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Sökning: db:Swepub > Umeå universitet

  • Resultat 45171-45180 av 85078
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45171.
  • Lindgren, Theres, et al. (författare)
  • Gene expression profiling in MOLT-4 cells during gamma-radiation-induced apoptosis
  • 2012
  • Ingår i: Tumor Biology. - : Springer Science and Business Media LLC. - 1010-4283 .- 1423-0380. ; 33:3, s. 689-700
  • Tidskriftsartikel (refereegranskat)abstract
    • This study aims to identify the temporal changes in gene expression in MOLT-4, a leukemia cell line, in response to radiation and to present a comprehensive description of the pathways and processes that most significantly relate to the cellular biological responses. A global gene expression profile of 24,500 genes was performed on MOLT-4 tumor cells following exposure to 5 Gy of ionizing radiation (Co-60) using a bead chip array (Illumina). Signaling pathways and processes significantly altered following irradiation were explored using MetaCore. Cellular viability [3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], activation of cell cycle checkpoints [fluorescence activated cell sorting (FACS)], and induction of apoptosis (FACS, caspase assays) were evaluated to correlate these biological responses to the gene expression changes. Totally, 698 different genes displayed a significantly altered expression following radiation, and out of these transcripts, all but one showed increased expression. One hour following irradiation, the expression was changed only for a few genes. Striking changes appeared at later time-points. From 3 to 24 h post-irradiation, a significant fraction of the genes with altered expression were found to be involved in cell cycle checkpoints and their regulation (CDKN1A), DNA repair (GADD45A, DDB2, XPC), apoptosis induction (DR5, FasR, Apo-2L, Bax), and T-cell activation/proliferation (CD70, OX40L). Irradiated MOLT-4 cells were arrested at the G2-checkpoint, followed by a decrease in cell viability, most pronounced 48 h after exposure. The cell death was executed by induced apoptosis and was visualized by an increase in subG1 cells and an increased activation of initiator (caspase-8 and caspase-9) and execution (caspase-3) caspases. Activation of cell cycle arrest and apoptosis correlated well in time with the changes in gene expression of those genes important for these biological processes. Activation of the apoptotic signaling pathways in MOLT-4 cells following irradiation includes components from the intrinsic as well as the extrinsic apoptotic pathways. This study indicates that the altered gene expression pattern induced by irradiation is important for the sequential steps observed in MOLT-4 cells during apoptosis induction.
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45172.
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45173.
  • Lindgren, Theres, et al. (författare)
  • Genome wide expression analysis of radiation induced DNA damage responses in isogenic HCT116 p53 +/+ and HCT116 p53 -/- colorectal carcinoma cell lines
  • 2015
  • Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 91:1, s. 99-111
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose : To study the kinetics of gene expression alterations following radiation exposure of isogenic HCT116 p53+/+ and HCT116 p53-/- cell lines. Materials and methods : Cells were exposed to 5 Gy of irradiation (Cs-137) and genome-wide temporal expression analysis using Illumina bead chip arrays was performed. Signalling pathways were explored using Metacore (Genego). Biological responses including cell cycle checkpoint activation, centrosome amplification and senescence induction were analyzed. Results : Significant differences in the radiation response were observed between the p53+/+ and the p53-/- cell lines. In p53+/+ cells concurrent G1- and G2-arrests were activated followed by senescence induction. Increased expression of genes associated with senescence, senescence associated secretory phenotype (SASP) and repression of genes essential for G2-M transition were detected. P53-/- cells arrested mainly in G2 followed by centrosome amplification, mitotic slippage and a subsequent increase of polyploid cells. Furthermore, changes in expression correlated well with these signs of mitotic catastrophe. Conclusions : The presence or absence of p53 triggers different signalling cascades with different endpoints. Elucidating these differences is important as it enables improvement of radiation treatment and could be used to develop new combination treatments with specific inhibitors of key regulators of these cell death modalities.
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45174.
