tidskriftsartikel (refereegranskat)abstract
    • In recent years, the local government sector in European countries has undergone important changes involving, among other things, the externalisation of local public service provision through various forms of corporatisation, public-public collaboration, public-private partnerships and contracting out. An important consequence of these institutional changes has been the recasting of local governance systems through the need for increased cooperation between public and private actors. This article addresses these matters with comparative reference to the experience in Italy and Sweden. In doing so, it considers local governments in their constitutional and legal contexts, leading to more detailed discussions of their externalisation initiatives and resultant organisational forms and governance arrangements. Issues of ownership have been important concerning the significance of 'community' and 'place' in the management of public affairs. © 2010 Inderscience Enterprises Ltd.
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4.
  • Avendal, Christel (författare)
  • Social Work in Ghana: Engaging Traditional Actors in Professional Practices
  • 2011
  • Ingår i: Journal of Comparative Social Work. - Stavanger : Stavanger University Library. - 0809-9936. ; 6:2, s. 106-124
  • Tidskriftsartikel (refereegranskat)abstract
    • In contemporary Ghana, the traditional system and professional social work operate as two parallel systems within the field of social work. The aim of this study was to investigate if and how the teaching of contemporary professional social work in Ghana takes into account traditional actors and practices. The traditional system includes extended family members and traditional authorities such as chiefs or family heads. It formed the social institution that protected and cared for the vulnerable before (Western) social work was introduced as a formal profession in Ghana. A 10-week ethnographic field study was conducted at the Department of Social Work at the University of Ghana. The study employed a qualitative, social constructionist approach, interpreting the results within a theoretical framework of social world theory. The empirical material consisted of interviews with students and teachers, participant observation at lectures, and various documents. The main findings of the study were that professional social workers and traditional actors can be seen as members of two subworlds – the subworld of professional social workers and the subworld of traditional actors. Students and teachers discuss interventions from the perspective of social workers and traditional actors. Their ability to take different perspectives seems to be crucial for localisation – the process by which social work is made relevant to local culture and traditions. The interviewees’ accounts reveal how localisation is not only about culture, but also about social structures and practical considerations. The poor state of the social work profession in Ghana affects interventions in a profound way.
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5.
  • Behrns, Ingrid, 1961, et al. (författare)
  • Aphasia and text writing
  • 2010
  • Ingår i: International journal of language and communication disorders. - New York, NY : John Wiley & Sons. - 1368-2822 .- 1460-6984. ; 45:2, s. 230-243
  • Tidskriftsartikel (refereegranskat)abstract
    • Background:Good writing skills are needed in almost every aspect of life today, and there is a growing interest in research into acquired writing difficulties. Most of the findings reported so far, however, are based on words produced in isolation. The present study deals with the production of entire texts.Aims:The aim was to characterize written narratives produced by a group of participants with aphasia.Methods & Procedures:Eight persons aged 28–63 years with aphasia took part in the study. They were compared with a reference group consisting of ten participants aged 21–30 years. All participants were asked to write a personal narrative titled ‘I have never been so afraid’ and to perform a picture-based story-generation task called the ‘Frog Story’. The texts were written on a computer.Outcome & Results: The group could be divided into participants with low, moderate, and high general performance, respectively. The texts written by the participants in the group with moderate and high writing performance had comparatively good narrative structure despite indications of difficulties on other linguistic levels.Conclusions & Implications:Aphasia appeared to influence text writing on different linguistic levels. The impact on overall structure and coherence was in line with earlier findings from the analysis of spoken and written discourse and the implication of this is that the written modality should also be included in language rehabilitation.
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6.
