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Sökning: LAR1:lu > Andersson Engels Stefan

  • Resultat 61-70 av 298
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61.
  • Axelsson, Johan, et al. (författare)
  • Prior information in fluorescence molecular tomography based on multispectral fluorescence emission
  • 2007
  • Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE. - 1042-4687 .- 1605-7422. - 9780819465474 ; 6434, s. 4340-4340
  • Konferensbidrag (refereegranskat)abstract
    • Fluorescence molecular tomography (FMT) suffers from inherent ill-posedness due to the vast number of possible solutions to the reconstruction problem. To increase the robustness of such a problem one need prior information. We present here a method for rendering a priori information of the position of a fluorescent inclusion inside turbid media. The method utilizes solely two spectral bands within the fluorescence spectrum emitted from the fluorophore. The method is presented and verified using experimental data from a tissue phantom. The confinement is also used to impose weights onto the voxels before the inversion of the linear set of equations describing the FMT problem.
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62.
  • Axelsson, Johan, et al. (författare)
  • Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography
  • 2007
  • Ingår i: Optics Express. - 1094-4087. ; 15:21, s. 13574-13584
  • Tidskriftsartikel (refereegranskat)abstract
    • Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.
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63.
  • Bansal, Akshaya, et al. (författare)
  • Quasi-Continuous Wave Near-Infrared Excitation of Upconversion Nanoparticles for Optogenetic Manipulation of C. elegans
  • 2016
  • Ingår i: Small. - : Wiley. - 1613-6810 .- 1613-6829. ; 12:13, s. 1732-1743
  • Tidskriftsartikel (refereegranskat)abstract
    • Optogenetics is an emerging powerful tool to investigate workings of the nervous system. However, the use of low tissue penetrating visible light limits its therapeutic potential. Employing deep penetrating near-infrared (NIR) light for optogenetics would be beneficial but it cannot be used directly. This issue can be tackled with upconversion nanoparticles (UCNs) acting as nanotransducers emitting at shorter wavelengths extending to the UV range upon NIR light excitation. Although attractive, implementation of such NIR-optogenetics is hindered by the low UCN emission intensity that necessitates high NIR excitation intensities, resulting in overheating issues. A novel quasi-continuous wave (quasi-CW) excitation approach is developed that significantly enhances multiphoton emissions from UCNs, and for the first time NIR light-triggered optogenetic manipulations are implemented in vitro and in C. elegans. The approach developed here enables the activation of channelrhodopsin-2 with a significantly lower excitation power and UCN concentration along with negligible phototoxicity as seen with CW excitation, paving the way for therapeutic optogenetics.
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64.
  • Bendsoe, Niels, et al. (författare)
  • Fluorescence monitoring of a topically applied liposomal temoporfin formulation and photodynamic therapy of nonpigmented skin malignancies.
  • 2007
  • Ingår i: Journal of Environmental Pathology and Toxicology. - 2162-6537. ; 26:2, s. 117-126
  • Tidskriftsartikel (refereegranskat)abstract
    • Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (INN: Temoporfin) is a potent photodynamically active substance in clinical use today. Usually, the substance is given systemically and a known drawback with this administration route is a prolonged skin light sensitization. For the first time to our knowledge, a liposomal Temoporfin gel formulation for topical application was studied in connection with photodynamic therapy (PDT) of nonpigmented skin malignancies in humans. Intervals of 4 hr between drug administration and light irradiation were used. Sensitizer distribution within tumor and surrounding normal skin was investigated by means of point monitoring and imaging fluorescence spectroscopy before, during, and after PDT, showing high tumor selectivity. Furthermore, the bleaching of Temoporfin was studied during the PDT procedure by monitoring the fluorescence following excitation by using a therapeutic light. A 30−35% light-induced photometabolization was shown. No pain occurred during or after treatment. It was also observed that the treated area did not show any swollen tissue or reddening, as is often seen in PDT using topical δ-aminolevulinic acid. On controlling the patients one week after treatment, healing progress was observed in several patients and no complications were registered.
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65.
  • Bengtsson, Alexander, et al. (författare)
  • Characterization and modeling of acousto-optic signal strengths in highly scattering media
  • 2019
  • Ingår i: Biomedical Optics Express. - 2156-7085. ; 10:11, s. 5565-5584
  • Tidskriftsartikel (refereegranskat)abstract
    • Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of similar to 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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66.
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67.
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68.
  • Berg, R, et al. (författare)
  • Time-gated viewing studies on tissuelike phantoms
  • 1996
  • Ingår i: Applied Optics. - 2155-3165. ; 35:19, s. 3432-3440
  • Tidskriftsartikel (refereegranskat)abstract
    • A time-gated technique to enhance viewing through highly scattering media such as tissue is discussed. Experiments have been performed on tissue like plastic phantoms to determine the possibilities and limitations of the technique. The effects of the time-gate width and the localization, size, and optical properties of hidden objects have been studied. A computer model to simulate light propagation in tissue is also presented. The predictions of the model are compared with experimental results. (C) 1996 Optical Society ofAmerica
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69.
  • Berg, Roger, et al. (författare)
  • Time-resolved tranillumination imaging
  • 1993
  • Ingår i: Medical Optical Tomography: Functional Imaging and Monitoring. ; , s. 397-424
  • Bokkapitel (refereegranskat)
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70.
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