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Sökning: LAR1:gu > Forskningsöversikt

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51.
  • Albrektsson, Tomas, 1945, et al. (författare)
  • Initial and long-term crestal bone responses to modern dental implants
  • 2017
  • Ingår i: Periodontology 2000. - : Wiley. - 0906-6713 .- 1600-0757. ; 73:1, s. 41-50
  • Forskningsöversikt (refereegranskat)abstract
    • Successful osseointegration is the result of a controlled foreign body reaction to dental implants. Osseointegrated implants have demonstrated excellent long-term survivability, although they may be subject to limited marginal bone loss. Marginal bone loss during the first few years after implant placement seldom represents disease, but is instead the result of an adaptive bone response to surgical trauma and implant loading. It is not uncommon for implants with early marginal bone loss to enter a long-lasting state of bone stability. Extensive bone resorption after the first year is generally due to an exacerbation of adverse body reactions caused by non-optimal implant components, adverse surgery or prosthodontics and/or compromised patient factors. Disease in the form of peri-implantitis is a late complication that affects some implants with suppuration and rapid loss of crestal bone, and is probably caused by bacterial pathogens and immunological reactions. Unfortunately, the literature is not consistent with respect to the type or magnitude of clinical implant problems, including how they are defined and diagnosed. If the peri-implantitis diagnosis is confined to cases with infection, suppuration and significant bone loss, the frequency of the disease is relatively low, which is in sharp contrast to the frequencies reported with unrealistic definitions of peri-implantitis. We suggest that when modern implants are placed by properly trained individuals, only 1–2% of implants show true peri-implantitis during follow-up periods of 10 years or more. Peri-implantitis must be separated from the initial and self-limiting marginal bone loss.
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52.
  • Albrektsson, Tomas, 1945, et al. (författare)
  • State of the art in oral implants.
  • 1991
  • Ingår i: Journal of clinical periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 18:6, s. 474-81
  • Forskningsöversikt (refereegranskat)abstract
    • Uncontrolled oral implant devices are still being widely used. The documentation of most oral implant systems is poorly backed up or not followed up for an adequate time period. Success rates are being quoted without reference to any defined success criteria. Frequently used oral implant designs such as the Core-Vent, IMZ and Calcitek hydroxyapatite coated implants are in neither case supported by any adequate clinical reports from minimally 5-years of follow-up. Other implant systems such as the ITI, some subperiosteal designs and the Tübingen implant demonstrate well-controlled and acceptable 5-year data but are not followed up in a sufficient number or have demonstrated less good results in the 10-year evaluation. The Small transosteal staple has been adequately reported for more than 10 years of follow-up, whereas the Brånemark implant is the only endosseous design that has demonstrated acceptable 15-year success rates.
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53.
  • Aldrin, Viktor, 1980 (författare)
  • Adventism
  • 2013
  • Ingår i: Nationalencyklopedin.
  • Forskningsöversikt (refereegranskat)
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54.
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55.
  • Aldrin, Viktor, 1980, et al. (författare)
  • Högskolepedagogik
  • 2014
  • Ingår i: Nationalencyklopedin. - Malmö : Nationalencyklopedin.
  • Forskningsöversikt (refereegranskat)
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56.
  • Aldrin, Viktor, 1980 (författare)
  • Sjundedags-Adventistsamfundet
  • 2013
  • Ingår i: Nationalencyklopedin. - Malmö : Nationalencyklopedin.
  • Forskningsöversikt (refereegranskat)
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57.
  • Alexandersson, Mikael, 1952 (författare)
  • Att göra skillnad…
  • 2011
  • Ingår i: Pedagogiska magasinet. ; :2
  • Forskningsöversikt (refereegranskat)
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58.
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60.
  • Alexandropoulou, I., et al. (författare)
  • Ceramides in Autoimmune Rheumatic Diseases: Existing Evidence and Therapeutic Considerations for Diet as an Anticeramide Treatment
  • 2023
  • Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 15:1
  • Forskningsöversikt (refereegranskat)abstract
    • Autoimmune rheumatic diseases (AIRDs) constitute a set of connective tissue disorders and dysfunctions with akin clinical manifestations and autoantibody responses. AIRD treatment is based on a comprehensive approach, with the primary aim being achieving and attaining disease remission, through the control of inflammation. AIRD therapies have a low target specificity, and this usually propels metabolic disturbances, dyslipidemias and increased cardiovascular risk. Ceramides are implicated in inflammation through several different pathways, many of which sometimes intersect. They serve as signaling molecules for apoptosis, altering immune response and driving endothelial dysfunction and as regulators in the production of other molecules, including sphingosine 1-phosphate (S1P) and ceramide 1-phosphate (C1P). With lipid metabolism being severely altered in AIRD pathology, several studies show that the concentration and variety of ceramides in human tissues is altered in patients with rheumatic diseases compared to controls. As a result, many in vitro and some in vivo (animal) studies research the potential use of ceramides as therapeutic targets in rheumatoid arthritis (RA), ankylosing spondylitis, systemic lupus erythematosus, fibromyalgia syndrome, primary Sjogren's syndrome, systemic sclerosis, myositis, systemic vasculitis and psoriatic arthritis. Furthermore, the majority of ceramide synthesis is diet-centric and, as a result, dietary interventions may alter ceramide concentrations in the blood and affect health. Subsequently, more recently several clinical trials evaluated the possibility of distinct dietary patterns and nutrients to act as anti-ceramide regimes in humans. With nutrition being an important component of AIRD-related complications, the present review details the evidence regarding ceramide levels in patients with AIRDs, the results of anti-ceramide treatments and discusses the possibility of using medical nutritional therapy as a complementary anti-ceramide treatment in rheumatic disease.
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