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Träfflista för sökning "WFRF:(Pagels Joakim) ;pers:(Swietlicki Erik);pers:(Löndahl Jakob)"

Sökning: WFRF:(Pagels Joakim) > Swietlicki Erik > Löndahl Jakob

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  • Löndahl, Jakob, et al. (författare)
  • Experimentally Determined Human Respiratory Tract Deposition of Airborne Particles at a Busy Street
  • 2009
  • Ingår i: Environmental Science & Technology. - : American Chemical Society (ACS). - 1520-5851 .- 0013-936X. ; 43:13, s. 4659-4664
  • Tidskriftsartikel (refereegranskat)abstract
    • Traffic is one of the major sources of harmful airborne particles worldwide. To relate exposure to adverse health effects it is important to determine the deposition probability of the inhaled particles in the human respiratory tract. The size-dependent deposition of 12-580 nm particles was measured with a novel setup in 9 healthy subjects breathing by mouth on the windward side of a busy street in Copenhagen, Denmark. The aerosol was characterized both at the curbside and, to obtain the background concentration, at rooftop level. Particle hygroscopicity, a key parameter affecting respiratory tract deposition, was also measured at the same time of exposure. The total deposition fraction of the curbside particles in the range 12-580 nm was 0.60 by number, 0.29 by surface area, and 0.23 by mass. The deposition fractions of the "traffic exhaust" contribution, calculated as the hydrophobic fraction of the curbside particles, was 0.68, 0.35, and 0.28 by number, surface area, and mass, respectively. The deposited amount of traffic exhaust particles was 16 times higher by number and 3 times higher by surface area compared to the deposition of residential biofuel combustion particles investigated previously (equal inhaled mass concentrations). This was because the traffic exhaust particles had both a higher deposition probability and a higher number and surface area concentration per unit mass. To validate the results, the respiratory tract deposition was estimated by using the well-established ICRP. model. Predictions were in agreement with experimental results when the effects of particle hygroscopicity were considered in the model.
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  • Löndahl, Jakob, et al. (författare)
  • Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review.
  • 2014
  • Ingår i: Journal of Aerosol Medicine and Pulmonary Drug Delivery. - : Mary Ann Liebert Inc. - 1941-2703 .- 1941-2711. ; 27:4, s. 229-254
  • Forskningsöversikt (refereegranskat)abstract
    • Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30-70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data.
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