| 1. |
- Agrell, Cecilia, et al.
(författare)
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Evidence of Latitudinal Fractionation of Polychlorinated Biphenyl Congeners along the Baltic Sea Region
- 1999
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Ingår i: Environmental Science & Technology. - : American Chemical Society (ACS). - 1520-5851 .- 0013-936X. ; 33:8, s. 1149-1156
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Tidskriftsartikel (refereegranskat)abstract
- Annual cycles of the atmospheric concentrations of PCBs were determined at 16 (mostly rural) stations around the Baltic Sea between 1990 and 1993. The concentration levels of individual congeners were found to be influenced by their physical-chemical properties, ambient temperature, and geographical location. Median levels of PCBs were similar at all stations except at one urban site near Riga. A latitudinal gradient with higher levels in the south was found for the sum of PCB as well as for individual congeners, and the gradient was more pronounced for the low volatility congeners. As a result, the high volatility congeners increased in relative importance with latitude. Generally, PCB concentrations increased with temperature, but slopes of the partial pressure in air versus reciprocal temperature were different between congeners and between stations. In general, the low volatility congeners were more temperature dependent than the high volatility PCB congeners. Steep slopes at a sampling location indicate that the concentration in air is largely determined by diffusive exchange with soils. Lack of a temperature dependence may be due to the influence of long-range transported air masses at remote sites and due to the episodic or random nature of PCB sources at urban sites.
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| 2. |
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| 3. |
- Berglund, Jonas, et al.
(författare)
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Hotspots of biased nucleotide substitutions in human genes
- 2009
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 7:1, s. e26-
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Tidskriftsartikel (refereegranskat)abstract
- Genes that have experienced accelerated evolutionary rates on the human lineage during recent evolution are candidates for involvement in human-specific adaptations. To determine the forces that cause increased evolutionary rates in certain genes, we analyzed alignments of 10,238 human genes to their orthologues in chimpanzee and macaque. Using a likelihood ratio test, we identified protein-coding sequences with an accelerated rate of base substitutions along the human lineage. Exons evolving at a fast rate in humans have a significant tendency to contain clusters of AT-to-GC (weak-to-strong) biased substitutions. This pattern is also observed in noncoding sequence flanking rapidly evolving exons. Accelerated exons occur in regions with elevated male recombination rates and exhibit an excess of nonsynonymous substitutions relative to the genomic average. We next analyzed genes with significantly elevated ratios of nonsynonymous to synonymous rates of base substitution (dN/dS) along the human lineage, and those with an excess of amino acid replacement substitutions relative to human polymorphism. These genes also show evidence of clusters of weak-to-strong biased substitutions. These findings indicate that a recombination-associated process, such as biased gene conversion (BGC), is driving fixation of GC alleles in the human genome. This process can lead to accelerated evolution in coding sequences and excess amino acid replacement substitutions, thereby generating significant results for tests of positive selection.
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| 4. |
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| 5. |
- Cederborg, Ann-Christin, 1952-, et al.
(författare)
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Research expanding current understandings of bullying in Sweden
- 2016
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Ingår i: Pensamiento Psicológico. - : Pontificia Universidad Javeriana. - 1657-8961. ; 14:1, s. 131-146
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Tidskriftsartikel (refereegranskat)abstract
- This paper discusses the on-going research on the phenomenon of bullying in the Department of Child andYouth Studies at Stockholm University. The paper describes the reasons, and how to contribute with anunderstanding of bullying as a social group phenomenon, and specifically focuses on inductive ethnographicand cyberethnographic approaches toward peer-to-peer interactions in schools, preschools and on theInternet. The understanding of this phenomenon is based on a Swedish interdisciplinary approach whichincludes children’s perspectives. The objective is to explore bullying as a complex social group phenomenonwhich allows for a focus on the process of bullying, thus creating an opportunity for the enhancement of theunderstanding of inter- and intra-connected actions and perspectives. This article is intended to contribute toa discussion on a broadening of the conceptualization of the phenomenon of bullying.
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| 6. |
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| 7. |
- Ferrando, Carlos, et al.