  • Lindgren, Tomas, 1963- (författare)
  • Hjalmar Sundén's Impact on the Study of Religion in the Nordic Countries
  • 2014
  • Ingår i: Temenos. - 0497-1817 .- 2342-7256. ; 50:1, s. 39-61
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, I discuss Hjalmar Sundén’s theoretical and methodological contributions to the psychological study of religion in the Nordic countries, including a discussion of role theory and Sundén’s way of conducting (and presenting) his research. Nordic scholars’ use of role theory is analyzed and discussed. My analysis of the state of research reveals that the use of role theory reached its peak during the 1970s. Scholarly interest in the theory declined during the 1980s, and has been virtually abandoned since the mid-1990s. In these earlier studies, the theory was primarily used to elucidate the psychological dynamic of various religious phenomena, rather than to test the theory systematically against data. However, these scholars gave the theory an empirical underpinning, and identified details in the theory that needed to be refined and revised. I propose several possible reasons for the decline in scholarly interest in role theory. Finally, I suggest that Sundén’s methodological contributions may have had a bigger impact on the study of religion than his theoretical contributions.
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45175.
  • Lindgren, Tomas, 1963- (författare)
  • Islam i Sydostasien
  • 2015
  • Ingår i: Islam. - Stockholm : Liber. - 9789147112043 ; , s. 245-256
  • Bokkapitel (refereegranskat)
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45176.
  • Lindgren, Tomas, 1963- (författare)
  • Islam i Sydostasien
  • 2021. - 2
  • Ingår i: Islam. - Stockholm : Liber. - 9789147143702 ; , s. 229-238
  • Bokkapitel (refereegranskat)
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45177.
  • Lindgren, Tomas, 1963- (författare)
  • Kultur- och religionsmöten under fältstudier
  • 2011
  • Ingår i: Verktyg för ökad förståelse. - Stockholm : Svenska Missionsrådet. - 9185141143 ; , s. 30-34
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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45178.
  • Lindgren, Therese, 1977-, et al. (författare)
  • Longitudinal analysis of the human T cell response during acute hantavirus infection
  • 2011
  • Ingår i: Journal of Virology. - Baltimore : American Society for Microbiology. - 0022-538X .- 1098-5514. ; 85:19, s. 10252-10260
  • Tidskriftsartikel (refereegranskat)abstract
    • Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally analyzed the primary CD8 T cell response in infected individuals from the first onset of clinical symptoms until viral clearance. A vigorous CD8 T cell response was observed early following the onset of clinical symptoms, determined by the presence of high numbers of Ki67(+)CD38(+)HLA-DR(+) effector CD8 T cells. This response encompassed up to 50% of total blood CD8 T cells, and it subsequently contracted in parallel with a decrease in viral load. Expression levels of perforin and granzyme B were high throughout the initial T cell response and likewise normalized following viral clearance. When monitoring regulatory components, no induction of regulatory CD4 or CD8 T cells was observed in the patients during the infection. However, CD8 as well as CD4 T cells exhibited a distinct expression profile of inhibitory PD-1 and CTLA-4 molecules. The present results provide insight into the development of the T cell response in humans, from the very onset of clinical symptoms following a viral infection to resolution of the disease.
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45179.
  • Lindgren, Tomas, 1963-, et al. (författare)
  • Mahatma Gandhi, neoliberalism, and the bourgeois study of spirituality
  • 2020
  • Ingår i: Research in the Social Scientific Study of Religion. - : Brill Academic Publishers. - 9789004443969 - 9789004443488 ; , s. 43-62
  • Bokkapitel (refereegranskat)abstract
    • In psychological literature, the concept of spirituality is typically defined as something private, internal and experiential that includes meaning-making, sacred values, connectedness, and/or transcendence. Thus, spirituality is distinct from social, economic, and political spheres of human life. Most scholars who concern themselves with spirituality assume that it is a universal phenomenon that is essentially the same everywhere. But the isolation of spirituality as a sphere of life that is separated from other spheres is not a universal feature of human history. Mahatma Gandhi, who argued that spirituality is associated with political activism and the struggle for social and economic justice, illustrates this point. Spirituality is a modern concept with a specific history and what counts as spirituality and what does not depend on different configurations of power. In this paper, we explore why a category as amorphous and indeterminate as spirituality has maintained such a currency in the literature of the psychology of religion. We argue that the category of spirituality is a sociopolitical management technique for reinforcing political quietism, which is necessary for the maintenance of the neoliberal status quo.
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45180.
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