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Sökning: WFRF:(Jönsson Per)

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51.
  • Barrett, Jennifer H., et al. (författare)
  • Genome-wide association study identifies three new melanoma susceptibility loci
  • 2011
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1108-1113
  • Tidskriftsartikel (refereegranskat)abstract
    • We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 x 10(-9)), an SNP in MX2 (rs45430, P = 2.9 x 10-9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 x 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 x 10(-7) under a fixed-effects model and P = 1.2 x 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
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52.
  • Beck, P S A, et al. (författare)
  • A ground-validated NDVI dataset for monitoring vegetation dynamics and mapping phenology in Fennoscandia and the Kola peninsula
  • 2007
  • Ingår i: International Journal of Remote Sensing. - : Informa UK Limited. - 1366-5901 .- 0143-1161. ; 28:19, s. 4311-4330
  • Tidskriftsartikel (refereegranskat)abstract
    • An NDVI dataset covering Fennoscandia and the Kola peninsula was created for vegetation and climate studies, using Moderate Resolution Imaging Spectroradiometer 16-day maximum value composite data from 2000 to 2005. To create the dataset, ( 1) the influence of the polar night and snow on the NDVI values was removed by replacing NDVI values in winter with a pixel- specific NDVI value representing the NDVI outside the growing season when the pixel is free of snow; and ( 2) yearly NDVI time series were modelled for each pixel using a double logistic function defined by six parameters. Estimates of the onset of spring and the end of autumn were then mapped using the modelled dataset and compared with ground observations of the onset of leafing and the end of leaf fall in birch, respectively. Missing and poor-quality data prevented estimates from being produced for all pixels in the study area. Applying a 5 km x 5 km mean filter increased the number of modelled pixels without decreasing the accuracy of the predictions. The comparison shows good agreement between the modelled and observed dates ( root mean square error = 12 days, n = 108 for spring; root mean square error = 10 days, n = 26, for autumn). Fennoscandia shows a range in the onset of spring of more than 2 months within a single year and locally the onset of spring varies with up to one month between years. The end of autumn varies by one and a half months across the region. While continued validation with ground data is needed, this new dataset facilitates the detailed monitoring of vegetation activity in Fennoscandia and the Kola peninsula.
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53.
  • Beery, Thomas, et al. (författare)
  • Perceptions of the ecosystem services concept: Opportunities and challenges in the Swedish municipal context
  • 2016
  • Ingår i: Ecosystem Services. - : Elsevier BV. - 2212-0416. ; 17, s. 123-130
  • Tidskriftsartikel (refereegranskat)abstract
    • A current focus of ecosystem services (ES) implementation is on the municipal level of government where international and national legislation and policies have to be translated into practice. Given this focus, an understanding of perceptions within municipalities of the ES concept is crucial to support the implementation process. Against this background, this paper examines the perceptions of Swedish municipal stakeholders for the ES concept. A 2013 Swedish federal mandate that states that the values of ecosystem services should be considered in relevant decision-making processes, provides a timely context. Current perceptions, preconditions and awareness are explored via interviews and analyses. The results show that the views on the ecosystem services concept and its usefulness are generally very positive. Conceptual knowledge use is perceived as important as is the recognition of monetary valuation of ES. However, clarification of the distinction between implicit and explicit use of the concept by stakeholders is needed. Finally, results indicate that a deeper understanding of monetary valuation of ecosystem services by municipal staff members is connected with a more critical view on monetary valuation. It is concluded that detailed and clear definitions and guidelines are needed in order to support the process of implementing ES in municipalities.
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54.
