| 841. |
- Kihlander, Ingrid, 1976-, et al.
(författare)
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Ledningssystem för innovation : Reflektioner kring en ledningssystemstandard för innovationsarbete
- 2022
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Ingår i: MGMT Management of Innovation and Technology. - Göteborg. - 1102-5581. ; :2, s. 5-7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- En vägledande ISO-standard för innovationsledningssystem (ISO 56002) publicerades 2019. Den ger möjlighet att följa hur ett sådant ramverk kan stödja organisationer som vill stärka sin innovationsförmåga med hjälp av en systemansats. Den här artikeln delar insikter från fallstudier bland annat på organisationer som uttalat har använt ISO-standarden för att implementera ett innovationsledningssystem.
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| 842. |
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| 843. |
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| 844. |
- Kilpeläinen, Tuomas O, et al.
(författare)
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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
- 2011
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:8, s. 753-60
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
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| 845. |
- Kilpeläinen, Tuomas O, et al.
(författare)
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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
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| 846. |
- Kindblom, Jenny, 1971, et al.
(författare)
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Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men
- 2009
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Ingår i: Journal of bone and mineral research. - : Wiley. - 1523-4681 .- 0884-0431. ; 24:5, s. 785-91
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Tidskriftsartikel (refereegranskat)abstract
- The osteoblast-derived protein osteocalcin has recently been shown to affect adiposity and glucose homeostasis in mice, suggesting that the skeleton influences energy metabolism through an endocrine mechanism. The aim of this study was to investigate the relationship between plasma osteocalcin and parameters reflecting fat mass and glucose homeostasis in humans. Fasting levels of plasma osteocalcin, plasma glucose, serum insulin, and lipids were analyzed in elderly men (75.3 +/- 3.2 yr of age) in the Gothenburg part (all subjects, n = 1010; nondiabetic, n = 857; diabetic, n = 153) of the MrOS Sweden study. Fat mass and lean mass were analyzed using DXA. Diabetic subjects had lower plasma osteocalcin (-21.7%, p < 0.001) than nondiabetic subjects. For both all subjects and nondiabetic subjects, plasma osteocalcin was clearly inversely related to body mass index (BMI), fat mass, and plasma glucose (p < 0.001), whereas it was not associated with height or lean mass. Plasma osteocalcin explained a substantial part (6.3%) of the variance in plasma glucose, whereas it associated moderately with serum insulin. Multiple linear regression models adjusting for serum insulin and fat mass showed that plasma osteocalcin was an independent negative predictor of plasma glucose (p < 0.001). We herein, for the first time in humans, show that plasma osteocalcin is inversely related to fat mass and plasma glucose. Although one should be cautious with mechanistic interpretations of cross-sectional association studies, our human data support recently published experimental studies, showing endocrine functions of osteoblast-derived osteocalcin on glucose and fat homeostasis.
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| 847. |
- Klugman, Sofia, et al.
(författare)
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A Scandinavian chemical wood-pulp mill : Part 1. Energy audit aiming at efficiency measures
- 2007
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Ingår i: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 84:3, s. 326-339
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish wood-pulp mill is surveyed in terms of energy supply and use in order to determine the energy-saving potential. Conservation measures are of increasing interest to Swedish industry, as energy prices have continued to rise in recent years. The electricity price particularly increased after the deregulation of the Scandinavian electricity market in 1996. The deregulation expanded to all of the EU in July 2004, which may increase the Swedish electricity price further until it reaches the generally higher European price level. Furthermore, oil prices have increased and the emissions trading scheme for CO2 adds to the incentive to reduce oil consumption. The energy system at the surveyed pulp mill is described in terms of electricity and process heat production and use. The total energy-saving potential is estimated and some saving points are identified. The heat that today is wasted at the mill has been surveyed in order to find potential for heat integration or heat export. The result shows that the mill probably could become self-sufficient in electricity. Particularly important in that endeavor is updating old pumps.
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| 848. |
- Klugman, Sofia, et al.
(författare)
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A Scandinavian chemical wood-pulp mill : Part 2. International and model mills comparison
- 2007
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Ingår i: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 84:3, s. 340-350
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Tidskriftsartikel (refereegranskat)abstract
- The energy use at a Swedish chemical wood-pulp mill is compared internationally and for two model mills that aim to use the most efficient available technology. The international comparison is performed between Canadian and Scandinavian pulp-mills on a general level, and on a closer level among eleven Swedish and Finnish non-integrated sulfate pulp-mills, the type of mill considered in the case study. The two model mills that are used for comparison are one Swedish and one Canadian. The Scandinavian pulp-mills are somewhat more energy efficient than the Canadian mills. Still, the variation in energy use is remarkably large among the Scandinavian mills, which indicates that the energy-saving potential is great. If all Swedish freestanding sulfate pulp-mills became as energy efficient as the most efficient Scandinavian mill, electricity savings corresponding to nearly 1% of the national electricity use would be obtained. In the model mills comparison it was found that large amounts of heat could be saved, particularly in the evaporation plant.
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| 849. |
- Klugman, Sofia, et al.
(författare)
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A Swedish integrated pulp and paper mill - Energy optimisation and local heat cooperation
- 2009
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Ingår i: Energy Policy. - : Elsevier BV. - 0301-4215 .- 1873-6777. ; 37:7, s. 2514-2524
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Tidskriftsartikel (refereegranskat)abstract
- Heat cooperation between industries and district heating companies is often economically and environmentally beneficial. In this paper, energy cooperation between an integrated Swedish pulp and paper mill and two nearby energy companies was analysed through economic optimisations. The synergies of cooperation were evaluated through optimisations with different system perspectives. Three changes of the energy system and combinations of them were analysed. The changes were process integration, extending biofuel boiler and turbine capacity and connection to a local heat market. The results show that the single most promising system change is extending biofuel and turbine capacity. Process integration within the pulp and paper mill would take place through installing evaporation units that yield less excess heat but must in this particular case be combined with extended biofuel combustion capacity in order to be beneficial. Connecting to the local heat market would be beneficial for the pulp and paper mill, while the studied energy company needs to extend its biofuel capacity in order to benefit from the local heat market. Furthermore, the potential of reducing CO2 emissions through the energy cooperation is shown to be extensive; particularly if biofuel and turbine capacity is increased.
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| 850. |
- Klugman, Sofia, et al.
(författare)
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An integrated chemical pulp and paper mill : energy audit and perspectives on regional cooperation
- 2006
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Ingår i: ECOS 2006. - 9608758416 ; , s. 637-644
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Konferensbidrag (populärvet., debatt m.m.)abstract
- As a case study, an energy audit was performed at an integrated pulp and paper mill. A top-down approach was applied to identify and categorize the use of electricity, steam and hot water and the results of the audit are presented in this paper. Also, the connections and cooperation with both the nearby district heating system and a local steam deliverer, partly owned by the mill, are described. Potential ways to save energy are pointed out and changes in the cooperation are discussed. Moreover, a discussion of how the system can benefit from the taxation structure is presented, as the design of the studied system, in combination with the introduction of tradable green certificates, creates possibilities to exploit such benefits. As a result from this design it is shown that the introduction of these certificates promotes the use of oil to produce electricity.
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