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- Trainer, P J, et al.
(författare)
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Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
- 2000
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Ingår i: The New England journal of medicine. - 0028-4793. ; 342:16, s. 1171-7
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Tidskriftsartikel (refereegranskat)abstract
- Patients with acromegaly are currently treated with surgery, radiation therapy, and drugs to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have adverse effects. Pegvisomant is a genetically engineered growth hormone-receptor antagonist that blocks the action of growth hormone.We conducted a 12-week, randomized, double-blind study of three daily doses of pegvisomant (10 mg, 15 mg, and 20 mg) and placebo, given subcutaneously, in 112 patients with acromegaly.The mean (+/-SD) serum concentration of insulin-like growth factor I (IGF-I) decreased from base line by 4.0+/-16.8 percent in the placebo group, 26.7+/-27.9 percent in the group that received 10 mg of pegvisomant per day, 50.1+/-26.7 percent in the group that received 15 mg of pegvisomant per day, and 62.5+/-21.3 percent in the group that received 20 mg of pegvisomant per day (P<0.001 for the comparison of each pegvisomant group with placebo), and the concentrations became normal in 10 percent, 54 percent, 81 percent, and 89 percent of patients, respectively (P<0.001 for each comparison with placebo). Among patients treated with 15 mg or 20 mg of pegvisomant per day, there were significant decreases in ring size, soft-tissue swelling, the degree of excessive perspiration, and fatigue. The score fortotal symptoms and signs of acromegaly decreased significantly in all groups receiving pegvisomant (P< or =0.05). The incidence of adverse effects was similar in all groups.On the basis of these preliminary results, treatment of patients who have acromegaly with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement.
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| 3. |
- Ansebo, L., et al.
(författare)
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Antennal and behavioural response of codling moth Cydia pomonella to plant volatiles
- 2004
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Ingår i: Journal of applied entomology. - : Wiley. - 0931-2048 .- 1439-0418. ; 128:7, s. 488-493
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Tidskriftsartikel (refereegranskat)abstract
- Identification of host volatile compounds attractive to codling moth Cydia pomonella, a most important insect of apple, will contribute to the development of safe control techniques. Synthetic apple volatiles in two doses were tested for antennal and behavioural activity in codling moth. Female antennae strongly responded to (Z)3-hexenol, (Z)3-hexenyl benzoate, (Z)3-hexenyl hexanoate, (+/-)-linalool and E,E-alpha-farnesene. Two other compounds eliciting a strong antennal response were the pear ester, ethyl (E,Z)-2,4-decadienoate, and its corresponding aldehyde, E,E-2,4-decadienal, which is a component of the larval defence secretion of the European apple sawfly. Attraction of codling moth to compounds eliciting a strong antennal response was tested in a wind tunnel. Male moths were best attracted to a blend of (E,E)-alpha-farnesene, (E)-beta-farnesene and ethyl (E,Z)-2,4-decadienoate. The aldehyde E,E-2,4-decadienal had an antagonistic effect when added to the above mixture.
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| 7. |
- Bengtsson, M., et al.
(författare)
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Plant odor analysis of apple : Antennal response of codling moth females to apple volatiles during phenological development
- 2001
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Ingår i: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 49:8, s. 3736-3741
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Tidskriftsartikel (refereegranskat)abstract
- Volatile compounds were collected from apple branches (Malus domestica) at different developmental stages, and the antennal response of codling moth females (Cydia pomonella) to these compounds was recorded by electroantennography coupled to gas chromatography. Presence of a range of terpenoid compounds, many of which had antennal activity, was characteristic for volatile collections from branches with leaves, and from small green apples. Nine compounds from branches with leaves and green fruit consistently elicited an antennal response: methyl salicylate, (E)-beta -farnesene, fi-caryophyllene, 4,8-dimethyl-1,3(E),7-nonatriene, (Z)3-hexenol, (Z,E)-alpha -farnesene, linalool, germacrene D, and (EE)-alpha -farnesene. The bouquet emitted from flowering branches contained in addition several benzenoid compounds which were not found after bloom. Small green apples, which are the main target of codling moth oviposition during the first seasonal flight period, released very few esters. In comparison, fully grown apples released a large number of esters, but fewer terpenoids. The study of apple volatiles eliciting an antennal response, together with a survey of the seasonal change in the release of these compounds, is the first step toward the identification of volatiles mediating host-finding and oviposition in codling moth females.