  • Bengtsson, Peter, et al. (författare)
  • Energy structure and transition rates in the Ne-like sequence from relativistic CI calculations
  • 2012
  • Ingår i: Europhysics Conference Abstracts;36C. - : European Physical Society. ; , s. 128-128
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Atomic data are important in astrophysical applications and transition rates can be used in the determination of element abundances and plasma diagnostics. To provide for the extensive data needs a number of general computer codes such as SUPERSTRUCTURE, CIV3, and ATSP2K have been developed. As an alternative to these codes, which all rely on the Breit-Pauli approximation, the fully relativistic GRASP2K code can be used. GRASP2K is based on the multiconfiguration Dirac-Hartree-Fock method and implements a bi-orthogonal transformation method that permits initial and final states in a transition array to be optimized separately, which, in many cases, leads to more accurate values of the resulting rates. The GRASP2K package also contains modules to compute diagonal and off-diagonal hyperfine interaction constants, isotope shifts, Land´e gJ factors, and splittings of magnetic sub-state in intermediate and strong magnetic fields. In this work, GRASP2K has been applied to provide highly accurate spectroscopic data for ions in the Ne-like sequence between Mg III and Kr XXVII. Valence, core-valence, and core-core correlation effects were accounted for through SD-MR expansions to increasing sets of active orbitals. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%. For ions with no available experimental energy levels the calculated values should be most valuable in various applications. The high accuracy of the calculated energies makes it possible, in some cases, to to point out experimental values that are in error. Babushkin (length) and Coulomb (velocity) forms of transition rates are computed and agree to within a few percent for the majority of the allowed transitions. Computed lifetimes for states belonging to the 2p33s and 2p53d configurations are in good agreement with values from beam-foil measurements as well as from accurate MCHF Breit-Pauli calculations.
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55.
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56.
  • Berander, Patrik, et al. (författare)
  • Hierarchical Cumulative Voting (HCV) Prioritization of Requirements in Hierarchies
  • 2006
  • Ingår i: International Journal of Software Engineering & Knowledge Engineering. - Singapore : World Scientific Publishing Company. - 0218-1940. ; 16:6, s. 819-849
  • Tidskriftsartikel (refereegranskat)abstract
    • Decision support in requirements engineering is an activity that plays an important role in enabling the delivery of value to stakeholders. Requirements prioritization has been identified as an integral (and important) part of requirements negotiation and release planning in incremental software development, which makes prioritization a key issue in requirements engineering decision support. The Analytical Hierarchy Process (AHP) has for long been considered as the technique to use when prioritizing requirements on a ratio scale. Several studies have reported positively about AHP, but lately a number of studies have also reported about weaknesses, without identifying any better ratio-scale alternatives. In this paper, the strengths and weaknesses of AHP and another ratioscale prioritization technique, Cumulative Voting (CV), are compared. Based on this comparison, a new technique for prioritizing hierarchically structured requirements on a ratio scale is presented, called Hierarchical Cumulative Voting (HCV). HCV addresses the weaknesses of AHP while inheriting the strengths of CV. The suitability of HCV is discussed theoretically as well as in the light of empirical results from using HCV and CV in industrial settings. It is concluded that HCV seems very promising, but additional empirical studies are needed to address some of the open questions about the technique.
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57.
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58.
  • Bergh, Cecilia, et al. (författare)
  • In the eye of both patient and spouse: memory is poor 1 to 2 years after coronary bypass and angioplasty.
  • 2002
  • Ingår i: Annals of Thoracic Surgery. - 1552-6259. ; 74:3, s. 689-693
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The study aimed to investigate patient and spouse perception of cognitive functioning 1 to 2 years after coronary artery bypass grafting. METHODS: Seventy-six married patients who had undergone coronary artery bypass grafting were selected and sex- and age-matched with 75 concurrent married patients who had undergone percutaneous transluminal coronary angioplasty. Couples received a letter of explanation and then completed telephone interviews. Forty-seven questions assessed memory, concentration, general health, social functioning, and emotional state. Response choices were: improved, unchanged, or deteriorated function after coronary artery bypass grafting/percutaneous transluminal coronary angioplasty. RESULTS: Patients who had undergone coronary artery bypass grafting did not differ in subjective ratings on any measure from patients who had undergone percutaneous transluminal coronary angioplasty. There were no differences between spouses in the respective groups; spouse ratings also did not differ from patient ratings. Only in memory function did patients and spouses report a postprocedural decline. CONCLUSIONS: No subjective differences were found in patients who had undergone either coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Spouse ratings agreed with each other and with patient ratings. Positive correlations were found between the questionnaire factors, suggesting that perceived health and well-being are associated with subjective cognition.
