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- Risberg, Anitha, et al.
(författare)
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Relationship between urinary albumin and albumin/creatinine ratio during normal pregnancy and pre-eclampsia.
- 2004
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Ingår i: Scand J Clin Lab Invest. - : Informa UK Limited. - 0036-5513 .- 1502-7686. ; 64:1, s. 17-23
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Risberg A, Larsson A, Olsson K, Lyrenäs S, Sjöquist M.Department of Nursing and Health Sciences, Mid Sweden University, Ornsköldsvik, Sweden. anitha.risberg@mh.sePre-eclampsia is a serious complication of pregnancy and it is important to detect the condition as early as possible. Albuminuria is an important symptom of pre-eclampsia and repeated urine analyses to screen for the condition are part of the standard antenatal care. The purpose of this study was to investigate whether measurement of the urine albumin/creatinine ratio in spot samples could be a complement to the dipstick method and could reduce the need for 24-h urine collections. Urine samples were collected for 24 h in weeks 12, 24 and 36 of pregnancy from both normotensive women and women who developed hypertension or who had pregnancy-induced hypertension (PIH) when they entered the study. The 24-h albumin excretion was significantly correlated to the albumin/creatinine ratio in all measurements (Pearson correlation coefficient). In week 12, the values were: n = 44, r = 0.964, p < 0.001 (normotensive group) and in the PIH group: n = 8, r = 0.789, p < 0.05. In week 24, the correlation values were r = 1.0 and p < 0.001 in both the normotensive group (n = 41) and in the PIH group (n = 11). In week 36 the correlation values were r = 0.791 and p < 0.001 in the normotensive group (n = 39) and r = 1.0 and p < 0.001 in the PIH group (n = 16). Microalbuminuria was defined as urine albumin excretion higher than 30 mg/24 h and this corresponded to an albumin/creatinine ratio of 2.9. Microalbuminuria was found in three persons in the PIH group and in two persons in the normotensive group. Overt albuminuria (> 300 mg/24 h) was found in one of the 46 normotensive women (2%) and in 3 of the 19 PIH women (16%). In all these women the high albumin values had been detected by using the albumin/creatinine ratio method. In conclusion, it has been found that the albumin excretion in urine correlates significantly to the albumin/creatinine ratio during pregnancy. The urinary albumin/creatinine ratio appears to be a good alternative to the dipstick method and to 24-h urine collections.PMID: 15025425 [PubMed - indexed for MEDLINE]
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- Vogel, Nina, et al.
(författare)
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Implementering av bilfria distrikt – en dokumentstudie från ett internationellt, nationellt, regionalt och lokalt perspektiv
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten består av en policy-analys gällande internationella, nationella, regionala och lokala (Malmö och Göteborg) policys som berör bilfria urbana distrikt eller implementering av sådana områden. Detta arbete är en del av projektet ”Bilfria urbana distrikt”, som är ett gemensamt forskningsprojekt mellan Lunds universitet, Sveriges landsbruksuniversitet (SLU) och Chalmers i Göteborg. Dokumenten som analyserats i denna studie kommer både från internationella aktörer, såsom Europeiska Uniounen, och nationella svenska aktörer som Boverket eller Trafikverket. Regionalt och lokalt begränsas analysen till Västra Götalandsregionen och Region Skåne, samt dokument från Malmö stad och Götegorgs stad. I analysen har det framkommit att det finns många aktörer och policys som påverkar implementeringen av bilfria urbana distrikt, vilka kan inverka såväl positivt som negativt på den vidare utvecklingen inom detta område. Dessutom visar denna studie att implementering av bilfria urban distrikt är ett mycket komplext ämne för kommunerna att hantera. För att lyckas med implementeringen behövs ett interdisciplinärt angreppssätt som involverar stads- och trafikplanerare, men även medborgare, politiker och näringsidkare. Faktorer som påverkar en lyckad implementering kan vara just att hela processen förankras i ett större sammanhang, det vill säga bland exempelvis boende, näringsidkare och politiker.
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| 10. |
- Helmersson-Karlqvist, Johanna, et al.
(författare)
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Cytokine mediated inflammation is involved in the early stages of kidney damage and dysfunction
- 2011
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Ingår i: XIII Svenska Kardiovaskulära vårmötet. - Örebro.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: Patients with severe chronic kidney disease (CKD) are characterized by increased inflammatory activity and higher oxidative stress, conditions that have been suggested to mediate the substantially increased risk for cardiovascular disease (CVD) in these patients. However, also individuals with mild signs of kidney damage and dysfunction have been shown to have an increased risk for CVD. Yet, data on the association between mild signs of kidney damage and dysfunction and markers of inflammation and oxidative stress in the community is scarce. Research Design and Methods: Accordingly, we investigated the cross-sectional associations between cystatin C based glomerular filtration rate (GFR), urinary albumin creatinine ratio (ACR), and markers of cytokine mediated inflammation (interleukin 6 [IL-6], high sensitivity C reactive protein [hsCRP], serum amyloid A [SAA]), cyclooxygenas-mediated inflammation (urinary prostaglandin F2-alpha [PGF2alpha]) and oxidative stress (urinary F2-isprostanes) in a sub-sample of a community based cohort (Uppsala Longitudinal Study of Adult Men, ULSAM, n=648, mean age 77 year) with normal eGFR (>60 ml/min/1.73m2 ) and normal ACR (<30 µmol/L) Results: In multivariable linear regression models adjusting for age, BMI, smoking, systolic and diastolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides and treatment with statin, ACE-inhibit-, ASA-, anti inflammation- , cortisone medication, eGFR was inversely associated with lower hsCRP (p<0.008), lower IL-6 (p<0.01), and ACR was positive associated with higher hsCRP (p=0.01), higher IL-6 (p=<0.004) and higher SAA (p=0.001). No significant association was seen between PGF2alpha, F2-isoprostanes and eGFR and ACR. Conclusion: Our community based data suggest that cytokine mediated inflammation is involved in the early stages of kidney damage and dysfunction, while cyclooxygenas-mediated inflammation and oxidative stress is not. Further studies are needed in order to evaluate to what extent cytokine mediated inflammation mediates the increased CVD risk seen in individuals with mild signs of kidney damage and dysfunction.
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