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Sökning: LAR1:su > Övrigt vetenskapligt/konstnärligt

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61.
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65.
  • Abelein, Axel, 1985- (författare)
  • Modulation of Alzheimer's amyloid β peptide self-assembly : Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease
  • 2015
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Misfolding of proteins and peptides is closely linked to several neurodegenerative disorders, among them Alzheimer's disease (AD), the most prominent example of brain diseases. The self-assembly of the amyloid β peptide (Aβ) into amyloid fibrils is one histologic hallmark of AD. A detailed knowledge about the underlying mechanism(s) of Aβ aggregation is crucial for advances toward a fundamental understanding of the disease, which may promote the search for and design of efficient therapeutics. The work presented in this thesis deals with modulation of the aggregation process by various compounds, i.e. small organic molecules (e.g. lacmoid and Congo red), surfactants and metal ions. These results provide insight into the molecular mechanism of modulator interactions and interference with Aβ and its aggregation pathways. Applying a combination of kinetic and dynamic studies as well as structural investigations we characterized the molecular interactions between Aβ and aggregation modulators in terms of microscopic rate constants, conformational preferences and thermodynamics. An important conclusion is that these modulators form highly dynamic complexes with Aβ, with life-times on the timescale of milliseconds. Despite the similar exchange dynamics, the effect on peptide aggregation is modulator-specific and fibril formation can be accelerated, retarded or inhibited by their interactions. In summary, Aβ self-assembly is governed by microscopic kinetic and dynamic processes that can be altered by aggregation modulators. Further elucidation of these mechanisms is beneficial for the understanding and therapeutic intervention of amyloid diseases.
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69.
  • Abiala, Kristina, 1948- (författare)
  • Säljande samspel : en sociologisk studie av privat servicearbete
  • 2000
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Interaction between people can be seen as a distinctive feature of 'post-industrial society'. In this study I investigate some of the conditions for this encounter in private service work in Sweden. I start by discussing some important concepts: service, service encounter and emotional labour. Three parties in an interactional triangle can be perceived: the service enterprise, the service worker and the customer.The service encounter is embedded in organisational frames. Recruiting for social competence and training for selling interaction are two facets of these frames. In interactive service work, control is complicated by the fact that a third party, the customer, is involved and that the borders between worker, work process and result are somewhat indistinct. Indirect forms of control can be used to affect workers' attitudes and thinking, as well as behaviour.Service work can be described as a form of acting. Different service workers will identify differently with their work role. In my study I observe both positive and negative experiences of work. A majority report that they sometimes are so tired of people that they want to be alone after work.I distinguish two dimensions of interactive service work: type of interaction and sales situation. Interaction can be more or less important, and the sales situation can be more or less concealed. Based on these dimensions I suggest a typology to illustrate some differences between different service occupations. Four types are suggested: (1) Work first, and customer later; (2) Personalised services; (3) Routine selling; and (4) Persuasive selling. In the second group we find the experts of interaction, but also the strongest signs of social strain.
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70.
  • Abouelkomsan, Ahmed, 1995- (författare)
  • Geometry, Topology and Emergence in Moiré Systems
  • 2022
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The experimental discovery of correlated insulators and superconductivity in highly tunable Van der Waals heterostructures, such as twisted bilayer graphene, has highlighted the role of moiré patterns, resulting from tiny relative twists or lattice constant mismatches, in realizing strongly correlated physics. A key ingredient is the existence of very narrow flat bands where interaction effects are dominant.In this thesis and the accompanying papers, we theoretically study a number of experimentally relevant moiré systems. We generally show that strong interactions combined with the geometry and the topology of the underlying flat bands can result in a plethora of distinct quantum many-body phases ranging from topological order to multiferroicity. Of particular importance are lattice analogues of the fractional quantum Hall effect known as fractional Chern insulators. They harbour peculiar phenomena such as fractional charge and statistics and provide a route towards realizing topologically ordered states at high temperature. A ubiquitous feature of the many-body physics is the emergence of unique particle-hole dualities driven by the geometry of band-projected interactions.
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