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  • Resultat 276231-276240 av 547772
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276231.
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276232.
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276233.
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276234.
  • Lambrix, Patrick, Professor, 1965- (författare)
  • Aspects of version management of composite objects
  • 1992
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • An important aspect of object oriented database systems is the ability to build up composite objects from objects parts. This allows modularity in the representation of objects and reuse of parts where appropriate. It is also generally accepted that object-oriented database systems should be able to handle temporal data. However little theoretical work has been done on temporal behaviour of composite objects, amd only relatively few systems attempt to incorporate both historical information and composite objects in a multi-user environment.We argue that the support for handling temporal information provided by other systems addresses only one of two important kinds of historical information. We describe the notions of temporal history and edit history.In this work we also make a first step in formalizing historical information of composite objects. We identify different kinds of compositions and give formal synchronization rules between a composition and its components to induce the desired behavior of these compositions in a database setting. We also discuss the transitivity property for the part-of relation with respect to the newly defined compositions.Finally we address the problem of maintaining consistent historical information of a composition using the historical information of its components. This problem occurs as a result of sharing objects between ceveral compositions. We propose a solution and show an implementation in the LINCKS system.
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276235.
  • Lambrix, Patrick, et al. (författare)
  • Contributions of LiU/ADIT to Debugging Ontologies and Ontology Mappings
  • 2012
  • Ingår i: Advances in secure and networked information systems. - Linköping : Linköping University Electronic Press. - 9789175197173 - 9789175197166 ; , s. 109-120
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • This book contains contributions by current and former colleagues and PhD students of professor Nahid Shahmehri in celebration of her 60th birthday. Although it would be difficult to cover the full range of her academic contributions, we have at least been able to hint the importance and the breadth of her work. We have chosen the title ‘Advances in Secure and Networked Information Systems - The ADIT Perspective’ as many of the contributions of Nahid and her group have been in these areas, given a fairly broad interpretation of “networked information systems”. In this collection we have gathered both republications of past work as well as newly written articles.
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276236.
  • Lambrix, Patrick, et al. (författare)
  • Merging DAML+OIL Ontologies
  • 2005
  • Ingår i: Databases and Information Systems (Selected Papers from the Sixth International Baltic Conference DB&IS'2004). - Amsterdam : IOS Press. - 1586034855 ; , s. 249-258
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Ontologies arebeing used nowadays in many areas. Within eacharea there are a number of ontologies, each with their own focus,that containoverlapping information. In applications using multiple ontologiesit istherefore of interest to be able to merge these ontologies. In thispaper wedescribe a prototype implementation of SAMBO, an ontology mergetool forDAML+OIL ontologies. The tool generates suggestions for mergingconceptsand relations and for creating is-a relationships between concepts.Weevaluate different strategies for the generation of suggestions. Wealsocompare our tool with the ontology merge tools Protégé-2000 withPROMPTand Chimaera in terms of the quality of suggestions and the time ittakes tomerge ontologies using these tools.
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276237.
  • Lambrix, Patrick (författare)
  • Ontologies in Bioinformatics and Systems Biology
  • 2004. - 5
  • Ingår i: Artificial Intelligence Methods and Tools for Systems Biology. - Dordrecht : Springer Science+Business Media B.V.. - 9781402028595 - 9781402028656 ; , s. 129-145
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Ontologies are being used in bioinformatics and systems biology, among others, for communication between people and organizations, as the basis for interoperability between systems, and as query models and indexes to repositories of information. In this chapter we give a background of the area and provide a state of the art overview. We present different possible definitions of ontology, examples of bio-ontologies and their use, formalisms that can be used to represent ontologies as well as tools that support the different stages in the life cycle of an ontology.
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276238.
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276239.
  • Lambrughi, Matteo, et al. (författare)
  • DEAMINATION REACTIONS AS PART OF THE METABOLIC PATHWAY FOR THE PRODUCTION OF ADIPIC ACID
  • 2018
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Deamination of lysine, β-lysine or 2-aminoadipic acid are enzymatic reactions that have great biotechnological interest as part of the metabolic pathways for the production of adipic acid. The enzymatic activity necessary to catalyze the mentioned deamination reactions is defined as ammonia lyase (EC 4.3.1.-) and cleaves the bond between the amine group and adjacent carbon. Whereas ammonia lyases able to act on the target substrates lysine, β-lysine or 2-aminoadipic acid have not been identified so far, ammonia lyases able to act on other amino acids have long been known. We selected 3-methylaspartate-ammonia lyase (MAL, EC 4.3.1.2) as enzyme that potentially could be made active on the target substrates. Three MAL were recombinantly expressed and purified and the activity tested towards the substrates, but no activity was observed. Different MAL single mutant variants potentially able to catalyze the desired reactions were designed using a computational approach, but unfortunately, no activity towards the target substrates was detected. In order to better understand the substrate scope and catalytic mechanism of MAL, different compunds with similar structure to the natural substrate were tried as substrates. MAL showed activity towards aspartic acid, but no towards the other substrates indicating the narrow specificity of the enzyme. Inhibition studies showed that β-lysine was a competitive inhibitor suggesting that the amino group of the substrate need to be in the β-carbon for the binding. 2-aminoadipic acid was shown to be a non-competitive inhibitor. Finally, docking experiments were carried out to understand if the target substrates fit in the catalytic pocket. The study provides a deeper knowledge of the substrate scope and inhibitors of MAL and analyze if and how the target substrates could be deaminated by MAL. Moreover, the study establishes reliable methods for the detection of deamination activity of lysine, β-lysine and 2-aminoadipic acid.
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276240.
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