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| 2. |
- Glantz, Anna, 1959
(författare)
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Intrahepatic cholestasis of pregnancy
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Intrahepatic cholestasis of pregnancy (ICP) is a condition that has been reported to be associated with an increased fetal risk. A prospective study of ICP was conducted in the Västra Götaland region of Sweden between February 1, 1999 and January 31, 2002.Objectives were to study:I) The incidence of pruritus in pregnancy and ICP (defined as serum bile acid levels >10 μmol/L), the complications associated with ICP and whether complication rates correlate with serum bile acid levels, in an observational study with 690 subjects.II) Whether fetal complication rates, laboratory parameters of cholestasis and pruritus could be reduced by treatment with ursodeoxycholic acid (UDCA) or dexamethasone in a randomised, placebo-controlled intervention trial with 130 participants.III) If common haplotypes of the ABCB4-gene and the ABCB11-gene were associated with severe ICP. Fifty-two women with bile acid levels ≥40 μmol/L were included and compared to fifty-two healthy controls.IV) If serum bile acid composition is dominated by cholic acid, if sulphated progesterone metabolites are found in urine and if serum bile acid composition and the relative amounts of sulphated progesterone metabolites would change during treatment with UDCA, dexamethasone or placebo in women with ICP. This study had 39 participants, who were also included in the intervention trial.Results: Of 45,485 pregnancies leading to delivery in the region during the study period, 2,1% were complicated by pruritus of pregnancy and ICP was diagnosed in 1,5%. Of all women with ICP, 81% had the mild form with bile acid levels <40 μmol/L: no increase in fetal risk was found in these cases. Severe ICP (≥40 μmol/L) was diagnosed in 19%; fetal risk (spontaneous preterm delivery, asphyxial events and meconium-staining of amniotic fluid, placenta and membranes) was increased in these pregnancies. No reduction in fetal complications were found in the intervention study. Intention-to-treat-analysis showed reduction of alanine transferase (ALT) and bilirubin levels in the UDCA group. Sub-analysis of women with severe ICP showed reduction of serum bile acids in the UDCA and dexamethasone groups (greater reduction in the UDCA group) but reduction of pruritus was only associated with UDCA treatment. The genetic study showed that common haplotypes of the ABCB4-gene, but not of the ABCB11-gene, are associated with severe ICP. The metabolic study demonstrated ICP is characterised by a dominance (>50%) of cholic acid in the bile acid pool and that sulphated progesterone metabolites are found in ICP patients´ urine. Treatment with UDCA, but not dexamethasone, reduced relative amounts of sulphated progesterone metabolites in urine.Conclusions: ICP occured in 1.5% of the pregnancies. Increased fetal risk was only associated with the severe form (serum bile acids ≥40 μmol/L), found in 19% of the cases. Treatment with UDCA reduced ALT and bilirubin levels regardless of the severity of ICP. In women with severe ICP, UDCA treatment alleviated pruritus and was more effective than dexamethasone in reducing serum bile acid levels. Common haplotypes of the ABCB4-gene were found to be associated with severe ICP. Women with ICP have increased relative amounts of cholic acid in serum and sulphated progesterone metabolite levels in urine, the latter of which was reduced by UDCA.
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| 3. |
- Pineda Huitron, Rosa Maria, et al.
(författare)
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Identification of cracking issues and process improvements through plant monitoring and numerical modelling of secondary cooling during continuous casting of HSLA steels
- 2020
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Ingår i: The Iron and Steel Institute of Japan, ISIJ. - Japan. ; 61:3
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Tidskriftsartikel (refereegranskat)abstract
- A holistic approach to diagnose the occurrence of cracking on HSLA steel slabs and propose countermeasures to prevent them is presented. The approach consisted on plant monitoring, including direct temperature measurements in the strand with pyrometers. Extensive characterization was performed via thermo-mechanical tests and microscopy techniques which revealed combination of Widmanstätten ferrite, acicular ferrite and secondary phases that promote embrittlement during casting with a minimum ductility between 700°C-800°C (± 50 ) which is responsible for cracking in this steel. Finally, 1D and 3D numerical models were developed to test possible cooling strategies which proved that reductions in water flowrate can have a positive effect in slab quality by avoiding the low ductility zone. Corrective actions included decreasing cooling to increase the overall temperature of the strand before the straightener to increase the overall temperature. Yet, some slabs still observed the presence of cracks which points at secondary factors such as high tundish temperatures >1530°C producing cracking. Other secondary factors include strong temperature variations up to ± 250 ºC during measurements which would send the strand corners into the low ductility range producing cracking despite having a hot slab centre. Although these optimization strategies are particular to each caster and steel grade, a similar approach could be applied to address secondary cooling issues during continuous casting. The models presented are an ideal toolkit to analyse the influence of product size and operation parameters in combination with plant monitoring and extensive microstructure characterization to improve the quality and productivity of the process.
