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Träfflista för sökning "LAR1:lu ;srt2:(2005-2009)"

Sökning: LAR1:lu > (2005-2009)

  • Resultat 1-10 av 37849
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1.
  • 1973. En träff med tidsandan
  • 2008
  • Ingår i: 1973. En träff med tidsandan. - Lund : Nordic Academic Press. - 9789189116979 ; , s. 11-21
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)
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2.
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3.
  • A Smorgasbord of Cognitive Science
  • 2008
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
    • This book is intended as an introduction to the breadth of current research in cognitive science, with the research at Lund University Cognitive Science as our sample. The result is a smorgasbord for readers with some background in the neighbouring disciplines. Through the chapters we will follow some of the important cross-disciplinary issues in cognitive science. One is how the external world is represented, from cognitive maps in rats, to drawings made to enhance communication, or the organization of semantic knowledge. Another is to what extent such representations really are used: the world is often its own best model in areas from robotics to choice, and several chapters illustrate that even communication (despite its dependence on representations) is firmly situated in and constrained by its surroundings. In addition, many chapters emphasize the essentially dynamic relationship between mind and environment, in areas from development to interaction and learning. A third thread is how research concerning other animals= cognitive capacities, from pigeons to chimpanzees, has inspired research on human cognition, and how this comparative approach can be made to incorporate also non-animate fellow beings, such as robots and virtual characters. In sum, the book contains most of the areas we think are important in cognitive science today, and we hope that it will be of use for beginning researchers and advanced students in the area. Its production is part of the celebrations of Lund University Cognitive Science’s 20th anniversary. Our group hosts researchers with backgrounds in psychology, philosophy, computer science, linguistics, computational neuroscience, education, etc., and all of us have a multidisciplinary education. We encourage you to visit our web pages at www.lucs.lu.se to learn more about the activities of the group.
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4.
  • Aabenhus, Rune, et al. (författare)
  • First attempt to produce experimental Campylobacter concisus infection in mice
  • 2008
  • Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327. ; 14:45, s. 6954-6959
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: To infect mice with atypical Campylobacter concisus (C concisus) for the first time. METHODS: Three separate experiments were conducted in order to screen the ability of five clinical C concisus isolates of intestinal origin and the ATCC 33237 type strain of oral origin to colonize and produce infection in immunocompetent BALB/cA mice. The majority of the BALB/cA mice were treated with cyclophosphamide prior to C concisus inoculation to suppress immune functions. Inoculation of C concisus was performed by the gastric route. RESULTS: C concisus was isolated from the liver, ileum and jejunum of cyclophosphamide-treated mice in the first experiment. No C concisus strains were isolated in the two subsequent experiments. Mice infected with C concisus showed a significant loss of body weight from day two through to day five of infection but this decreased at the end of the first week. Histopathologicalexamination did not consistently find signs of inflammation in the gut, but occasionally microabscesses were found in the liver of infected animals. CONCLUSION: Transient colonization with C concisus was observed in mice with loss of body weight. Future studies should concentrate on the first few days after inoculation and in other strains of mice. (C) 2008 The WJG Press. All rights reserved.
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5.
  • Aaby, Peter, et al. (författare)
  • Vaccinia scars associated with better survival for adults. An observational study from Guinea-Bissau
  • 2006
  • Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:29-30, s. 5718-5718
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Live vaccines including BCG and measles may have non-targeted beneficial effects on childhood survival in areas with high mortality. The authors therefore undertook a survey of vaccinia scars to evaluate subsequent mortality. SUBJECTS: Based on a population census, a cohort of 1893 adults in urban Guinea-Bissau was examined in 1998 and followed until 2002. MAIN OUTCOME MEASURE: All cause mortality, excluding accidents. RESULTS: The median age of vaccinia vaccinations had been 16-18 years. Adults with a vaccinia scar had a mortality ratio (MR) of 0.60 (0.41-0.87) compared to those without any scar. The effect was stronger for women. Mortality decreased with each additional vaccinia scar (MR=0.73 (0.56-0.95)). Among 502 individuals with information on HIV infection, the age-adjusted HIV-2 prevalence was 2.45 (1.06-5.65) for those with a vaccinia scar. Control for district, ethnic group, schooling, place of birth, quality of housing and HIV status had little effect on the estimate. Since vaccinia and BCG scars could have been confused, mortality for adults with vaccinia and/or BCG scar was compared to those without, the MR being 0.61 (0.41-0.89). CONCLUSION: Known cultural or socio-economic factors possibly associated with access to vaccination had no influence on the mortality ratio for having a vaccinia scar. Hence, vaccinia vaccination may have a prolonged beneficial effect on adult survival.
