| 11. |
- Andersson, Frida, 1977-
(författare)
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Performing Co-production : On the logic and practice of shopping at IKEA
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Contemporary western society has often been described as a “consumer society” in relation to the producer oriented form that characterised the industrial society. While consumer habits used to be seen as a reflection of a person’s occupational status or place in a stable societal hierarchy, it has now become recognised as a practice through which people’s identity and status is partially defined by the choices they make as consumers. This has not only changed the view of the consumer but also created a new role for economic actors. Instead of merely responding to demand they have been recognised as active participants in ongoing processes of socio-cultural transformation. In this thesis I develop a particular understanding of the relation between the activities taking place within consumer markets and specific processes of home making. With theoretical reference to a performative perspective on economic markets and using my own empirical study of the multinational retailer IKEA’s operation in the North East of England, the thesis describes shopping at IKEA as a situated encounter where economic exchange becomes framed as meaningful in particular ways. At IKEA, this process is specifically organised around a principle of co-production. By doing part of the work in terms of picking up and assembling flat-packed furniture, the consumers are offered a low price. Rather than being limited to this work, co-productivity is here identified as a “calculative” logic and practice that characterises and frames the shopping experience as a whole and creates a relation between the consumer and the retailer through the medium of the retail brand. The co-productive calculation established through the shopping experience then continues to make sense as part of ongoing processes of home making. It does so in ways that enhances the immediate, temporary and mobile aspects of the home. Hence, it is by linking the experience of shopping at IKEA and processes of home making that the relation between economic exchange and the ongoing processes of socio-cultural transformation is identified. Rather than answering a particular question, the research and analysis constitutes a specific approach to how economic exchange may be understood and offers some suggestions as to what this may entail in terms of how relations within economic markets may be organised.
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| 13. |
- Andersson, Frida, et al.
(författare)
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Regionalisering och skalpolitik
- 2008
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Ingår i: Regionalpolitikens geografi. - Lund : Studentlitteratur. - 9789144015415 ; , s. 115-138
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Andersson, Irene, 1978
(författare)
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Cardiovascular effects of growth hormone. Studies in genetically engineered mice
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. Two genetically engineered mice models were used, bovine GH transgenic (bGH) and GH receptor/binding protein knock-out mice (GHR KO). In addition a third mouse model was generated through crossbreeding of bGH and an atherosclerosis prone mouse strain, apoE-/-, yielding apoE-/-/bGH mice. bGH mice had increased mean arterial BP compared to control mice as measured by telemetry. The hypertension was not salt sensitive but associated with increased resistance of the hindquarter vasculature. Mesenteric arteries from bGH mice displayed intact endothelial function and decreased sensitivity to noradrenaline, as assessed by myograph technique, while carotid artery and aorta displayed impaired endothelial function. Treatment of the vessels with a super oxide dismutase (SOD) mimetic appeared to abolish differences in endothelium dependent vasodilation between bGH and control mice. However, aorta from young bGH mice had intact endothelial function accompanied by increased mRNA levels of SOD and endothelial nitric oxide synthase, semi quantified by real-time PCR. Heart rate responses measured by telemetry, to pharmacological challenging of the sympathetic and parasympathetic nervous system, showed that bGH mice had reduced ability for sympathetic activation but intact reflex activation of parasympathetic nervous system. bGH mice also had decreased heart rate variability and reduced noradrenaline concentrations in plasma and tissue, measured by high performance liquid chromatography. Systolic BP, measured by tail-cuff technique, was increased in female apoE-/-/bGH mice compared to apoE-/- control mice. Atherosclerotic plaque area in the thoracic aorta, quantified en face after lipid staining, was significantly increased in male apoE-/-/bGH compared to control, and tended to be increased in female apoE-/-/bGH. Interestingly, female apoE-/-/bGH had a more atherogenic serum lipid profile than male. Finally, GHR KO mice had decreased systolic BP measured by tail-cuff technique and reduced cardiac and vascular structure but intact endothelial function. Furthermore, GHR KO mice had impaired cardiac function as assessed by echocardiography. In summary, this thesis has generated new knowledge on the effects of GH on cardiovascular function and development of atherosclerosis. It has presented a novel mouse model that facilitates direct studies on the mechanism involved in GH induced atherogenesis. A further important finding is that GH appears to have profound effects on sympathetic nervous system function and tissue noradrenaline levels. This may be an interesting future target for treatment of diseases associated with autonomic dysfunction.
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| 18. |
- Andersson, Iréne, et al.
(författare)
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Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty.
- 2001
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Ingår i: Canadian journal of anaesthesia = Journal canadien d'anesthésie. - 0832-610X. ; 48:3, s. 251-5
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To determine whether salvaged autologous blood collected postoperatively contains complement split products (SC5b-9), and pro-inflammatory cytokines (IL-6 and IL-8) and whether there are any differences between blood collected during hip or knee surgery. METHODS: Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied. Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood. The salvaged blood was filtered during collection through a 200 microm filter and before infusion a 40 microm filter was used. Samples for complement and cytokine determinations were drawn from the circulation and from the collected blood. RESULTS: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvaged blood. The concentrations were higher than in the circulation (P < 0.05). The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12-18 hr after transfusion. There were no differences regarding SC5b-9, IL-6, and IL-8 in the blood collected after hip or knee surgery. CONCLUSION: Blood collected from a surgical wound contains large concentrations of inflammatory mediators. There were no differences between blood collected during hip or knee surgery.
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| 19. |
- Andersson, Irene, 1978, et al.
(författare)
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Endothelial dysfunction in growth hormone transgenic mice
- 2006
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Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 110:2, s. 217-25
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Tidskriftsartikel (refereegranskat)abstract
- Acromegaly [overproduction of GH (growth hormone)] is associated with cardiovascular disease. Transgenic mice overexpressing bGH (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice. We studied the ACh (acetylcholine)-induced relaxation response in aortic and carotid rings of young (9-11 weeks) and aged (22-24 weeks) female bGH transgenic mice and littermate control mice, without and with the addition of a free radical scavenger {MnTBAP [Mn(III)tetrakis(4-benzoic acid)porphyrin chloride]}. We also measured mRNA levels of eNOS (endothelial nitric oxide synthase) and EC-SOD (extracellular superoxide dismutase). Intracellular superoxide anion production in the vascular wall was estimated using a dihydroethidium probe. Carotid arteries from bGH transgenic mice had an impaired ACh-induced relaxation response (young, 46 +/- 7% compared with 69 +/- 8%; aged, 52 +/- 5% compared with 80 +/- 3%; P < 0.05), whereas endothelial function in aorta was intact in young but impaired in aged bGH transgenic mice. Endothelial dysfunction was corrected by addition of MnTBAP in carotid arteries from young mice and in aortas from aged mice; however, MnTBAP did not correct endothelial dysfunction in carotid arteries from aged bGH transgenic mice. There was no difference in intracellular superoxide anion production between bGH transgenic mice and control mice, whereas mRNA expression of EC-SOD and eNOS was increased in aortas from young bGH transgenic mice compared with control mice (P < 0.05). We interpret these data to suggest that bGH overexpression is associated with a time- and vessel-specific deterioration in endothelial function, initially caused by increased oxidative stress and later by other alterations in vascular function.
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