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- Abreu, P, et al.
(författare)
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Search for the B-c meson
- 1997
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 398:1-2, s. 207-222
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In a sample of 3.02 million hadronic Z(0) decays collected by the DELPHI detector, 270 J/psi --> e(+)e(-) candidates have been selected. A search for fully reconstructed B-c(+/-) mesons has yielded one B-c(+/-) --> J/psi pi(+/-) candidate, no B-c(+/-) -->
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| 6. |
- Abreu, P, et al.
(författare)
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Search for neutral Higgs bosons in e(+)e(-) collisions at root s=183 GeV
- 1999
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Ingår i: EUROPEAN PHYSICAL JOURNAL C. - : SPRINGER VERLAG. - 1434-6044. ; 10:4, s. 563-604
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Neutral Higgs bosons were searched for in the data collected by DELPHI at a centre-of-mass energy of 183 GeV, corresponding to an integrated luminosity of 54 pb(-1). The production of the lightest neutral Higgs boson with either an on-shell Z boson or a n
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| 7. |
- Abdallah, H, et al.
(författare)
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Res-CR-Net, a residual network with a novel architecture optimized for the semantic segmentation of microscopy images
- 2020
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Ingår i: MACHINE LEARNING-SCIENCE AND TECHNOLOGY. - : IOP Publishing. - 2632-2153. ; 1:4
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Deep neural networks (DNN) have been widely used to carry out segmentation tasks in both electron microscopy (EM) and light/fluorescence microscopy (LM/FM). Most DNNs developed for this purpose are based on some variation of the encoder-decoder U-Net architecture. Here we show how Res-CR-Net, a new type of fully convolutional neural network that does not adopt a U-Net architecture, excels at segmentation tasks traditionally considered very hard, like recognizing the contours of nuclei, cytoplasm and mitochondria in densely packed cells in either EM or LM/FM images.
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| 8. |
- Abdallah, J, et al.
(författare)
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Bose-Einstein correlations in W+W- events at LEP2
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:2, s. 161-174
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Tidskriftsartikel (refereegranskat)abstract
- Bose-Einstein correlations (BEC) between final state particles in the reaction e(+)e(-) -> W+ W- -> q(1)(q(2)) over barq(3)(q(4)over bar>) over bar) have been studied. Data corresponding to a total integrated luminosity of 550 pb(-1), recorded by the DELPHI detector at centre-of-mass energies ranging from 189 to 209 GeV, were analysed. An indication for inter-W BEC between like-sign particles has been found at the level of 2.4 standard deviations of the combined statistical and systematic uncertainties.
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| 9. |
- Abdallah, J, et al.
(författare)
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Determination of A(FB)(b) at the Z pole using inclusive charge reconstruction and lifetime tagging
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 40:1, s. 1-25
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Tidskriftsartikel (refereegranskat)abstract
- A novel high precision method measures the b-quark forward-backward asymmetry at the Z pole on a sample of 3,560,890 hadronic events collected with the DELPHI detector in 1992 to 2000. An enhanced impact parameter tag provides a high purity b sample. For event hemispheres with a reconstructed secondary vertex the charge of the corresponding quark or anti-quark is determined using a neural network which combines in an optimal way the full available charge information from the vertex charge, the jet charge and from identified leptons and hadrons. The probability of correctly identifying b-quarks and anti-quarks is measured on the data themselves comparing the rates of double hemisphere tagged like-sign and unlike-sign events. The b-quark forward-backward asymmetry is determined from the differential asymmetry, taking small corrections due to hemisphere correlations and background contributions into account. The results for different centre-of-mass energies are: A(FB)(b) ( 89.449 GeV) = 0.0637 +/- 0.0143( stat.) +/- 0.0017( syst.), A(FB)(b) ( 91.231 GeV) = 0.0958 +/- 0.0032( stat.) +/- 0.0014( syst.), A(FB)(b) ( 92.990 GeV) = 0.1041 +/- 0.0115( stat.) +/- 0.0024( syst.). Combining these results yields the b-quark pole asymmetry A(FB)(b0) = 0.0972 +/- 0.0030( stat.) +/- 0.0014( syst.).
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| 10. |
- Abdallah, J, et al.
(författare)
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Measurement of the W-pair production cross-section and W branching ratios in e(+)e(-) collisions at root s=161-209 GeV
- 2004
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 127-144
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Tidskriftsartikel (refereegranskat)abstract
- These final results on e(+) e(-) W+ W- production cross-section measurements at LEP2 use data collected by the DELPHI detector at centre-of-mass energies up to 209 GeV. Measurements of total cross-sections, W angular differential distributions and decay branching fractions, and the value of the CKM element |V-cs| are compared to the expectations of the Standard Model. These results supersede all values previously published by DELPHI.
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