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6.
  • Aad, G., et al. (författare)
  • The ATLAS Experiment at the CERN Large Hadron Collider
  • 2008
  • Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08003
  • Forskningsöversikt (refereegranskat)abstract
    • The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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7.
  • Aalto, Kristina, et al. (författare)
  • The Nordic swan
  • 2008
  • Rapport (övrigt vetenskapligt/konstnärligt)
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8.
  • Aaltonen, Emil (författare)
  • Prokaryotic Arsenic Resistance - Studies in Bacillus subtilis
  • 2008
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Arsenic is a toxic metalloid which is found all over the globe. Due to its toxicity and wide abundance, all living organisms have evolved intrinsic arsenic resistance systems. In this study, three proteins that provide arsenic resistance in the Gram-positive bacterium Bacillus subtilis have been investigated. Acr3 is a trans-membrane protein that extrudes arsenite to the cell exterior. It belongs to the ACR family of arsenite transporters. Experimental data on the topology of Acr3, the first ever for a member of the ACR family, is provided and show that Acr3 has 10 trans-membrane helices. Both the N- and C-terminal ends of Acr3 are located to the cytoplasm and the protein has unusually short loops connecting its helices. ArsR is an arsenite sensitive transcription regulator that controls the expression of genes encoding arsenic resistance proteins. Experiments show that the operator site for ArsR from B. subtilis consists of a 6-6-6 inverted repeat and that DNA binding by ArsR involves formation of higher order multimers of the protein. The ArsK (former YqcK) protein has an unknown function. The present study shows that the arsK gene contributes to resistance towards both arsenite and arsenate. The results indicate that the function of ArsK is important in an aerobic environment and that it decreases the inhibitory effect that arsenite has on the sporulation efficiency of B. subtilis. A function of ArsK that involves an enzymatic addition of low molecular weight thiols to arsenic is proposed.
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9.
  • Aaltonen, Emil, et al. (författare)
  • Transmembrane topology of the Acr3 family arsenite transporter from Bacillus subtilis.
  • 2008
  • Ingår i: Biochimica et Biophysica Acta - Biomembranes. - : Elsevier BV. - 0005-2736. ; 1778:4, s. 963-973
  • Tidskriftsartikel (refereegranskat)abstract
    • The transmembrane topology of the Acr3 family arsenite transporter Acr3 from Bacillus subtilis was analysed experimentally using translational fusions with alkaline phosphatase and green fluorescent protein and in silico by topology modelling. Initial topology prediction resulted in two models with 9 and 10 TM helices respectively. 32 fusion constructs were made between truncated forms of acr3 and the reporter genes at 17 different sites throughout the acr3 sequence to discriminate between these models. Nine strong reporter protein signals provided information about the majority of the locations of the cytoplasmic and extracellular loops of Acr3 and showed that both the N- and the C-termini are located in the cytoplasm. Two ambiguous data points indicated the possibility of an alternative 8 helix topology. This possibility was investigated using another 10 fusion variants, but no experimental support for the 8 TM topology was obtained. We therefore conclude that Acr3 has 10 transmembrane helices. Overall, the loops which connect the membrane spanning segments are short, with cytoplasmic loops being somewhat longer than the extracellular loops. The study provides the first ever experimentally derived structural information on a protein of the Acr3 family which constitutes one of the largest classes of arsenite transporters.
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10.
  • Aaltonen, Kirsimari, et al. (författare)
  • Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer
  • 2009
  • Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 113:1, s. 75-82
  • Tidskriftsartikel (refereegranskat)abstract
    • Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P < 0.0005), high cyclin A (P < 0.0005) and Ki67 (P < 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P < 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P < 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers.
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