| 1. |
- Ahlqvist, Emma, et al.
(författare)
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High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
- 2011
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Ingår i: Human Molecular Genetics. - Oxford : Oxford University Press. - 0964-6906 .- 1460-2083. ; 20:15, s. 3031-3041
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Tidskriftsartikel (refereegranskat)abstract
- Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an inbred-outbred cross design, we identified and fine-mapped CIA loci on a genome-wide scale. Heterogeneous stock mice were first intercrossed with an inbred strain, B10.Q, to introduce an arthritis permitting MHCII haplotype. Homozygous H2(q) mice were then selected to set up an F(3) generation with fixed major histocompatibility complex that was used for arthritis experiments. We identified 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset and fine-mapped a number of previously mapped loci. © The Author 2011. Published by Oxford University Press. All rights reserved.
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| 2. |
- Albinsson, John, et al.
(författare)
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Combined use of Iteration, Quadratic Interpolation and an Extra Kernel for high-resolution 2D particle tracking : a first evaluation
- 2010
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Ingår i: 2010 ieee international ultrasonics symposium. - New York : IEEE Press. - 9781457703829 ; , s. 2000-2003
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Konferensbidrag (refereegranskat)abstract
- A novel 2D particle tracking method, that uses 1) iteration, 2) fast quadratic sub-pixel estimation (with only 28 multiplications per movement), and 3) a previous kernel, has been evaluated and compared with a full-search block-matching method. The comparison with high-frequency ultrasound data (40 MHz) was conducted in silico and on phantoms, which comprised lateral, diagonal, and ellipsoidal movement patterns with speeds of 0–15 mm/s. The mean tracking error was reduced by 68% in silico and 71% for the phantom measurements. When only sub-pixel estimation was used, the decrease in the tracking error was 61% in silico and 57% for the phantom measurements. As well as decreasing the tracking error, the new method only used 70% of the computational time needed by the full-search block-matching method. With a fast method having good tracking ability for high-frequency ultrasound data, we now have a tool to better investigate tissue movements and its dynamic functionality.
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| 3. |
- AlNasseri, Hammad Abdullah, et al.
(författare)
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Towards a Taxonomy of Planning and Scheduling Methods in the Context of Construction Management.
- 2013
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Ingår i: [Host publication title missing]. - Trondheim : Akademika forlag. - 9788232102730 ; , s. 570-581
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Konferensbidrag (refereegranskat)abstract
- Planning and scheduling are considered as one of the most difficult but most important processes from perspectives of project management. These processes involve implementation of a widerange of planning methods used by different organizations with various levels of planning knowledge. The planning methods for scheduling can be classified as traditional methods (e.g. line of balance, Gantt chart and critical path) and modern methods (e.g. last planner and critical chain). Over time these methods had advanced from paper based to computer based. However, some project planners still prefer using the traditional methods despite other new alternatives. Users of those methods have different perspectives about the efficiency and effectiveness of the different planning methods used to manage different projects. Evidences from the secondary data found from extensive literatures have been used to assess the planning and scheduling methods mentioned above. A taxonomy describing each of the method in terms of their theories, key features, application areas, benefits and limitations is presented. The preliminary outcome of this paper may provide a tool to aid organizations in selecting and prioritizing the most appropriate methods to be developed and implemented in planning and scheduling of their projects. It also initializes a theoretical base for more rapid taxonomy studies on the use of different planning and scheduling approaches. As an overall, the present paper reminds practitioners of common ground about its important insights on how such taxonomy studies have potential to make scope of those methods and tools clearer, especially when they compare among them within the same application contexts.
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| 4. |
- Andersson, Janicke, et al.
(författare)
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En skola i toppform!
- 2012
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Ingår i: Fostran av framtidens medborgare : normer och praktiker bortom välfärdsstaten. - Lund : Sekel Bokförlag. - 9789185767731
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Bokkapitel (refereegranskat)
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| 5. |
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| 6. |
- Andersson, Maria, et al.
