| 1. |
- Grossi, Giorgio, et al.
(författare)
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The morning salivary cortisol response in burnout.
- 2005
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Ingår i: Journal of Psychosomatic Research. - : Elsevier. - 0022-3999 .- 1879-1360. ; 59:2, s. 103-111
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Tidskriftsartikel (refereegranskat)abstract
- The results of the present study indicate a dysregulation in hypothalamic-pituitary-adrenocortical axis (HPA axis) activity, characterised by elevated morning salivary cortisol levels, among female burnout patients. Among males, increased cortisol levels were observed among participants with moderate levels of burnout, but not among patients or healthy controls.
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| 2. |
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| 3. |
- Emanuelsson, O., von Heijne, G., Elofsson, A., Cristóbal, S.
(författare)
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In silico prediction of the peroxisomal proteome in fungi, plants and animals
- 2003
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Ingår i: J. Mol. Biol.. ; 330, s. 443-456
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Tidskriftsartikel (refereegranskat)abstract
- In an attempt to improve our abilities to predict peroxisomal proteins, we have combined machine-learning techniques for analyzing peroxisomal targeting signals (PTS1) with domain-based cross-species comparisons between eight eukaryotic genomes. Our resul
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| 4. |
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| 5. |
- Digre, Andreas, 1987-
(författare)
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Implications of Heparan Sulfate and Heparanase in Inflammatory Diseases
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Heparan sulfate (HS), an unbranched sulfated carbohydrate chain, and the HS-degrading enzyme heparanase play important roles in physiological and pathological processes during all stages of life, from early embryogenesis to ageing. Accumulated information shows that HS and heparanase are involved in inflammatory processes and associated diseases, e.g. rheumatoid arthritis (RA) and Alzheimer’s disease.In this thesis I have investigated the role of HS and heparanase (Hpa) in inflammatory-related pathologies. In the first project, Hpa overexpressing mice (Hpa-tg) were induced with a murine model of RA. We found a pro-inflammatory role of Hpa through enhancing the activity of T-cells and innate immune cells, which contributed to an augmented severity of clinical symptoms in the Hpa-tg mice.In my second project, we revealed co-current interaction of heparin with both ApoA1 and SAA of HDL isolated from plasma of inflamed mouse. Mass spectrometry analysis indicated close proximity of ApoA1 and SAA on the HDL surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA.In my third project, we investigated the role of Hpa in AA amyloid formation and resolution in mice in a model of AA-amyloidosis. We found a similar degree of amyloid formation in Hpa-KO mice compared to the wildtype control mice, but the resolution process was faster in Hpa-KO mice. The rapid clearance of deposited SAA in Hpa-KO mice was associated with upregulated expression of matrix metalloproteases. The results suggest an associated function of ECM proteases with heparanase in the process of AA amyloid resolution.In my fourth project, we found that overexpression of heparanase impaired inflammation associated beta amyloid (Aβ) clearance in the brain of an Alzheimer’s disease mouse model. Examination of the cytokine profile of brain lysates revealed an overall lower inflammatory reaction in the double transgenic (tgHpa*Swe) mice compared to single APP-tg (tg-Swe) mice in response to LPS-induced inflammation.
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| 6. |
- Digre, Andreas, 1987-, et al.
(författare)
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Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
- 2017
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is expressed at a low level in normal organs; however, elevated expression of heparanase has been detected in several inflammatory conditions, e.g. in the synovial joints of rheumatoid arthritis (RA) patients. Herein, we have applied the model of collagen-induced arthritis (CIA) to transgenic mice overexpressing human heparanase (Hpa-tg) along with wildtype (WT) mice. About 50 % of the induced animals developed clinical symptoms, i.e. swelling of joints, and there were no differences between the Hpa-tg and WT mice in the incidence of disease. However, Hpa-tg mice displayed an earlier response and developed more severe symptoms. Examination of cells from thymus, spleen and lymph nodes revealed increased innate and adaptive immune responses of the Hpa-tg mice, reflected by increased proportions of macrophages, antigen presenting cells and plasmacytoid dendritic cells as well as Helios-positive CD4+ and CD8+ T cells. Furthermore, splenic lymphocytes from Hpa-tg mice showed higher proliferation activity. Our results suggest that elevated expression of heparanase augmented both the innate and adaptive immune system and propagated inflammatory reactions in the murine RA model.
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| 7. |
- Siegel, Aki
(författare)
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Study Abroad in Sweden : Japanese Exchange Students’ Perspectives of Language Use in University EMI Courses
- 2022
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Ingår i: Languages. - : MDPI. - 2226-471X. ; 7:1, s. 1-16
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Tidskriftsartikel (refereegranskat)abstract
- With the availability of English as a Medium of Instruction (EMI) courses, an increasing number of international students have been joining Swedish universities. However, the language use in Swedish EMI courses may display unique features; while many Swedish students have high English language proficiency, code-switching between Swedish and English is reported as a common practice by both lecturers and students, even when international students are present. Moreover, the term “international students” is often used to include students of various statuses and linguistic abilities, and the experiences and perspectives of short-term exchange students towards the language use in Swedish EMI courses are rarely documented. The current study investigates the perspectives of short-term exchange students from Japan enrolled in EMI courses at a university in Sweden. Questionnaire and focus group interview confirmed previous studies regarding the language-use practices in the classrooms. Moreover, the rate of speech, turn-taking, and background knowledge were found to hinder the learning and participation of the exchange students. The findings suggest the need to raise awareness of the language practices in Swedish EMI courses to students, lecturers, and other universities in order to support the learning experience of short-term exchange students
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| 8. |
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| 9. |
- Rist, Lucy, et al.
(författare)
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Applying resilience thinking to production ecosystems
- 2014
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Ingår i: Ecosphere. - 2150-8925 .- 2150-8925. ; 5:6, s. 73-
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Tidskriftsartikel (refereegranskat)abstract
- Production ecosystems typically have a high dependence on supporting and regulating ecosystem services and while they have thus far managed to sustain production, this has often been at the cost of externalities imposed on other systems and locations. One of the largest challenges facing humanity is to secure the production of food and fiber while avoiding long-term negative impacts on ecosystems and the range of services that they provide. Resilience has been used as a framework for understanding sustainability challenges in a range of ecosystem types, but has not been systematically applied across the range of systems specifically used for the production of food and fiber in terrestrial, freshwater, and marine environments. This paper applied a resilience lens to production ecosystems in which anthropogenic inputs play varying roles in determining system dynamics and outputs. We argue that the traditional resilience framework requires important additions when applied to production systems. We show how sustained anthropogenic inputs of external resources can lead to a "coercion'' of resilience and describe how the global interconnectedness of many production systems can camouflage signals indicating resilience loss.
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| 10. |
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