| 1. |
|
|
| 2. |
- Nilsson, Sven E, et al.
(författare)
-
Långtidsöverlevnaden vid diabetes har successivt förbättrats. Lång sjukdomsduration kan ge information om protektiva möjligheter
- 2005
-
Ingår i: Läkartidningen. - 0023-7205. ; 102:28, s. 2066-2070
-
Tidskriftsartikel (refereegranskat)abstract
- Studies on patients with long-term diabetes survival without severe complications can give information about protective factors. Therefore, the present study aims to describe the long-term survival of patients with diabetes during successive periods following the introduction of insulin therapy in 1923. After registration in 1973 of the first local diabetic patient in Jonkoping with a fifty-year survival, this group has successively increased. Of those who were diagnosed during the period 1940 through 1949 there was a fifty-year survival in about one third. The successively better survival emphasises the importance of therapeutic progress. The study found no difference in diabetes control between those surviving 50 years and those with an age-matched group with a survival of 15 years. The insulin dose tended to decrease after 30 years duration. Peripheral vibration sensibility as well as renal function deteriorated by longer duration. The serum ratio of HDL-cholesterol to triglycerides increased. The frequency of glaucoma, cataract, and a history of myocardial infarction increased. In spite of long duration, one third of the sample had escaped serious retinopathy.
|
|
| 3. |
- Wex, H., et al.
(författare)
-
Connecting hygroscopic growth at high humidities to cloud activation for different particle types
- 2008
-
Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 3:3, s. 35004-
-
Tidskriftsartikel (refereegranskat)abstract
- This work recompiles studies that have been done with respect to hygroscopic growth in the regime of high relative humidities and with respect to activation for different kinds of particle at LACIS (Leipzig Aerosol Cloud Interaction Simulator) during the last few years. The particles examined consisted of a mixture of succinic acid and ammonium sulfate, seawater samples, soot coated with an organic and/or an inorganic substance, and two different atmospheric HULIS (HUmic LIke Substance) samples. An influence of changing non-ideal behavior and of slightly soluble substances on the hygroscopic growth was found in varying degrees in the subsaturation regime. The measured hygroscopic growth was extrapolated towards supersaturation, using a simple form of the Kohler equation, and assuming a constant number of molecules/ions in solution for high relative humidities (>= 95% or >= 98%, depending on the particles). When the surface tension of water was used, the modeled critical supersaturations reproduced the measured ones for the seawater samples and for the coated soot particles. To reach agreement between measured and modeled critical supersaturations for the HULIS particles, a concentration-dependent surface tension had to be used, with values of the surface tension that were lower than that of water, but larger than those that had been reported for bulk measurements in the past.
|
|
| 4. |
- Andersson, Gunnel, 1958-
(författare)
-
Urinary incontinence : prevalence, treatment seeking behaviour, experiences, and perceptions among persons with and without urinary leakage
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis is to describe urinary incontinence (UI) from a population perspective and to describe experiences and perceptions of UI from an individual perspective. This includes assessing the prevalence of urinary incontinence as well as describing treatment seeking and experiences of living with UI. A secondary aim was to describe the perception of UI among cultures other than the Swedish mainstream, exemplified in this case by Syrian women living in Sweden. Both quantitative and qualitative methods were used, including questionnaires and interviews. Studies I and II were quantitative studies based on a population-based study. Together with a postal survey on general health and living conditions “Life & Health”, a questionnaire on urinary incontinence was sent out to 15 360 randomly-selected residents aged 18-79 in Orebro County, Sweden. In Study I, UI was found to affect 19%. The majority of the respondents experienced minor problems, and only 18% of those reporting UI wanted treatment. However, there was also a group who reported severe problems, but despite this 42% of them did not want treatment. Study II investigated why people with UI refrain from seeking care and treatment. It was found that the desire for treatment was regulated by the frequency of UI, being restricted from participating in various activities, the degree of inconvenience, and the type of UI. Studies III and IV were both qualitative interview studies, describing older women’s experiences of living with UI (Study III) and Syrian women’s perceptions of UI (Study IV). There were similarities between the results of these two studies; the women described UI as a normal and expected problem, and they knew that the district nurse could prescribe incontinence protections and that treatments existed. In both studies, the women expressed difficulties in making contact with the health care service, while the women who did not speak Swedish (Study IV) also had difficulties due to different communication problems. In conclusion, it is important that health care resources are optimized to identify and meet the needs of those who experience major problems with UI, and that there is awareness of the communication difficulties that can be present in meeting with people who speak other languages. However it is also important not to medicalize those who experience minor problems and who have the desire to manage on their own.
|
|
| 5. |
|
|
| 6. |
- El-Sayed, Najib M., et al.
(författare)
-
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
- 2005
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 309:5733, s. 409-15
-
Tidskriftsartikel (refereegranskat)abstract
- Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
|
|