(författare)
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Chronic widespread pain in patients with rheumatoid arthritis and the relation between pain and disease activity measures over the first 5 years
- 2013
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Ingår i: Journal of Rheumatology. - Toronto, ON : Journal of Rheumatology Publishing. - 0315-162X .- 1499-2752. ; 40:12, s. 1977-1985
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study the prevalence of chronic widespread pain (ChWP), chronic regional pain (ChRP), and fibromyalgia in patients with early rheumatoid arthritis (RA) followed for 5 years after inclusion, and to study the effect of pain on measures of disease activity and function.METHODS: A questionnaire was sent to 1910 patients participating in the Better Anti-Rheumatic Pharmacotherapy study. The responders (73%) were divided into 3 groups according to the reported pain duration and distribution - patients having no chronic pain (NChP), ChWP, and ChRP. Outcome measures were the 28-joint Disease Activity Score (DAS28), the Health Assessment Questionnaire (HAQ), and C-reactive protein (CRP).RESULTS: Thirty-four percent of respondents reported ChWP, 46% ChRP, and 20% NChP. Patients reporting ChWP were more often women and had more pain and tender joints at inclusion. From 6 months to 5 years of followup, mean DAS28, visual analog scale (VAS) pain, VAS global health, and HAQ were significantly higher in the ChWP group than in the other groups. However, all groups showed a similar pattern in swollen joint count, erythrocyte sedimentation rate (ESR), and CRP. From 12 months the ChWP group was treated with prednisolone to a greater extent than the ChRP group, and it had a rate of treatment with disease-modifying antirheumatic drugs similar to that of the ChRP group.CONCLUSION: ChWP is a common feature in RA, more associated with high values for variables related to pain such as the DAS28 and HAQ than to indicators of ongoing inflammation such as swollen joint count, ESR, and CRP. Patients with ChWP should be identified so that adequate treatment also of the noninflammatory pain may be instituted.
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| 7. |
- Andersson, Maria, et al.
(författare)
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The effect of snuff (smokeless tobacco) on disease activity and function in rheumatoid arthritis : experiences from the Better Anti-Rheumatic FarmacOTherapy, a longitudinal multicenter study on early rheumatoid arthritis.
- 2013
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Ingår i: Journal of clinical rheumatology. - Philadelphia, PA : Lippincott Williams & Wilkins. - 1076-1608 .- 1536-7355. ; 19:1, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: It is not known whether snuff (moist smokeless tobacco) affects disease activity in rheumatoid arthritis (RA).OBJECTIVE: This study aims to study the effect of snuff on disease activity and function in Swedish patients with early RA.METHODS: Between 1992 and 2005, 2800 adult patients were included in the Better Anti-Rheumatic FarmacOTherapy (BARFOT) early RA study in Sweden. Disease Activity Score 28 joints (DAS28), Health Assessment Questionnaire, visual analog scale for general health, and drug treatment were registered at inclusion and at follow-up after 1, 2, and 5 years. European League Against Rheumatism response and remission criteria were applied at 1 year. In 2010, a self-completed postal questionnaire was sent to 2102 patients in the BARFOT study enquiring about lifestyle factors such as smoking and use of snuff. Three controls for each patient using snuff were identified.RESULTS: Fifty-one patients who used snuff were identified, together with 145 controls. When we adjusted for socioeconomic class, disease duration, and previous antirheumatic medication, the snuff users had lower DAS28 values at up to 6 months of follow-up than patients who had never smoked, and they had lower DAS28 values than previous smokers at up to 2 years of follow-up. No effect of snuff use on European League Against Rheumatism response was seen at up to 1 year.CONCLUSIONS: Snuff users initially had lower DAS28 levels than never smokers and previous smokers. Copyright © 2013 by Lippincott Williams & Wilkins.
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| 8. |
- Andersson, Maria, et al.
