| 601. |
- Granvik, Madeleine, et al.
(författare)
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The approach of Swedish municipalities to the preservation of agricultural land in a planning context
- 2015
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Ingår i: International Journal of Agricultural Resources, Governance and Ecology. - 1462-4605 .- 1741-5004. ; 11, s. 190-204
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Tidskriftsartikel (refereegranskat)abstract
- Agricultural land is one of the primary natural resources for human life. Climate change, peak oil, peak soil and a growing world population are factors that are likely to increase the importance of land in relation to both food production and the cultivation of energy crops. The current legal protection for agricultural land in Sweden is considered weak. The aim of this paper is to present the ‘state of art' in respect of how Swedish municipalities approach the issue of preserving agricultural land. The topic is analysed in the context of municipal spatial planning, through which policies, strategies and motives pertaining to the preservation of agricultural land are asserted. Results from three empirical studies show that a relatively high degree of the responding municipalities stated an interest in the preservation of agricultural land. However, their actual planning practice did not confirm such an approach.
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| 602. |
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| 603. |
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| 604. |
- Hagström, Emil, et al.
(författare)
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Parathyroid hormone and calcium are independently associated with subclinical vascular disease in a community-based cohort
- 2015
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 238:2, s. 420-426
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:Diseases with abnormal levels of parathyroid hormone (PTH) and calcium, such as primary and secondary hyperparathyroidism, are associated with an increased risk of cardiovascular morbidity and mortality. However, there is paucity on the association between calcium, PTH and abnormalities in the vascular system in the general population.METHODS:In the PIVUS study (Prospective Investigation of the Vasculature in Uppsala Seniors), a community based cohort of 70-year old men and women (n = 1016), the associations between s-calcium, p-PTH and endothelial function, arterial stiffness and blood pressures were investigated, adjusting for cardiovascular risk factors and mineral metabolism.RESULTS:In multivariable linear regression models 1 SD increase in calcium was associated with 1.1 units decrease in the stroke volume/pulse pressure ratio and 0.06 decrease in common carotid artery distensibility (p < 0.001) indicative of increased arterial stiffness. Further, calcium was associated with increasing calculated central pulse pressure with 1.3 mmHg elevation per 1 SD increase in calcium (p < 0.05). 1 SD increase in PTH was associated with 1.9 and 1.0 mmHg increase in intra-arterially measured brachial artery systolic and diastolic blood pressures, respectively (p < 0.01), as well as 1.6 and 0.9 mmHg increase in calculated central systolic and diastolic blood pressures (p < 0.05). PTH was not associated with arterial stiffness, endothelial function or pulse pressure.CONCLUSION:In a large community-based sample of elderly, calcium was independently associated with increased arterial stiffness, and PTH independently to intra-arterial peripheral and calculated central blood pressures. The findings indicate a possible link between the vasculature and mineral metabolism.
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| 605. |
- Haines, Ryan W, et al.
(författare)
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Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness
- 2023
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Ingår i: American Society of Nephrology. Clinical Journal. - : Ovid Technologies (Wolters Kluwer Health). - 1555-9041 .- 1555-905X. ; 18:8, s. 997-1005
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Tidskriftsartikel (refereegranskat)abstract
- Background: Incomplete recovery of kidney function is an important adverse outcome in survivors of critical illness. However, unlike eGFR creatinine, eGFR cystatin C is not confounded by muscle loss and may improve identification of persistent kidney dysfunction.Methods: To assess kidney function during prolonged critical illness we enrolled 38 mechanically ventilated patients with expected length of stay of >72h near admission to ICU in a single academic medical center. We assessed sequential kidney function using creatinine, cystatin C, and iohexol clearance measurements. The primary outcome was difference between eGFR creatinine and eGFR cystatin C at ICU discharge using Bayesian regression modelling. We simultaneously measured muscle mass by ultrasound of rectus femoris to assess the confounding effect on serum creatinine generation.Results: Longer length of ICU stay was associated with greater difference between eGFR creatinine and eGFR cystatin C at a predicted rate of 2 ml/min/1.73m2/day (95% confidence interval 1-2). By ICU discharge the posterior mean difference between creatinine and cystatin C eGFR was 33 ml/min/1.73m2 (95% credible interval 24-42). In 27 patients with iohexol clearance measured close to ICU discharge, eGFR creatinine was on average 2-fold greater than the iohexol gold-standard, posterior mean difference 59 ml/min/1.73m2 (95% credible interval 49-69). The posterior mean for eGFR cystatin C suggested a 22 ml/min/1.73m2 (95% credible interval 13-31) overestimation of measured GFR. Each day in ICU resulted in a predicted 2% (95%CI 1-3%) decrease in muscle area. Change in creatinine-to-cystatin C ratio showed good longitudinal, repeated measures correlation with muscle loss, R=0.61 (95% confidence interval, 0.50-0.72).Conclusions: eGFR creatinine systematically over-estimated kidney function after prolonged critical illness. Cystatin C better estimated true kidney function as it appeared unaffected by the muscle loss of prolonged critical illness.