  • Bengtsson, Åsa, 1967- (författare)
  • Nyktra kvinnor : Folkbildare, företagare och politiska aktörer. Vita Bandet 1900-1930
  • 2011
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In this thesis the female Christian temperance union the White Ribbon is in focus. The White Ribbon was founded in Stockholm in 1900 and it was part of the international organization World’s Woman’s Christian Temperance Union (WWCTU). The organization’s ambition was to create a temperate and moral society, running a variety of philanthropic institutions and adult education, as well as non-alcohol serving restaurants.The aim of the thesis is to study the White Ribbon’s social and political commitment and its ideological approach during the first three decades of the 20th century. The White Ribboners’ ideological approach and culture are problematized in relation to the prevailing and predominant view on women. The organization’s monthly journal has been closely studied and the ideas and practical social and political commitment have been analyzed in a theoretical perspective of social movement theory, according to the Swedish sociologist Håkan Thörn’s methodological framework. This theoretical approach is an instrument to analyze what the White Ribbon identified to be social problems; what was considered to be the reasons for these problems; and what strategy the organization regarded to be the best way to deal with them in order to reach the prognosticated change.The analysis shows that the White Ribbon identified the predominant gender system and the bourgeois view on women as a primary social problem. The organization’s strategy was to eliminate the patriarchal order of the gender system and to change the attitude of people through adult education, information and persuasion. The White Ribbon participated in public debate pursuing temperance and women’s suffrage, and was a lobbyist proposing motions and demanding legislative reforms. The White Ribbon’s ideological approach, as well as their philanthropic activities emanated from a bourgeois ideal of conscientiousness and cultivation, and from an interest in social politics. This was in contrast to the bourgeois view of what the ideal woman should do. From the White Ribboners’ point of view, society could only prosper when women had the same rights as men, and could participate the public sphere and become involved in politics.The study shows that the organization worked hard for equality and democracy, pursuing a feminist and liberal ideology. The White Ribboners regarded themselves, and also acted, as political agents. They introduced and increased women’s possibilities for adult education. They initiated and provided social protection for alcohol addicted women, and for poor and fallen women and girls. These activities must be seen as forms of enterprises and the White Ribboners  as entrepreneurs, since these institutions were, in fact, innovations and models for solving problems in order to build a welfare system and to create a temperate and prosperous society. The thesis put forward arguments that the White Ribbon’s social and political work are political innovations and important elements in the process of democratization and, therefore, played an important part in this process.
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7.
  • Boberg, Pelle, et al. (författare)
  • The effect of high temperatures on seed germination of one native and two introduced conifers in Patagonia
  • 2010
  • Ingår i: Nordic Journal of Botany. - Chichester : Wiley-Blackwell. - 0107-055X .- 1756-1051. ; 28:2, s. 231-239
  • Tidskriftsartikel (refereegranskat)abstract
    • We examined the effect of thermal shock on the germination of seeds of three conifers, two introduced (Pseudotsuga menziesii and Pinus ponderosa), and one native to Patagonia (Araucaria araucana). Previous research has suggested increased susceptibility to invasions in burnt areas, and therefore, the effect of simulated fire (heat) on seed germination in these native and introduced species was compared. Seeds were heated to two different heat intensities (50°C and 100°C) for 1 or 5 min, which is within the temperature range reached in the upper soil layers during forest fires. Germination tests were then carried out in a growth chamber. The heat treatments had a negative effect on the germination of P. menziesii at temperatures of 100°C, and a negative effect on the germination of P. ponderosa at the temperature of 100°C and the exposure of 5 min. The heat treatments had no affect at all on A. araucana. The species with larger seeds (A. araucana) had higher survival rates after the thermal shocks. Also intraspecific differences in seed sizes possibly point at larger seeds surviving thermal shocks better than smaller seeds. In addition, thermal shock caused a delay in the onset of germination in the two introduced species, while it did not change the time for germination in A. araucana. © The Authors. Journal compilation © Nordic Journal of Botany 2010.
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8.
  • Bremander, Ann, et al. (författare)
  • Depression and age as predictors of patient-reported outcome in a multidisciplinary rehabilitation programme for chronic musculoskeletal pain.