(författare)
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A noninvasive postoperative clinical score to identify patients at risk for postoperative pulmonary complications : the Air-Test Score
- 2020
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Ingår i: Minerva Anestesiologica. - : EDIZIONI MINERVA MEDICA. - 0375-9393 .- 1827-1596. ; 86:4, s. 404-415
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Postoperative pulmonary complications (PPCs) negatively affect morbidity, healthcare costs and postsurgical survival. Preoperative and intraoperative peripheral oxyhemoglobin saturation (SpO(2)) levels are independent risk factors for postoperative pulmonary complications (PPCs). The air-test assesses the value of SpO(2) while breathing room-air. We aimed at building a clinical score that includes the air-test for predicting the risk for PPCs. METHODS: This is a development and validation study in patients -randomly divided into two cohorts- from a large randomized clinical trial (iPROVE) that enrolled 964 intermediate-to-high risk patients scheduled for abdominal surgery. Arterial oxygenation was assessed on room-air in the preoperative period (preoperative air-test) and 3h after admission to the postoperative care unit (postoperative air-test). The air-test was defined as positive or negative if SpO(2) was <= 96% or >96%, respectively. Positive air-tests were stratified into weak (93-96%) or strong (<93%). The primary outcome was a composite of moderate-to-severe PPCs during the first seven postoperative days. RESULTS: A total of 902 patients were included in the final analysis (542 in the development cohort and 360 in the validation cohort). Regression analysis identified five independent risk factors for PPC: age. type of surgery, pre- and postoperative air-test, and atelectasis. The area under the receiver operating characteristic curve (AUC) was 0.79 (95% CI: 0.75-0.82) when including these five independent predictors. We built a simplified score termed "air-test score" by using only the pre- and postoperative SpO(2) , resulting in an AUC of 0.72 (95% CI: 0.67-0.76) for the derivation and 0.72 (95% CI: 0.66-0.78) for the validation cohort, respectively. The air-test score stratified patients into four levels of risk, with PPCs ranging from <15% to >75%. CONCLUSIONS: The simple, non-invasive and inexpensive bedside air-test score, evaluating pre- and postoperatively SpO(2) measured on room-air, helps to predict the risk for PPCs.
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| 8. |
- Gibson, David V., et al.
(författare)
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Developing the entrepreneurial university : Architecture and institutional theory
- 2017
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Ingår i: World Technopolis Review. - : Korea Institute of Science and Technology Information. - 2234-4594 .- 2508-8882. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Given the diverse environmental contexts of universities worldwide there is a need for a theoretical orientation that addresses the entrepreneurial university in a range of settings. Applying the institutional perspective this research explores how universities are strongly influenced by, as well as active influencers in, their surrounding environment. To do this, we examine case narratives of two universities in each of the following countries: Norway, Sweden, Finland, the UK, and the U.S. Analysis focuses on five entrepreneurial dimensions as defined by Nelles and Vorley (2010a): Structures, Systems, Leadership, Strategies, and Culture while examining the impact of regional and national context at regulative, normative, and cognitive levels of analysis. We address two research questions: How do universities interact with their institutional context in developing entrepreneurially and what actors and forces are most important in motivating institutional change in developing a university's entrepreneurial architecture?
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| 9. |
- Gidlöf, Olof, et al.
(författare)
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Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone
- 2019
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Extracellular vesicles (EVs) are submicron, membrane-enclosed particles that are released from cells in various pathophysiological states. The molecular cargo of these vesicles is considered to reflect the composition of the cell of origin, and the EV proteome is therefore a potential source of biomarkers for various diseases. Our aim was to determine whether EVs isolated from plasma provide additional diagnostic value or improved pathophysiological understanding compared to plasma alone in the context of myocardial infarction (MI). A panel of proximity extension assays (n = 92) was employed to analyze EV lysates and plasma from patients with MI (n = 60) and healthy controls (n = 22). After adjustment for multiple comparisons, a total of 11 dysregulated proteins were identified in EVs of MI patients compared to the controls (q < 0.01). Three of these proteins: chymotrypsin C (CTRC), proto-oncogene tyrosine-protein kinase SRC (SRC) and C-C motif chemokine ligand 17 (CCL17) were unaltered in the corresponding plasma samples. As biomarkers for MI, rudimentary to no evidence exists for these proteins. In a separate group of patients with varying degrees of coronary artery disease, the decrease in EV-associated (but not plasma-related) SRC levels was confirmed by ELISA. Confirmation of the presence of SRC on EVs of different sizes and cellular origins was performed with ELISA, flow cytometry and nanoparticle tracking analysis. In conclusion, the data revealed that despite a similarity in the EV and plasma proteomes, analysis of isolated EVs does indeed provide additional diagnostic information that cannot be obtained from plasma alone.
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