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Träfflista för sökning "AMNE:(SOCIAL SCIENCES Business and economics) "

Sökning: AMNE:(SOCIAL SCIENCES Business and economics)

  • Resultat 1-10 av 78094
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1.
  • Colomer, Laia, 1967- (författare)
  • Commentary: On Time Travelling and Cinema
  • 2017
  • Ingår i: The Archaeology of Time Travel. - Oxford : Archaeopress. - 9781784915018 - 9781784915001 ; , s. 229-232
  • Bokkapitel (refereegranskat)
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2.
  • Moons, Philip, 1968, et al. (författare)
  • The COVID-19 pandemic as experienced by adults with congenital heart disease from Belgium, Norway, and South Korea: impact on life domains, patient-reported outcomes, and experiences with care.
  • 2022
  • Ingår i: European journal of cardiovascular nursing. - : Oxford University Press (OUP). - 1873-1953 .- 1474-5151. ; 21:6, s. 620-629
  • Tidskriftsartikel (refereegranskat)abstract
    • The coronavirus disease-2019 (COVID-19) pandemic poses significant challenges to many groups within societies, and especially for people with chronic health conditions. It is, however, unknown whether and how the pandemic has thus far affected the physical and mental health of patient populations. Therefore, we investigated how the pandemic affected the lives of adults with congenital heart disease (CHD), compared pre- and peri-pandemic patient-reported outcome measures (PROMs) and a patient-reported experience measure (PREM), and investigated whether having had COVID-19 impacted pre-/peri-pandemic differences of the PROMs and PREM.As part of the ongoing APPROACH-IS II project, we longitudinally surveyed 716 adults with CHD from Belgium, Norway, and South Korea. Pre-pandemic measures were administered from August 2019 to February 2020 and the peri-pandemic surveys were completed September 2020-April 2021. The majority of patients indicated that their social lives (80%), mental health (58%), and professional lives/education (51%) were negatively impacted by the pandemic. Patients felt worried (65%), were afraid (55%), reported the pandemic felt 'close' to them (53%), and were stressed (52%). However, differences between pre- and peri-pandemic scores on the PROMs and PREM were negligibly small (Cohen's d < 0.20). Across measures, 5.8-15.8% of patients demonstrated changes (improved or worsened scores) that exceeded the minimal clinically important difference. There were no difference-in-differences for PROMs and PREM between patients who did vs. did not have COVID-19.Although the COVID-19 pandemic has been disruptive in many ways, pre- to peri-pandemic changes in PROMs and PREM of adults with CHD were negligibly small.
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  • Moons, Philip, 1968 (författare)
  • The medical system, focusing on transitional care
  • 2023
  • Ingår i: The 24th Annual Meeting of Japanese Society for Adult Congenital Heart Disease. Matsuyama, Japan.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Kleman, Marika I (författare)
  • Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles
  • 1996
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. Both PhIP and MeIQx were able to induce foci of initiated cells, indicating that both these compounds may be involved in initiation of carcinogenesis. HCA have been reported to induce xenobiotic metabolizing enzymes of the cyto-chrome P450 lA (CYPlA) subfamily, most notably the CYPlA2 isoform. The regulatory mechanism of the CYPlA induction by HCA is, however, unclear. Studies in vivo in rats and in primary hepatocyte cultures revealed that MeIQx induced both CYPlA1/lA2 proteins and the corresponding catalytic activities. The CYP induction pattern by HCA was reflected at the steady state mRNA levels in the hepatocytes as measured by solution hybridization technique. In contrast to previous studies, no preferential induction of CYPlA2 was observed in the present study. CYPlA1 and CYPlA2 are target genes of the intracellular dioxin receptor. This receptor interacts with xenobiotic response elements (XREs) of target promoters upon binding the environmental pollutant dioxin or related compounds. HCA exhibited capacity to activate the dioxin receptor to a form which interacts with XRE in vitro. Taken together, these results suggest that MeIQx regulates both CYPlA isozymes by the same mechanism involving the dioxin receptor. Another group of putative dioxin receptor ligands of dietary origin are the indolo-carbazoles, that may be produced in vivo under acidic conditions from precursor molecules in cruciferous plants. Indolo[3,2-b]carbazole and its dimethylated derivative potently regulated gene expression of a reporter gene driven by a minimal XRE in both mouse and human hepatoma cells. The indolocarbazole-induced human receptor appeared to form more stable complexes with XRE in vitro relative to those generated by the dioxin-activated receptor. This indicate that the indolocarbazoles and dioxin possess different mechanistic qualities with respect to activation of human dioxin receptor function. This study indicates that the HCA and the indolocarbazoles both represent distinct classes of dietary dioxin receptor agonists. The HCA are weak agonists, but are consumed in relatively high amounts, while the indolocarbazoles are high affinity ligands presumably present in considerably lower amounts in diet.
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