  • 2011
  • Ingår i: Musculoskeletal Care. - : Wiley. - 1557-0681 .- 1478-2189. ; 9:1, s. 8-41
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. The recommended treatment for chronic musculoskeletal pain is multidisciplinary, with a cognitive approach. The aim of this study was to investigate health-related quality of life (HRQoL) outcome after a multidisciplinary treatment with a cognitive approach. Methods. A total of 131 subjects who participated in a multidisciplinary rehabilitation programme (2005-2008) were studied at baseline and after six months, using the Short Form Short Form 36-item Health Survey questionnaire (SF-36) as primary outcome (HRQoL), and the Hospital Anxiety and Depression Scale (HAD) and pain as secondary outcomes and possible baseline predictors for HRQoL. Results. Complete data were available for 97 subjects (85 women, mean age [SD] 44.6 [9.7] years). The SF-36 subscales physical function (PF), general health (GH), vitality (VT), social function (SF) and mental health (MH), the visual analogue scale for pain and the HAD improved significantly (p < 0.05) at follow-up compared with baseline. A pre-treatment probable depression (HAD score ≥11) was associated with a favourable outcome of the SF-36 subscales PF (odds ratio [OR] 5.6; p = 0.01), VT (OR 4.3; p = 0.02) and MH (OR 3.6; p = 0.02). A probable anxiety (HAD score ≥11) was associated with a favourable outcome of PF (OR 2.6; p = 0.05). There was an even stronger association for younger subjects (20-45 years), with probable depression scores at baseline and a favourable HRQoL outcome at follow up. Conclusion. This multidisciplinary rehabilitation programme, using a non-pharmacological cognitive approach, seemed to yield a better outcome concerning HRQoL measures in younger subjects with higher depression scores at baseline. This information is important for clinics when tailoring a multidisciplinary rehabilitation programme for patients with musculoskeletal chronic pain. Copyright © 2010 John Wiley & Sons, Ltd.
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9.
  • Bremander, Ann, 1957-, et al. (författare)
  • Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis
  • 2011
  • Ingår i: Arthritis care & research. - Hoboken, NJ : John Wiley & Sons. - 2151-464X .- 2151-4658. ; 63:4, s. 550-556
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To study the rate of common comorbidities and cardiovascular disease in patients with ankylosing spondylitis (AS) compared with the general population seeking health care.METHODS: This cohort study included 935 subjects (67% men) ages ≥20 years diagnosed with AS and the adult background population in Southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic codes for a select number of comorbidities commonly associated with AS and cardiovascular disease and risk factors. We obtained standardized morbidity-rate ratios (SMRs) by dividing the observed morbidity rate in AS patients by the expected rate based on the corresponding rate of the disease in the general population of the county seeking health care.RESULTS: The highest SMRs were found for uveitis (34.35, 95% confidence interval [95% CI] 28.55-40.98) and inflammatory bowel disease (9.28, 95% CI 7.07-11.97). Also, we found increased SMRs for ischemic heart diseases (2.20, 95% CI 1.77-2.70), hypertension (1.98, 95% CI 1.72-2.28), and diabetes mellitus (1.41, 95% CI 1.10-1.78). Furthermore, the SMRs for psoriasis, osteoporosis, and atrioventricular blocks were also statistically significantly elevated.CONCLUSION: Inflammatory diseases affecting the eye and the digestive system were the most notable comorbidities in AS patients, but the rate for cardiovascular disease was also high. Using comprehensive longitudinal population-based register data is a promising tool to evaluate the excess consultation rate and total burden of rheumatic disease on patients and society. Copyright © 2011 by the American College of Rheumatology.
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10.
  • Broberg, Pernilla, et al. (författare)
  • What explains variation in voluntary disclosure? : A study of the annual reports of corporations listed on the Stockholm Stock Exchange
  • 2010
  • Ingår i: Journal of Management and Governance. - New York, NY : Springer-Verlag New York. - 1385-3457 .- 1572-963X. ; 14:4, s. 351-377
  • Tidskriftsartikel (refereegranskat)abstract
    • The demand for information and transparency from listed corporations has recently increased. In spite of an increased demand for mandatory disclosures from regulators, corporations choose to voluntarily disclose additional information in order to satisfy demands from the capital market. However, the extent and content of information in those voluntary disclosures vary across corporations. The aim of this study is to explain the variation in the content of information in voluntary disclosures by listed corporations. The analyses are based on data collected from 431 annual reports from corporations listed on the Stockholm Stock Exchange during the years 2002 and 2005. The findings support explanations from agency theory and positive accounting theory that size and the debt ratio are positively correlated with the content of information in voluntary disclosures. Corporations with a high share of management ownership disclosed less information than corporations with a low share of management ownership. The study also shows that variations in voluntary disclosures can be explained by factors derived from institutional theory and ’international capital market pressures’. The results indicate that foreign ownership and international listing to some extent have a positive effect on the content of information in voluntary disclosures. Industry was another factor that had a significant influence on voluntary disclosures. One important finding is that regulation to some extent can stimulate voluntary disclosures; our results did not indicate an ’unintended chilling effect’ due to too much regulation. In general, the corporations disclosed more voluntary information after the introduction of IFRS. © 2009 Springer Science+Business Media, LLC.
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