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| 606. |
- Hallberg, Pär, et al.
(författare)
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Cystatin C vs creatinine as markers of renal function in patients on digoxin treatment
- 2004
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Ingår i: Upsala Journal of Medical Sciences. - 0300-9734 .- 2000-1967. ; 109:3, s. 247-253
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BACKGROUND: The kidney function is a major determinant of the serum concentration of digoxin as this drug is mainly eliminated unchanged through the kidneys. Since digoxin is widely prescribed among the elderly, and the glomerular filtration rate (GFR) declines with age, it is important that the clinician takes the patient's GFR into account when prescribing digoxin. Serum cystatin C has been suggested to be superior to creatinine for estimation of GFR, which may have relevance for the optimization of treatment with digoxin. METHODS: To evaluate which of the two GFR markers serum creatinine and serum cystatin C that best correlates with serum digoxin, we compared the serum levels of digoxin with the serum levels of creatinine and cystatin C in 149 patients on therapeutic drug monitoring of digoxin at our hospital. RESULTS: Overall, there was a stronger correlation between serum digoxin concentrations and cystatin C (p=0.00001) as compared to creatinine (p= 0.00003). Interestingly, of the patients with a serum digoxin concentration > or = 1.5 nmol/L, 29% had a serum creatinine level within normal limits, as compared to 20% with normal cystatin C levels. CONCLUSIONS: In this study, serum cystatin C correlated better to serum digoxin than did serum creatinine. With improved GFR monitoring, digoxin concentrations should be better controlled.
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| 607. |
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| 608. |
- Hansson, Lars-Olof, et al.
(författare)
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Comparison between Chicken and Rabbit Antibody Based Particle Enhanced Cystatin C Reagents for Immunoturbidimetry
- 2008
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Ingår i: Journal of immunoassay & immunochemistry. - : Informa UK Limited. - 1532-1819 .- 1532-4230. ; 29:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- We have compared three commercial particle enhanced cystatin C reagents. One of the reagents utilizes chicken antibodies and the other two reagents are rabbit antibody based. We show that the chicken antibody based reagent yields a higher delta absorbance when reacting with the antigen. IgY coupled to latex particles show a strong scatter response even at high antigen concentrations in contrast to the steep decline in scatter previously reported for IgY antibodies in solution. The reagent also showed a low CV for duplicate samples. Laying hens thus seems as an interesting source of antibodies for particle-enhanced immunoassays.
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| 609. |
- Hansson, Lars-Olof, et al.
(författare)
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Dagens svenska metoder för att mäta njurfunktion måste bli bättre : Rutinformlerna ger osäker diagnostik - stor risk för feldosering av läkemedel
- 2008
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 105:10, s. 731-734
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Tidskriftsartikel (refereegranskat)abstract
- Njurfunktionsmätningar och främst måttet på glomerulär filtrationshastighet (GFR) tillhör våra mest använda laboratorieanalyser.Nuvarande metoder och ekvationer för beräkning av glomerulär filtration håller för låg diagnostisk kvalitet och innebär klara risker för felklassificering av njurpatienter och feldosering av läkemedel.Nuvarande svenska metoder för att mäta GFR måste förbättras.Vi måste förbättra kunskapen om skillnader mellan GFR beräknat i ml/min och i ml/min/ 1,73 m2.Det är viktigt att vi i sjukvården har ett enhetligt sätt att rapportera beräknat GFR.
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| 610. |
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