| 1991. |
- Gustafsson, Kristin, et al.
(författare)
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Socioeconomic status of patients in a Swedish national self-management program for osteoarthritis compared with the general population-a descriptive observational study
- 2020
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Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background First-line treatment for hip and knee osteoarthritis (OA) including education and supervised exercises, delivered as a self-management program, is considered one of the mainstays in OA treatment. However, the socioeconomic profile of the population that utilizes first-line treatment for hip and knee OA is unclear. The aim of this study was to describe the socioeconomic status (SES) of a population referred to a self-management program for OA, in comparison with that of the general Swedish population. Methods This is a cross-sectional study including 72,069 patients with hip or knee OA enrolled in the National Quality Register for Better management of patients with Osteoarthritis (BOA) between 2008 and 2016, and registered before participation in a structured OA self-management program. A reference cohort (n = 216,207) was selected from the general Swedish population by one-to-three matching by year of birth, sex and residence. Residential municipality, country of birth, marital status, family type, educational level, employment, occupation, disposable income and sick leave were analyzed. Results The BOA population had higher educational level than the reference group, both regarding patients with hip OA (77.5% vs 70% with >= 10 years of education), and with knee OA (77% vs 72% with >= 10 years of education). Their average disposable income was higher (median [IQR] in Euro (euro), for hip euro17,442 [10,478] vs euro15,998 [10,659], for knee euro17,794 [10,574] vs euro16,578 [11,221]). Of those who worked, 46% of patients with hip OA and 45% of the reference group had a blue-collar occupation. The corresponding numbers for knee OA were 51 and 44% respectively. Sick leave was higher among those with hip and knee OA (26%) than those in the reference groups (13% vs 12%). Conclusions The consistently higher SES in the BOA population compared with the general population indicates that this self-management program for OA may not reach the more socioeconomically disadvantaged groups, who are often those with a higher disease burden.
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| 1992. |
- Gustafsson, Kristin, 1976-, et al.
(författare)
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Study protocol for an observational register-based study on health and risk factors in patients with hip and knee osteoarthritis
- 2018
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 8:10
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identification of individuals with slow disease development and a good prognosis, and those that should be recommended for future joint replacement surgery. Methods and analysis This nationwide register-based study will use data for approximately 75 000 patients who sought and received core treatment for osteoarthritis in primary healthcare, and were registered in the Swedish population-based National Quality Register for Better Management of Patients with Osteoarthritis. These data will be merged with data for replacement surgery, socioeconomic factors, healthcare consumption and comorbidity from the Swedish Hip Arthroplasty Register, the Swedish Knee Arthroplasty Register, Statistics Sweden and the National Board of Health and Welfare, Sweden. The linkage will be performed using personal identity numbers that are unique to all citizens in Sweden. Ethics and dissemination The study was approved by the Regional Ethical Review Board in Gothenburg, Sweden (dnr 1059-16). The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings.
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| 1993. |
- Gustafsson, Per M., 1952, et al.
(författare)
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Association between Gm allotypes and asthma severity from childhood to young middle age.
- 2008
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Ingår i: Respiratory medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 102:2, s. 266-72
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Tidskriftsartikel (refereegranskat)abstract
- Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age. Fifty-five subjects (28 males) with childhood asthma were all followed-up prospectively on six occasions from a mean age of 9 to 35 years in a study including asthma severity scoring, spirometry, skin prick, and specific serum IgE antibody testing. At the last visit, extended lung function tests and a cold air challenge were performed, and IGHG gene polymorphisms were identified by the alternative serum IgG subclass allotypes, employing ELISA and double immunodiffusion. The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes. Among the subjects sensitized to animal danders, those with the IGHG*bf/*bf genotype showed the highest specific IgE levels. In conclusion, IGHG gene polymorphisms were associated with the severity and outcome of childhood asthma, and with the intensity of allergic sensitization.
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| 1994. |
- Gustafsson, Peik, et al.
(författare)
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Motor function and perception in children with neuropsychiatric and conduct problems : results from a population based twin study
- 2014
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Ingår i: Journal of Neurodevelopmental Disorders. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 1866-1947 .- 1866-1955.
