| 1. |
- Auer, Tibor, et al.
(författare)
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SÚLYOS KOPONYA-AGY SÉRÜLÉS VIZSGÁLATADIFFÚZIÓS TENZOR ÉS FUNKCIONÁLISMR-KÉPALKOTÁSSAL ALACSONY TÉRERÔN : [Diffusion tensor and functional MR imaging of severe traumatic craniocerebral injury at low magnetic field]
- 2007
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Ingår i: Iddegyogyaszati Szemle : Clinical Neuroscience. - : Literatura Medica Kiado. - 0019-1442 .- 2498-6208. ; 60:11-12, s. 480-488
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Tidskriftsartikel (refereegranskat)abstract
- Aim of the study: Presentation of diffusion tensor imaging (DTI) performed at low magnetic field (1 Tesla) in the algorithm of work-up of a patient suffering from severe traumatic brain injury (TBI).Method: DTI and functional MRI (fMRI) were applied at 1 Tesla for visualization of neural pathways and examination of sensory functions of a patient with severe TBI. DTI-measurement was also performed on a healthy patient for comparison.Results: DTI acquired at low magnetic field yielded appropriate visualization of neural pathways. DTI confirmed the results of the clinical and fMRI examinations in the patient suffering from severe TBI.Conclusion: An optimized DTI can be useful in the examination of patients with TBI, moreover, it may also help in the establishment of diagnoses of other central nervous system diseases affecting neuronal pathways. The presented results suggest that DTI of appropriate quality can be performed at low magnetic field.
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| 2. |
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| 3. |
- Csepregi, Gyula, et al.
(författare)
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Sülyos koponya-agy sérültek ellátása Magyarországon, 2002-ben : [Management of patients with severe head injury in Hungary, in 2002]
- 2007
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Ingår i: Orvosi Hetilap. - : Akademiai Kiado Rt.. - 0030-6002 .- 1788-6120. ; 148:17, s. 771-777
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Tidskriftsartikel (refereegranskat)abstract
- In Hungary, epidemiological and clinical data regarding brain injury were rather scarce. The Hungarian Society for Neurotrauma aimed to make a nation-wide study about the number and the mortality of patients with severe head trauma, the organization of management, the diagnostics and monitoring in use, and finally about the clinical practice of management. A national survey was carried out with questionnaires asking about data of 2001, and a prospective, three-month-long data collection based on case studies was also executed in 2002. The Hungarian National Ambulance and Emergency Service centralized information gathering on rescue, and transportation. To collect data of hospital care, a network of regional coordinators and hospital communicators was developed. The responders covered 76% of the hospital neurotrauma care in the country. The number of brain trauma patients was close to 14,000 per year: 71.3% mild, 19.4% moderate, and 9.4% severe trauma. According to prospective study the mortality of those patients who were admitted as severe head injury patients was 55% and the mortality of those who got into severe condition later was 35% during the acute care. These data showed much worse outcome than those published in Western European countries and North America. In the background the authors found communication disorder between prehospital and hospital care, extreme long time spent until the patients got to the first CT-exam and to the definitive care. The implementation of Hungarian and international head trauma guidelines did not spread widely.
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| 7. |
- Jenei, Veronica, et al.
(författare)
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Az R-(-)-deprenyl szerepe neuronalis es nem neuronalis sejtek adheziojaban
- 2005
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Ingår i: Orvosi Hetilap. - 0030-6002. ; 146:13, s. 601-606
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Tidskriftsartikel (refereegranskat)abstract
- Role of R-(-)-deprenyl in adhesion of neuronal and non-neuronal cells. The beneficial effect of the anti-parkinsonian monoamine oxidase-B inhibitor, R-(-)-deprenyl has been shown in a number of different diseases, such as Parkinson's and Alzheimer's disease, atherosclerosis or tumor formation. The role of the cytoskeleton, the main component of cell adhesion, has been suggested in the development of these diseases. Nevertheless, the effect of the drug on cell adhesion has never been examined. In the present study, the authors studied the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal (PC12, rat phaeochromocytoma) and non-neuronal (NIH3T3, NIH3T3/EGFR, NIH3T3/EGFR-e3B1 mouse embryo fibroblasts, and 5180 mouse sarcoma) cells using cell association assay. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 cells, which contain no monoamine oxidase-B, and we observed the same effect in NIH3T3 cells at concentrations lower than those needed for monoamine oxidase-B inhibition. Interestingly, R-(-)-deprenyl increased cell-cell adhesion of tumor cell lines as well. The effect of R-(-)-deprenyl was not reversible during a 24-hour recovery period. At the same time, the monoamine oxidase-B inactive isomer of the drug, S-(+)-deprenyl had no effect on cell-cell adhesion in PC12 and NIH3T3 cells. In this study, the authors described a new, monoamine oxidase-B independent effect of R-(-)-deprenyl on cell-cell adhesion both in neuronal and non neuronal cells. The authors' results with S-(+)-deprenyl suggest that the sterical structure of the drug is an important factor of the observed effect, which is probably a consequence of an irreversible change in the cells.
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| 8. |
- Károly, Csaba, 1974-
(författare)
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Toboz és doboz. Két vitatott eredetű szavunk
- 2008
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Ingår i: A nyelvtörténeti kutatásokújabb eredményei 5. - Szeged : JATEPress. - 9789634828624 ; , s. 113-126
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Konferensbidrag (refereegranskat)
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