(författare)
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The Effect of Socioeconomic Class and Immigrant Status on Disease Activity in Rheumatoid Arthritis : Data from BARFOT, a Multi-Centre Study of Early RA
- 2013
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Ingår i: Open Rheumatology Journal. - Bussum : Bentham Open. - 1874-3129. ; 7, s. 105-11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: There have been no reports on the effect of immigrant status and socioeconomic status on outcome in rheumatoid arthritis (RA) in Sweden.METHODS: Between 1992 and 2006, 2,800 patients were included in the BARFOT study on early RA in Sweden. Disease Activity Score 28 joints (DAS28), Health Assessment Questionnaire (HAQ), treatment and European League Against Rheumatism (EULAR) response criteria were registered. In 2010, 1,430 patients completed a questionnaire enquiring about demographics and lifestyle factors.RESULTS: One hundred and thirty-nine of the 1,430 patients (9.7%) were immigrants. At baseline immigrants had higher mean HAQ (1.2 vs 0.97 for non-immigrants, p=0.001), DAS28 (5.6 vs 5.2, p=0.000), visual analog scale (VAS) pain (56 mm vs 45 mm, p=0.000), VAS global health (53 mm vs 44 mm, p=0.000) and tender joint count (TJC) (10 vs 8, p=0.000). These differences persisted for up to 2 years of follow-up (for HAQ, for up to 8 years of follow-up). Immigrant status did not have any effect on swollen joint count (SJC), ESR, CRP or EULAR response. Socioeconomic class did not have any effect on treatment or outcome.CONCLUSIONS: Immigrants scored worse in pain, function and TJC for up to 2 years of follow-up, but they did not differ from non-immigrants in objective measures of inflammation or EULAR outcome. This could be due to different perceptions of health and pain and/or the stress of immigration. Socioeconomic class had no effect on treatment or outcome, and this could be due to the relatively egalitarian society in Sweden.
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| 9. |
- Andreasson, E., et al.
(författare)
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Patients treated for psychosis and their perceptions of care in compulsory treatment : basis for an action plan
- 2012
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Ingår i: Journal of Psychiatric and Mental Health Nursing. - Chichester : Wiley-Blackwell. - 1351-0126 .- 1365-2850. ; 19:1, s. 15-22
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the study was to describe patients' conceptions and experiences of care in compulsory treatment for acute onset of psychosis. Twelve patients with experience of compulsory treatment were interviewed in 2008-2009, and phenomenographic analysis was used to analyse the data. Two descriptive categories emerged in the results: receiving needed support and perceiving respectful care. Patients perceived that coercive interventions were positive if they were given good care, if they were given the shelter they needed, if they got help with understanding and if the setting was healing. Patients felt respected if they were treated like human beings, if they were allowed to retain as much of their autonomy as possible and if they were invited to participate even though they were under compulsory treatment. The results show that it is important to prevent patients from being traumatized during compulsory treatment and to take advantage of patients' inner resources. Patients' experiences of compulsory treatment can form the basis for preparing an individual action plan for future compulsory treatment. Individual action plans could empower patients during compulsory treatment and improve their experience of care.
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| 10. |
- Argento, Daniela, et al.
(författare)
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The ‘externalisation’ of local public service delivery : experience in Italy and Sweden
- 2010
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Ingår i: International Journal of Public Policy. - Olney : InderScience Publishers. - 1740-0600 .- 1740-0619. ; 5:1, s. 41-56
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, the local government sector in European countries has undergone important changes involving, among other things, the externalisation of local public service provision through various forms of corporatisation, public-public collaboration, public-private partnerships and contracting out. An important consequence of these institutional changes has been the recasting of local governance systems through the need for increased cooperation between public and private actors. This article addresses these matters with comparative reference to the experience in Italy and Sweden. In doing so, it considers local governments in their constitutional and legal contexts, leading to more detailed discussions of their externalisation initiatives and resultant organisational forms and governance arrangements. Issues of ownership have been important concerning the significance of 'community' and 'place' in the management of public affairs. © 2010 Inderscience Enterprises Ltd.
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