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Children with early symptomatic psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) have been found to have high rates of motor and/or perception difficulties. However, there have been few large-scale studies reporting on the association between Conduct Disorder (CD) and motor/perception functions. The aim of the present study was to investigate how motor function and perception relate to measures of ADHD, ASD, and CD. METHODS: Parents of 16,994 Swedish twins (ages nine and twelve years) were interviewed using the Autism-Tics, ADHD and other Comorbidities inventory (A-TAC), which has been validated as a screening instrument for early onset child psychiatric disorders and symptoms. Associations between categorical variables of scoring above previously validated cut-off values for diagnosing ADHD, ASD, and CD on the one hand and motor and/or perception problems on the other hand were analysed using cross-tabulations, and the Fisher exact test. Associations between the continuous scores for ADHD, ASD, CD, and the subdomains Concentration/Attention, Impulsiveness/Activity, Flexibility, Social Interaction and Language, and the categorical factors age and gender, on the one hand, and the dependent dichotomic variables Motor control and Perception problems, on the other hand, were analysed using binary logistic regression in general estimated equation models. RESULTS: Male gender was associated with increased risk of Motor control and/or Perception problems. Children scoring above the cut-off for ADHD, ASD, and/or CD, but not those who were 'CD positive' but 'ADHD/ASD negative', had more Motor control and/or Perception problems, compared with children who were screen-negative for all three diagnoses. In the multivariable model, CD and Impulsiveness/Activity had no positive associations with Motor control and/or Perception problems. CONCLUSIONS: CD symptoms or problems with Impulsiveness/Activity were associated with Motor control or Perception problems only in the presence of ASD symptoms and/or symptoms of inattention. Our results indicate that children with CD but without ASD or inattention do not show a deviant development of motor and perceptual functions. Therefore, all children with CD should be examined concerning motor control and perception. If problems are present, a suspicion of ADHD and/or ASD should be raised.
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| 1995. |
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| 1996. |
- Gustafsson, Susanne, et al.
(författare)
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Swedish health care professionals' view of frailty in older persons
- 2012
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Ingår i: Journal of Applied Gerontology. - : Sage Publications. - 0733-4648 .- 1552-4523. ; 31:5, s. 622-640
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Tidskriftsartikel (refereegranskat)abstract
- There is a paucity of research literature concerning frailty in older persons from the health care professionals' perspective. Consequently, the purpose of this study was to elucidate health care professionals' view of frailty in older persons. An explorative, qualitative design was selected and four focus groups comprising 21 health care professionals were conducted, audiotaped, transcribed verbatim, and analyzed. Frailty was found to consist of seven dimensions: "being bodily weak and ill," "being negatively influenced by personal qualities," "lacking balance in everyday activities," "being dependent in everyday life," "not being considered important," "being hindered by the physical milieu and defective community service," and "having an inadequate social network." The results showed that health care professionals' view of frailty in older persons differed from the current state of knowledge on frailty. This implies that the seven dimensions found to constitute frailty could contribute to a more comprehensive understanding of the concept.
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| 1997. |
- Gustafsson Sendén, Marie, et al.
(författare)
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Introducing a gender-neutral pronoun in a natural gender language: the influence of time on attitudes and behavior
- 2015
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- The implementation of gender fair language is often associated with negative reactions and hostile attacks on people who propose a change. This was also the case in Sweden in 2012 when a third gender-neutral pronoun hen was proposed as an addition to the already existing Swedish pronouns for she (hon) and he (han). The pronoun hen can be used both generically, when gender is unknown or irrelevant, and as a transgender pronoun for people who categorize themselves outside the gender dichotomy. In this article we review the process from 2012 to 2015. No other language has so far added a third gender-neutral pronoun, existing parallel with two gendered pronouns, that actually have reached the broader population of language users. This makes the situation in Sweden unique. We present data on attitudes toward hen during the past 4 years and analyze how time is associated with the attitudes in the process of introducing hen to the Swedish language. In 2012 the majority of the Swedish population was negative to the word, but already in 2014 there was a significant shift to more positive attitudes. Time was one of the strongest predictors for attitudes also when other relevant factors were controlled for. The actual use of the word also increased, although to a lesser extent than the attitudes shifted. We conclude that new words challenging the binary gender system evoke hostile and negative reactions, but also that attitudes can normalize rather quickly. We see this finding very positive and hope it could motivate language amendments and initiatives for gender-fair language, although the first responses may be negative.
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| 1998. |
- Gustafsson Sendén, Marie, et al.
