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Träfflista för sökning "LAR1:gu ;pers:(Gustafson Deborah 1966);lar1:(gu)"

Search: LAR1:gu > Gustafson Deborah 1966 > University of Gothenburg

  • Result 81-90 of 105
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81.
  • Sigström, Robert, 1982, et al. (author)
  • A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds.
  • 2011
  • In: Journal of anxiety disorders. - : Elsevier BV. - 1873-7897 .- 0887-6185. ; 25:1, s. 148-53
  • Journal article (peer-reviewed)abstract
    • This population-based study reports on the prevalence and characteristics of specific phobia (SP) and phobic fears in an elderly population. A representative population sample of Swedish 70-year-olds without dementia (N = 558) was examined using semi-structured interviews. Phobic fears included fear of animals, natural environment, specific situations, blood-injection-injury and 'other'. Mental disorders, including SP, were diagnosed according to DSM-IV. Phobic fears (71.0% vs. 37.9%) and SP (13.8% vs. 4.5%) were more common in women than in men. Among those with phobic fears, more than 80% reported onset before age 21. Of those with SP, 35.7% had another DSM-IV diagnosis compared to 8.5% of those reporting no fear. Fear of specific situations and 'other' fears were related to SP and other anxiety disorders. SP was related to lower global functioning. We conclude that specific phobia in the elderly should receive attention from health professionals as it is common and associated with a decrease in global functioning.
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82.
  • Sigström, Robert, 1982, et al. (author)
  • The prevalence of psychotic symptoms and paranoid ideation in non-demented population samples aged 70-82 years.
  • 2009
  • In: International journal of geriatric psychiatry. - : Wiley. - 1099-1166 .- 0885-6230. ; 24, s. 1413-9
  • Journal article (peer-reviewed)abstract
    • OBJECTIVES: Recent population(Q3) studies have reported an approximate 10% prevalence of psychotic symptoms among elderly aged 85 years and older. Psychotic symptoms may be less prevalent among younger elderly. We examined the prevalence of psychotic symptoms in a population-based sample of non-demented elderly aged 70-82 years. METHODS: A systematic Swedish population sample of 894 non-demented elderly (response rate 68%) representing three birth cohorts (340 women and 224 men aged 70 years and 330 women aged 78 and 82 years) was examined using the Comprehensive Psychopathological Rating Scale (CPRS), during a semi-structured psychiatric interview. A key informant interview was also conducted. Psychotic symptoms were classified according to the DSM-IV Glossary of technical terms. RESULTS: The 1-year prevalence of any psychotic symptom was 0.9% among non-demented women and men aged 70 years, and 1.2% among women aged 78 and 82 years. Psychotic symptoms were not related to sex or age. The prevalence of paranoid ideation was 1.0%. Among women, any paranoid symptom (persecutory delusions or paranoid ideation) was more common in 70-year-olds (2.6%) than in 78-82-year-olds (0.6%) (p = 0.04). CONCLUSIONS: Psychotic symptoms affected only 1% of this non-demented population aged 70, 78 and 82 years, which is lower than the 7-10% previously found among 85- and 95-year-olds. This might reflect a lower prevalence of psychotic symptoms compared to older elderly or secular changes resulting in lower prevalence of psychotic symptoms in later-born birth cohorts. Copyright (c) 2009 John Wiley & Sons, Ltd.
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83.
  • Simoni, M, et al. (author)
  • Prevalence of CT-detected cerebral abnormalities in an elderly Swedish population sample.
  • 2008
  • In: Acta neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 118:4, s. 260-7
  • Journal article (peer-reviewed)abstract
    • OBJECTIVE: To measure the prevalence of computed tomography (CT)-detected cerebral lesions in a population-based sample of elderly persons living in Göteborg, Sweden. METHODS: Cerebral CT-scans were performed in the case of 466 women (mean age 74.3 +/- 5.1 years) and 191 70-year-old men. A single rater assessed white matter lesions (WML) using four different scales, lacunar lesions, large infarcts, cortical atrophy, and basal ganglia calcifications. RESULTS: White matter lesions frequency assessed by different scales ranged between 54.5% and 68.5%. Lacunar lesions were detected in 46.7% (30.1% had lacunes >5 mm) and cerebral infarcts in 3.0% of participants. Overall, 72.8% of participants evidenced cerebral vascular abnormalities. Severe cortical atrophy was more common in temporal (6.4%) and frontal (6.7%) lobes, than in parietal (1.7%) and occipital (1.1%) lobes. Basal ganglia calcifications were found in 38.7% of participants. WML, lacunar lesions, large infarcts, and degree of cortical atrophy correlated positively with age. More lacunes, basal ganglia calcifications, and occipital lobe atrophy were associated with male gender. CONCLUSIONS: Vascular and other brain lesions are very common on CT-scan in an elderly population, but large vascular lesions are rare. This study provides the first reference for the prevalence of CT-detected abnormalities in an elderly Swedish population.
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84.
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85.
  • Sjögren, Magnus, et al. (author)
  • Cholesterol and Alzheimer's disease--is there a relation?
  • 2006
  • In: Mechanisms of ageing and development. - : Elsevier BV. - 0047-6374. ; 127:2, s. 138-47
  • Research review (peer-reviewed)abstract