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59.
  • Bergh, Cecilia, 1972-, et al. (författare)
  • In the eye of both patient and spouse: memory is poor 1 to 2 years after coronary bypass and angioplasty
  • 2002
  • Ingår i: Annals of Thoracic Surgery. - : Elsevier BV. - 0003-4975 .- 1552-6259. ; 74:3, s. 689-693
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. The study aimed to investigate patient and spouse perception of cognitive functioning 1 to 2 years after coronary artery bypass grafting.Methods. Seventy-six married patients who had undergone coronary artery bypass grafting were selected and sex- and age-matched with 75 concurrent married patients who had undergone percutaneous transluminal coronary angioplasty. Couples received a letter of explanation and then completed telephone interviews. Forty-seven questions assessed memory, concentration, general health, social functioning, and emotional state. Response choices were: improved, unchanged, or deteriorated function after coronary artery bypass grafting/percutaneous transluminal coronary angioplasty.Results. Patients who had undergone coronary artery bypass grafting did not differ in subjective ratings on any measure from patients who had undergone percutaneous transluminal coronary angioplasty. There were no differences between spouses in the respective groups; spouse ratings also did not differ from patient ratings. Only in memory function did patients and spouses report a postprocedural decline.Conclusions. No subjective differences were found in patients who had undergone either coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Spouse ratings agreed with each other and with patient ratings. Positive correlations were found between the questionnaire factors, suggesting that perceived health and well-being are associated with subjective cognition.
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60.
  • Bergh, Jonas, et al. (författare)
  • FACT : An Open-Label Randomized Phase III Study of Fulvestrant and Anastrozole in Combination Compared With Anastrozole Alone as First-Line Therapy for Patients With Receptor-Positive Postmenopausal Breast Cancer
  • 2012
  • Ingår i: Journal of Clinical Oncology. - Alexandria, VA : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:16, s. 1919-1925
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To compare the effect of therapy with anastrozole versus a combination of fulvestrant and anastrozole in women in first relapse of endocrine-responsive breast cancer. Patients and Methods: Postmenopausal women, or premenopausal women receiving a gonadotropin-releasing hormone agonist, with estrogen receptor– and/or progesterone receptor–positive disease at first relapse after primary treatment of localized disease were open-label randomly assigned to a fulvestrant loading dose (LD) regimen followed by monthly injection plus 1 mg of anastrozole daily or to 1 mg of anastrozole daily alone. The primary end point was time to progression (TTP). Results: In all, 514 women were randomly assigned to fulvestrant plus anastrozole (experimental arm; n = 258) or anastrozole (standard arm; n = 256). Approximately two thirds had received adjuvant antiestrogens, but only eight individuals had received an aromatase inhibitor. Median TTP was 10.8 and 10.2 months in the experimental versus standard arm, respectively (hazard ratio [HR] = 0.99; 95% CI, 0.81 to 1.20; P = .91); median overall survival was 37.8 and 38.2 months, respectively (HR = 1.0; 95% CI, 0.76 to 1.32; P = 1.00). Incidences of prespecified adverse events (AEs) were similar. Hot flashes were more common in the experimental arm: 63 patients (24.6%) versus 35 patients (13.8%) in the standard arm (P = .0023). Death owing to AEs was reported in 11 (4.3%) and five patients (2.0%) in the experimental versus standard arm, respectively. Conclusion: Fulvestrant (250 mg + LD regimen) in combination with anastrozole offered no clinical efficacy advantage over anastrozole monotherapy in this population of individuals with a relatively high proportion of previous adjuvant antiestrogen exposure.
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