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Träfflista för sökning "WFRF:(Johansson Kenneth) ;spr:eng"

Sökning: WFRF:(Johansson Kenneth) > Engelska

  • Resultat 1-10 av 185
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1.
  • Fretts, Amanda M., et al. (författare)
  • Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores : a meta-analysis of 50,345 Caucasians
  • 2015
  • Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 102:5, s. 1266-1278
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown. Objective: We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus. Design: Fourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined l) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations. Results: Processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-1n-pmon (95% CI: 0.035, 0.063-1n-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance. Conclusion: The association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms.
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2.
  • Ji, Xuemei, et al. (författare)
  • Protein-altering germline mutations implicate novel genes related to lung cancer development
  • 2020
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio=8.82, P=1.18x10(-15)) and replication (adjusted OR=2.93, P=2.22x10(-3)) that is more pronounced in females (adjusted OR=6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR=2.61, P=7.98x10(-22)) and replication datasets (adjusted OR=1.55, P=0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.
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5.
  • Johansson, Roger, et al. (författare)
  • Eye movements play an active role when visuospatial information is recalled from memory
  • 2012
  • Ingår i: Journal of Vision. ; 12:9
  • Konferensbidrag (refereegranskat)abstract
    • Abstract in Undetermined Whilst it has been established that spontaneous eye movements occur with visual imagery and that they are comparable with those from an original scene inspection (e.g., Brandt & Stark, 1997; Johansson, Holsanova, & Holmqvist, 2006), the exact purpose of these eye movements has been a hot topic of debate (cf., Ferreira et al., 2008; Richardson et al., 2009). Do they have an active and functional role in memory retrieval or are they merely an epiphenomenon? In a recent study we reported that when eye movements were prohibited for participants who orally described pictures from memory, their recollections became altered and impaired (Johansson, Holsanova, Dewhurst, & Holmqvist, (in press). Journal of Experimental Psychology: Human Perception and Performance). The current study was designed as a follow-up, aiming to uncover exactly how imposing different eye movements on participants affects memory retrieval processes. Eye movements were recorded from participants who recalled properties and spatial arrangements of sets of objects under four different manipulations: (1) free viewing on a blank screen; (2) gazing at a fixation cross; (3) looking at an area which was matched with the original locations of the objects to be recalled; (4) looking at an area which did not match the original locations of the objects to be recalled. By restricting eye movements in different ways during recall, we demonstrate the sensitivity of retrieval performance to specific eye movement manipulations. Results provide evidence that eye movements do have an active and supportive role when visuospatial information is recalled by highlighting the circumstances under which a visual memory is hampered. Additionally, findings suggest that the influence of "eye movements to nothing" is primarily related to the processing and retrieval of spatial information.
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6.
  • Johansson, Roger, et al. (författare)
  • Looking at the keyboard or the monitor : relationship with text production processes
  • 2010
  • Ingår i: Reading and writing. - : Springer Netherlands. - 0922-4777 .- 1573-0905. ; 23:7, s. 835-851
  • Tidskriftsartikel (refereegranskat)abstract
    • In this paper we explored text production differences in an expository text production task between writers who looked mainly at the keyboard and writers who looked mainly at the monitor. Eye-tracking technology and keystroke-logging were combined to systematically describe and define these two groups in respect of the complex interplay between text production and the reading of one's own emerging text. Findings showed that monitor gazers typed significantly faster and were more productive writers. They also read their own text more, and they frequently read in parallel with writing. Analysis of fixation durations suggests that more cognitive processing is in use during reading in parallel with writing than during reading in pauses. Keyboard gazers used the left and right cursor keys significantly more. We suggest that this is because they revised their texts in a much more serial mode than monitor gazers. Finally, analysis of the characteristics of the final texts showed no differences between the groups.
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7.
  • Johansson, Roger, et al. (författare)
  • Reading during text production
  • 2012
  • Ingår i: Learning to write effectively. - : Brill Academic Publishers. ; , s. 359-363
  • Bokkapitel (refereegranskat)
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8.
  • Johansson, Roger, et al. (författare)
  • Reading during text production
  • 2012
  • Ingår i: Current trends in European Writing Research. - Bingley, UK : Emerald. ; , s. 359-361, s. 359-361
  • Bokkapitel (refereegranskat)
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