| 41. |
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| 42. |
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| 43. |
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| 44. |
- Carlberg, Björn, 1983, et al.
(författare)
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Direct Photolithographic Patterning of Electrospun Films for Defined Nanofibrillar Microarchitectures
- 2010
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 26:4, s. 2235-2239
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Tidskriftsartikel (refereegranskat)abstract
- In this letter, a method of generating spatially defined electrospun microarchitectures by direct photolithographic patterning of electrospun Films is described, A photoinitiator, benzoin methyl ether, is incorporated into a solid thermoplastic electrospun polyurethane matrix selectively photo-cross-linked by standard photolithographic methods. Subsequent development in in organic solvent yields spatially defined electrospun microstructures oil a single substrate. Utilizing a multilayer approach, the method allows for the assembly of complex hierarchical electrospun structures on single substrates using methods analogous to the conventional microfabrication of solid-state devices.
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| 45. |
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| 46. |
- Carlberg, Björn, 1983, et al.
(författare)
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Electrospun polyurethane scaffolds for proliferation and neuronal differentiation of human embryonic stem cells.
- 2009
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Ingår i: Biomedical materials (Bristol, England). - : IOP Publishing. - 1748-605X .- 1748-6041. ; 4:4
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Tidskriftsartikel (refereegranskat)abstract
- Adult central nervous system (CNS) tissue has a limited capacity to recover after trauma or disease. Hence, tissue engineering scaffolds intended for CNS repair and rehabilitation have been subject to intense research effort. Electrospun porous scaffolds, mimicking the natural three-dimensional environment of the in vivo extracellular matrix (ECM) and providing physical support, have been identified as promising candidates for CNS tissue engineering. The present study demonstrates in vitro culturing and neuronal differentiation of human embryonic stem cells (hESCs) on electrospun fibrous polyurethane scaffolds. Electrospun scaffolds composed of biocompatible polyurethane resin (Desmopan 9370A, Bayer MaterialScience AG) were prepared with a vertical electrospinning setup. Resulting scaffolds, with a thickness of approximately 150 microm, exhibited high porosity (84%) and a bimodal pore size distribution with peaks at 5-6 and 1 microm. The mean fiber diameter was measured to approximately 360 nm with a standard deviation of 80 nm. The undifferentiated hESC line SA002 (Cellartis AB, Göteborg, Sweden) was seeded and cultured on the produced scaffolds and allowed propagation and then differentiation for up to 47 days. Cultivation of hESC on electrospun fibrous scaffolds proved successful and neuronal differentiation was observed via standard immunocytochemistry. The results indicate that predominantly dopaminergic tyrosine hydroxylase (TH) positive neurons are derived in co-culture with fibrous scaffolds, in comparison to reference cultures under the same differentiation conditions displaying large proportions of GFAP positive cell types. Scanning electron micrographs confirm neurite outgrowth and connection to adjacent cells, as well as cell attachment to individual fibers of the fibrous scaffold. Consequently, electrospun polyurethane scaffolds have been proven feasible as a substrate for hESC propagation and neuronal differentiation. The physical interaction between cells and the fibrous scaffold indicates that these scaffolds provide a three-dimensional physical structure; a potential candidate for neural tissue engineering repair and rehabilitation.
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| 47. |
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| 48. |
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| 49. |
- Carlberg, Björn, 1983, et al.
(författare)
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Polymer-metal nanofibrous composite for thermal management of microsystems
- 2012
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Ingår i: Materials Letters. - : Elsevier BV. - 1873-4979 .- 0167-577X. ; 75, s. 229-232
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Tidskriftsartikel (refereegranskat)abstract
- In this letter, a composite structure based on a porous electrospun polyimide structure infiltrated with indium aimed at thermal interface material applications is presented. A porous nanofibrous structure was prepared by electrospinning of polyimide. An interfacial nanocomposite layer of silver nanoparticles partially or fully embedded in the polyimide matrix was synthesized on the fiber surfaces, followed by autocatalytic deposition of a uniform silver coating (using the interfacial layer as an anchored seed layer) serving as a reactive wetting layer for the infiltrating melt. The thermal performance of the composite was evaluated and the thermal conductivity was determined to be 27 W/mK, accompanied by low contact resistance of the metallurgical bond (
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| 50. |
- Carlberg, Björn, 1983, et al.
(författare)
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Polymer nanofiber based continuous metal phase composite for thermal management applications
- 2010
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Ingår i: 3rd Electronics System Integration Technology Conference, ESTC 2010; Berlin; Germany; 13 September 2010 through 16 September 2010. - 9781424485536 ; , s. Art. no. 5642950-
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Konferensbidrag (refereegranskat)abstract
- A new composite design approach for thermal interface materials is presented. A porous electro spun nanofiber network composed of temperature stable poly imide was infiltrated with liquid phase indium at a pressure of 30 MPa. The polymer phase defmes composition and geometry, while the continuous metal phase gives binding to surfaces and high thermal conductivity. The composite was characterized by assembly of tri-layer copper/TIM/copper sandwich structures and subsequent xenon flash measurements extracting the thermal properties of the intermediate TIM layer. The interfacial contact resistance was found to be 8 Kmm2/W and the thermal conductivity was 28 W/mK, indicating the potential for use in thermal management applications.
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