    • The predominating theory on the pathophysiology of Alzheimer's disease (AD) concerns the mis-metabolism of amyloid precursor protein (APP). As a result of this mis-metabolism, there is an increased production of the 42 amino acid form of beta-amyloid (Abeta42) that rapidly will form oligomers that initiates a cascade of events leading to the accumulation of amyloid plaques. Commonly recognised as vascular factors, hypertension, hypercholesterolemia and diabetes and the inheritance of the epsilon4 allele of the APOE gene, are also risk factors for AD. These risks have been found to promote the production of Abeta42. An association between cholesterol and the development of AD was suggested in the early 1990s and ever since, an increasing amount of research has confirmed that there is a link between cholesterol and the development of AD. A high cholesterol levels in mid-life is a risk for AD and statins, i.e., cholesterol-lowering drugs, reduce this risk. Statins may not only inhibit enzymes involved in the endogenous synthesis of cholesterol but also affect enzymes involved in Abeta metabolism, i.e., alpha-secretase and beta-secretase. This normalises the breakdown of APP thereby promoting the non-amyloidogenic pathway. In this review, investigations focusing on cholesterol and Alzheimer's disease are presented.
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86.
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87.
  • Skoog, Ingmar, 1954, et al. (author)
  • Control of vascular risk factors
  • 2009
  • In: Vascular Cognitive Impairment in Cinical Practice. Wahlund L-O, Erkinjuntti T, Gauthier S, eds. - Cambridge : Cambridge University Press. ; , s. 220-33
  • Book chapter (other academic/artistic)
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88.
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89.
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90.
  • Skoog, Ingmar, 1954, et al. (author)
  • Update on hypertension and Alzheimer's disease.
  • 2006
  • In: Neurological research. - 0161-6412. ; 28:6, s. 605-11
  • Research review (peer-reviewed)abstract
    • Several studies report that blood pressure is increased in victims of Alzheimer's disease (AD) decades before the onset of the disease. Years before onset of Alzheimer's disease, blood pressure start to decrease and continues to decrease during the disease process. High blood pressure has also been related to pathological manifestations of Alzheimer's disease (senile plaques, neurofibrillary tangles, hippocampal atrophy). The exact mechanism behind these associations is not clear. Hypertension is also a risk factor for stroke, ischemic white matter lesions, silent infarcts, general atherosclerosis, myocardial infarction and cardiovascular diseases, and often clusters with other vascular risk factors, including diabetes mellitus, obesity and hypercholesterolemia. Also these risk factors have been related to Alzheimer's disease. Hypertension may thus cause cerebrovascular disease that may increase the possibility for individuals with AD encephalopathy to express a dementia syndrome. Hypertension may also lead to vessel wall changes in the brain, leading to hypoperfusion, ischemia and hypoxia which may initiate the pathological process of AD. Finally, subclinical AD may lead to increased blood pressure, and similar biological mechanisms may be involved in the pathogenesis of both disorders. Hypertension is a common disorder and often untreated. Several observational studies have reported that use of antihypertensives decreases risk of AD. Even though hypertension only results in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total number of demented individuals.
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  • Result 81-90 of 105
Type of publication
journal article (96)
research review (4)
book chapter (3)
conference paper (2)
Type of content
peer-reviewed (101)
other academic/artistic (4)
Author/Editor
Skoog, Ingmar, 1954 (59)
Waern, Margda, 1955 (28)
Östling, Svante, 195 ... (28)
Blennow, Kaj, 1958 (21)
Guo, Xinxin, 1972 (20)
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Zetterberg, Henrik, ... (13)
Lissner, Lauren, 195 ... (9)
Bengtsson, Calle, 19 ... (8)
Björkelund, Cecilia, ... (7)
Bäckman, Kristoffer, ... (7)
Minthon, Lennart (6)
Börjesson-Hanson, An ... (6)
Rosengren, Lars, 195 ... (6)
Sacuiu, Simona, 1971 (6)
Wallin, Anders, 1950 (5)
Landgren, Sara, 1980 (5)
Sigström, Robert, 19 ... (5)
Sjögren, Magnus (5)
Gudmundsson, Pia, 19 ... (5)
Nilsson, Staffan, 19 ... (4)
Zetterberg, Madelein ... (4)
von Otter, Malin, 19 ... (4)
Bogdanovic, Nenad (4)
Karlsson, Björn (4)
Andreasen, Niels (4)
Arnoldussen, I. A. C ... (4)
Kiliaan, A. J. (4)
Pantoni, Leonardo (4)
Simoni, Michela (4)
Janson, Per-Olof, 19 ... (3)
Palmer, Mona Seibt (3)
Sevlever, G. (3)
Eriksson, Elias, 195 ... (3)
Albani, D (3)
Ongaro, F (3)
Antuono, P (3)
Caberlotto, L (3)
Zanardo, A (3)
Siculi, M (3)
Gallucci, M (3)
Stener-Victorin, Eli ... (3)
Thorvaldsson, Valgei ... (3)
Joas, Erik, 1983 (3)
Zandi, Peter P (3)
Johansson, Boo (3)
Mielke, Michelle M (3)
Scarmeas, N. (3)
Olesen, Pernille J (3)
Guinjoan, S. (3)
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University
Karolinska Institutet (14)
Lund University (7)
Chalmers University of Technology (4)
Stockholm University (2)
Linköping University (2)
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University of Skövde (2)
Umeå University (1)
Jönköping University (1)
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Language
English (105)
Research subject (UKÄ/SCB)
Medical and Health Sciences (97)
Social Sciences (4)
Natural sciences (1)
Engineering and Technology (1)
Agricultural Sciences (1)

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