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Träfflista för sökning "WFRF:(James P) ;lar1:(hh)"

Search: WFRF:(James P) > Halmstad University

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  • 2019
  • Journal article (peer-reviewed)
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2.
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3.
  • Lahore, G. F., et al. (author)
  • Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases
  • 2020
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:40, s. 24986-24997
  • Journal article (peer-reviewed)abstract
    • It has proven difficult to identify the underlying genes in complex autoimmune diseases. Here, we use forward genetics to identify polymorphisms in the vitamin D receptor gene (Vdr) promoter, controlling Vdr expression and T cell activation. We isolated these polymorphisms in a congenic mouse line, allowing us to study the immunomodulatory properties of VDR in a physiological context. Congenic mice overexpressed VDR selectively in T cells, and thus did not suffer from calcemic effects. VDR overexpression resulted in an enhanced antigen-specific T cell response and more severe autoimmune phenotypes. In contrast, vitamin D3-deficiency inhibited T cell responses and protected mice from developing autoimmune arthritis. Our observations are likely translatable to humans, as Vdr is overexpressed in rheumatic joints. Genetic control of VDR availability codetermines the proinflammatory behavior of T cells, suggesting that increased presence of VDR at the site of inflammation might limit the antiinflammatory properties of its ligand.
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4.
  • Rak, Jacek, et al. (author)
  • Disciplines and measures of information resilience
  • 2017
  • In: ICTON 2017 - 19th International Conference on Transparent Optical Networks 2-6 July 2017, Girona, Catalonia, Spain. - Piscataway : IEEE. - 9781538608586
  • Conference paper (peer-reviewed)abstract
    • Communication networks have become a fundamental part of many critical infrastructures, playing an important role in information delivery in various failure scenarios triggered e.g., by forces of nature (including earthquakes, tornados, fires, etc.), technology-related disasters (for instance due to power blackout), or malicious human activities. A number of recovery schemes have been defined in the context of network resilience (with the primary focus on communication possibility in failure scenarios including access to a particular host, or information exchange between a certain pair of end nodes). However, because end-users are becoming more and more interested in information itself (regardless of its physical location in the network), it is appropriate to complement the well-defined framework of network resilience with one that addresses information resilience, and to introduce definitions of relevant disciplines and measures, as proposed in this paper. © 2017 IEEE.
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  • Result 1-4 of 4
Type of publication
journal article (3)
conference paper (1)
Type of content
peer-reviewed (4)
Author/Editor
Kelly, Daniel (1)
Sabatier, P (1)
Bengtsson-Palme, Joh ... (1)
Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
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Moore, Matthew D. (1)
Holmdahl, R (1)
Liu, Fang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Kahan, Thomas (1)
Sörelius, Karl, 1981 ... (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Backman, Lars (1)
Ohlsson, Claes, 1965 (1)
Yan, Hong (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
Zhang, Wei (1)
Hammerschmidt, Sven (1)
Patil, Chandrashekha ... (1)
Jonsson, Magnus, 196 ... (1)
Wang, Jun (1)
Pollesello, Piero (1)
Conesa, Ana (1)
El-Esawi, Mohamed A. (1)
Zhang, Weijia (1)
Nandakumar, Kutty Se ... (1)
Li, Jian (1)
Marinello, Francesco (1)
Frilander, Mikko J. (1)
Wei, Pan (1)
Badie, Christophe (1)
Zhao, Jing (1)
Li, You (1)
Bansal, Abhisheka (1)
Rahman, Proton (1)
Zubarev, R A (1)
Parchi, Piero (1)
Polz, Martin (1)
Ijzerman, Adriaan P. (1)
Subhash, Santhilal, ... (1)
Quinn, Terence J. (1)
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University
Halmstad University  (4)Undo refine
University of Gothenburg (2)
Karolinska Institutet (2)
Uppsala University (1)
Stockholm University (1)
Lund University (1)
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Chalmers University of Technology (1)
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Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Natural sciences (1)
Engineering and Technology (1)
Social Sciences (1)

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