| 1. |
- Ribbenstedt, Anton, et al.
(author)
-
In-plate toxicometabolomics of single zebrafish embryos
- 2020
-
In: Molecular Omics. - : Royal Society of Chemistry (RSC). - 2515-4184. ; 16:3, s. 185-194
-
Journal article (peer-reviewed)abstract
- Toxicometabolomic studies involving zebrafish embryos have become increasingly popular for linking apical endpoints to biochemical perturbations as part of adverse outcome pathway determination. These experiments involve pooling embryos to generate sufficient biomass for metabolomic measurement, which adds both time and cost. To address this limitation, we developed a high-throughput toxicometabolomic assay involving single zebrafish embryos. Incubation, microscopy, embryo extraction, and instrumental metabolomic analysis were all performed in the same 96-well plate, following acquisition of conventional toxicological endpoints. The total time for the assay (including testing of 6 doses/n= 12 embryos per dose plus positive and negative controls, assessing conventional endpoints, instrumental analysis, data processing and multivariate statistics) is <14 days. Metabolomic perturbations at low dose were linked statistically to those observed at high dose and in the presence of an adverse effect, thereby contextualizing omic data amongst apical endpoints. Overall, this assay enables collection of high resolution metabolomic data in a high throughput manner, suitable for mode of action hypothesis generation in the context of pharmaceutical or toxicological screening.
|
|
| 2. |
- Kabath, Petr, et al.
(author)
-
TOI-2046b, TOI-1181b, and TOI-1516b, three new hot Jupiters from TESS: planets orbiting a young star, a subgiant, and a normal star
- 2022
-
In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 513:4, s. 5955-5972
-
Journal article (peer-reviewed)abstract
- We present the confirmation and characterization of three hot Jupiters, TOI-118 lb, TOI-1516b, and TOI-2046b, discovered by the "NESS space mission. The reported hot Jupiters have orbital periods between 1.4 and 2.05 d. The masses of the three planets are 1.18 +/- 0.14 Mj, 3.16 +/- 0.12 Mj, and 2.30 +/- 0.28 Mj, for TOI-1181b, TOI-1516b, and TOI-2046b, respectively. The stellar host of TOI-1181b is a F9IV star, whereas TOI-1516b and TOI-2046b orbit F main sequence host stars. The ages of the first two systems are in the range of 2-5 Gyrs. However, TOI-2046 is among the few youngest known planetary systems hosting a hot Jupiter, with an age estimate of 100-400 Myrs. The main instruments used for the radial velocity follow-up of these three planets are located at OndIejov, Tautenburg, and McDonald Observatory, and all three are mounted on 2-3 m aperture telescopes, demonstrating that mid-aperture telescope networks can play a substantial role in the follow-up of gas giants discovered by TESS and in the future by PLATO.
|
|
| 3. |
- Rey, J., et al.
(author)
-
Brown dwarf companion with a period of 4.6 yr interacting with the hot Jupiter CoRoT-20b
- 2018
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 619
-
Journal article (peer-reviewed)abstract
- We report the discovery of an additional substellar companion in the CoRoT-20 system based on six years of HARPS and SOPHIE radial velocity follow-up. CoRoT-20 c has a minimum mass of 17 ± 1 MJup and orbits the host star in 4.59 ± 0.05 yr, with an orbital eccentricity of 0.60 ± 0.03. This is the first identified system with an eccentric hot Jupiter and an eccentric massive companion. The discovery of the latter might be an indication of the migration mechanism of the hot Jupiter, via the Lidov-Kozai effect. We explore the parameter space to determine which configurations would trigger this type of interactions.
|
|