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| 8. |
- Blücher, D. Bengtsson, et al.
(författare)
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Scanning kelvin probe force microscopy - A useful tool for studying atmospheric corrosion of MgAl alloys in situ
- 2004
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Ingår i: JOURNAL OF THE ELECTROCHEMICAL SOCIETY. - : The Electrochemical Society. - 0013-4651 .- 1945-7111. ; 151:12, s. B621-B626
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Tidskriftsartikel (refereegranskat)abstract
- Scanning Kelvin probe force microscopy (SKPFM) is used to study the initial stages of atmospheric corrosion of an AlMg alloy and of physical vapor deposition (PVD) deposited 2 μm Al dots on pure Mg. The latter system is used as a model of a two-phase AlMg alloy. The influence of CO2 was studied in situ in humid air using SKPFM. This method allows for the in situ investigation of the evolution of the Volta potential during exposure, the resolution being in the submicrometer range. The temperature was 22.0°C, and the relative humidity was 85 or 95%. The concentration of CO2 was <1 or 350 ppm. The corrosion products were analyzed by gravimetry, ion chromatography, X-ray diffraction, scanning electron microscopy, scanning Kelvin probe, and Auger electron spectroscopy. We found that the initial stages of atmospheric corrosion on magnesium are influenced by the presence of cathodic PVD-deposited aluminum. A similar effect was seen in the case of AZ91D, the aluminum-rich β-phase forming the cathodic areas. The β-phase is nobler compared to the substrate because of the higher Al content. In the absence of CO2, the corrosion attack is localized in nature whereas the presence of ambient levels of CO2 results in a more general corrosion attack. The inhibitive effect of CO2 on the atmospheric corrosion of AZ91D is explained by the formation of a passivating layer of Mg5(CO3)4(OH)2⋅5H2O. In the absence of CO2, the increase in pH originating from the cathodic reaction results in the dissolution of aluminum in the passive layer. A corrosion mechanism is proposed explaining the behavior in the two environments.
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| 9. |
- Collins, A., et al.
(författare)
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Interference elimination in glutamate monitoring with chip integrated enzyme microreactors
- 2001
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Ingår i: Electroanalysis. - 1040-0397. ; 13:6, s. 425-431
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Tidskriftsartikel (refereegranskat)abstract
- On-chip enzyme reactors are often used in medical/pharmaceutical analysis due to their inherent advantages, such as high sample throughput, low reagent consumption, stability, reproducibility and low cost. The present work describes a different application of such microreactors, namely, elimination of interfering ascorbate signals in glutamate monitoring using ascorbate oxidase modified silicon chip microreactors of different sizes (5.3 and 0.95 muL). Glutamate was monitored with a previously developed redox hydrogel integrated bienzyme electrode, based on coupled glutamate oxidase and horseradish peroxidase, inserted in a miniaturized flow cell operated at -50 mV (vs. Ag/AgCl). The developed on-line analysis system was characterized with regard to dilution effects, detection limit, response time and interference ability using model solutions and real samples. Off-line in vivo glutamate measurements could be made by injecting rat brain microdialysate samples collected before and after KCl stimulation without any interference of ascorbate, I Within the studied flow rate range (2-25 muL/min), 1 mM and 200 muM ascorbate could he totally eliminated using the larger and the mailer microreactor, respectively.
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| 10. |
- Coracini, M., et al.
(författare)
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Attraction of codling moth males to apple volatiles
- 2004
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Ingår i: Entomologia Experimentalis et Applicata. - : Wiley. - 0013-8703 .- 1570-7458. ; 110:1, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- The attraction of the codling moth, Cydia pomonella, to apple volatile compounds known to elicit an antennal response was tested both in the field and in a wind tunnel. In the field, (E)-beta-farnesene captured male moths. The addition of other apple volatiles, including (E,E)-alpha-farnesene, linalool, or (E,E)-farnesol to (E)-beta-farnesene did not significantly augment trap catch. Few females were caught in traps which also caught male moths, but female captures were not significantly different from blank traps. In the wind tunnel, males were attracted to (E,E)-farnesol, but not to (E)-beta-farnesene. The addition of (E,E)-alpha-farnesene to (E)-beta-farnesene had a synergistic effect on male attraction. The male behavioural sequence elicited by plant volatiles, including upwind flight behaviour, was indistinguishable from the behaviour elicited by sex pheromone.
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