(författare)
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Pronouns Beyond the Binary : The Change of Attitudes and Use Over Time
- 2021
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Ingår i: Gender & Society. - : SAGE Publications. - 0891-2432 .- 1552-3977. ; 35:4, s. 588-615
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Tidskriftsartikel (refereegranskat)abstract
- Gender-inclusive language, such as the Swedish pronoun hen, may aid in breaking a binary notion of gender and avoid sexism. The present study followed the implementation of a gender-inclusive third-person pronoun singular (hen) in Swedish in two surveys with representative samples in 2015 (at the time when hen was introduced in the official Swedish dictionary; N = 1212) and in 2018 (N = 2009). The surveys comprised measures of attitudes toward, and use of, hen as well as possible predictors such as area of residence, age, preferred pronoun, political orientation, and interest in gender issues. Results showed that attitudes toward hen became more positive and that use of hen increased between 2015 and 2018. About half of the population used hen in their communication in 2018, which is a 14-percentage-point increase from 2015. Younger age, she or hen as preferred pronoun, political left-wing orientation, and interest in gender issues predicted a more positive attitude and a more frequent use. Furthermore, the positive change between 2015 and 2018 was larger among younger people, indicating that hen will remain in the Swedish language. The present research is unique in that it follows a gender-fair language initiative during its implementation in representative samples, thereby providing insights for social movements aiming for gender-fair language. We also discuss the theoretical implications of a gender-inclusive pronoun in comparison with past studies on gender-fair language.
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| 1999. |
- Gustafsson Sendén, Marie, et al.
(författare)
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The (Not So) Changing Man: Dynamic Gender Stereotypes in Sweden
- 2019
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- According to Social Role Theory, gender stereotypes are dynamic constructs influenced by actual and perceived changes in what roles women and men occupy (Wood and Eagly, 2011). Sweden is ranked as one of the most egalitarian countries in the world, with a strong national equality discourse and a relatively high number of men engaging in traditionally communal roles such as parenting and domestic tasks. This would imply a perceived change toward higher communion among men. Therefore, we investigated the dynamics of gender stereotype content in Sweden with a primary interest in the male stereotype and perceptions of gender equality. In Study 1, participants (N = 323) estimated descriptive stereotype content of women and men in Sweden in the past, present, or future. They also estimated gender distribution in occupations and domestic roles for each time-point. Results showed that the female stereotype increased in agentic traits from the past to the present, whereas the male stereotype showed no change in either agentic or communal traits. Furthermore, participants estimated no change in gender stereotypes for the future, and they overestimated how often women and men occupy gender non-traditional roles at present. In Study 2, we controlled for participants' actual knowledge about role change by either describing women's increased responsibilities on the job market, or men's increased responsibility at home (or provided no description). Participants (N = 648) were randomized to the three different conditions. Overall, women were perceived to increase in agentic traits, and this change was mediated by perceptions of social role occupation. Men where not perceived to increase in communion but decreased in agency when change focused on women's increased participation in the labor market. These results indicate that role change among women also influence perceptions of the male stereotype. Altogether, the results indicate that social roles might have stronger influence on perceptions of agency than perceptions of communion, and that communion could be harder to incorporate in the male stereotype.
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| 2000. |
- Gustafsson, Tobias, et al.
(författare)
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Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity
- 2013
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 43:7, s. 1779-1788
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Tidskriftsartikel (refereegranskat)abstract
- Cholera toxin (CT) binds to GM1-ganglioside receptors present on all nucleated cells. Despite this, it is a very potent mucosal adjuvant that has a dramatic impact on immune cells, as well as nerve and epithelial cells, causing diarrhea. This fact has hampered our understanding of whether the adjuvanticity of CT is direct or indirect, as cells that bind CT may or may not be involved in its adjuvant function. The mucosal barrier is maintained by tight junctions between epithelial cells but dendritic cells (DCs) can protrude luminal dendrites. Here we investigated which cells are involved in the immune augmenting effect of CT. We explored oral immunizations with ovalbumin (OVA) and CT in bone marrow chimeric mice deficient in GM1-ganglioside in defined cellular subsets. We found that chimeric mice lacking GM1 in nonhematopoietic cells, including epithelial cells, mounted an unaltered intestinal IgA response. In contrast, chimeric mice lacking GM1-expressing hematopoietic cells in general, or specifically GM1-expressing conventional DCs (cDCs), largely failed to elicit anti-OVA adaptive immune responses. Therefore, the adjuvanticity of CT does not require epithelial activation, but is directly dependent on the binding of CT to gut cDCs via GM1-ganglioside. These results could have important implications for the generation of novel oral adjuvants.
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