| 311. |
- Fazey, Ioan, et al.
(author)
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Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
- 2020
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In: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
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Journal article (peer-reviewed)abstract
- Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
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| 312. |
- Fedulova, Natalia, 1980-, et al.
(author)
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Expression and purification of catalytically active human PHD3 in Escherichia coli.
- 2007
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In: Protein expression and purification. - : Elsevier BV. - 1046-5928 .- 1096-0279. ; 54:1, s. 1-10
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Journal article (peer-reviewed)abstract
- Transcription factor HIF-1 is a key regulator in cellular adaptation to hypoxia. HIF prolyl hydroxylases (PHDs) control HIF-1 accumulation by hydroxylation dependent on molecular oxygen. Due to this regulation, PHDs have been pointed out as potential drug targets. We have purified catalytically active human PHD3 after heterologous expression in Escherichia coli. Histidine-tagged enzyme was isolated as monomer by immobilized Ni-affinity chromatography followed by gel filtration. Overexpression of bacterial chaperonins GroEL/ES at 30 degrees C substantially increased the yield of soluble PHD3. High concentrations of salt and reducing agent during purification prevented protein aggregation. The enzyme activity with peptide derived from HIF-1alpha was inhibited by Zn(2+), desferrioxamine and imidazole. The hydroxylation activity was verified by mass spectrometry, and Pro567 in HIF-1alpha was discovered as a new site of hydroxylation.
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| 313. |
- Femenias, Paula, 1966, et al.
(author)
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How well do policies for energy efficiency and heritage values in the Swedish housing stock work
- 2021
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In: IOP Conference Series: Earth and Environmental Science. - : IOP Publishing. - 1755-1307 .- 1755-1315. ; 863:1
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Conference paper (peer-reviewed)abstract
- This paper investigates how societal goals of heritage conservation and energy efficiency are handled in the management of Swedish multi-residential buildings. Interviews were made with larger owners of multi-residential stocks, and their perspectives are compared to officials at the City Planning Offices in two Swedish municipalities: Göteborg and Gotland. The questions posed are: How is heritage prioritised in relation to increased energy efficiency, climate impact and other objectives such as cost-efficiency? How important are their internal policies in comparison with external policies imposed by society? The companies express that they are proud of the heritage of their building stock, but they have not integrated heritage values in their management plans and strategies. Social issues such as safety and well-being are included, but not heritage. A consequence of this lack of systematic consideration of heritage is that measures for increased energy efficiency may conflict with conservation needs. In order for heritage values to be taken more seriously in relation to energy efficiency they would need to be integrated into such plans. The benefit from integrating heritage values in sustainable housing management is a question that should be further studied. The paper refers to SDGs 3, 11 and 13.
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| 314. |
- Femenias, Paula, 1966, et al.
(author)
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Renovating the Housing Stock Built Before 1945: Exploring the Relations Between Energy Efficiency, Embodied Energy and Heritage Values
- 2018
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In: Springer Proceedings in Energy: Cold Climate HVAC 2018, Kiruna, Sweden, 12-15 March, 2018. - Cham : Springer International Publishing. - 9783030006617 - 9783030006624 ; , s. 291-301
-
Conference paper (peer-reviewed)abstract
- Swedish multi-family buildings constructed before 1945 constitutes an important part of the national built heritage. However, the majority does not have a formal heritage protection. Part of this building stock has already been renovated, notably through earlier energy saving programmes where additional exterior insulation, new façades and windows were frequently installed with little consideration for the original architecture. Now, 40 years later, these buildings face new renovations. This provides opportunities to improve the energy efficiency, indoor climate and user comfort. At the same time, the original architectural and historical characters lost in previous renovations could be recreated. In this paper, an inter-disciplinary research team illustrates the challenges met in practice to reach a sustainable renovation based on three cases. The case buildings are so-called "Landshövdingehus”, constructed in the 1930s and owned by a public housing company. The relations between building physics, energy efficiency, embodied energy, and the effect on heritage aspects in renovation are studied. The results demonstrate the potential to reach 30% calculated energy efficiency without investing in ventilation systems. When comparing embodied energy to savings in operational energy a short payback time is achieved. However, focusing on the replacement of windows, the cases illustrate difficulties to recreate heritage values at same time as achieving an air-tight and energy efficient construction. In order to improve the results from a heritage point of view, there is a need for quality assurance of the renovation and building permit process.
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| 315. |
- Fialková, Vendy, et al.
(author)
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LibINVENT: Reaction-based Generative Scaffold Decoration for in Silico Library Design
- 2022
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In: Journal of Chemical Information and Modeling. - : American Chemical Society (ACS). - 1549-960X .- 1549-9596. ; 62:9, s. 2046-2063
-
Journal article (peer-reviewed)abstract
- Because of the strong relationship between the desired molecular activity and its structural core, the screening of focused, core-sharing chemical libraries is a key step in lead optimization. Despite the plethora of current research focused on in silico methods for molecule generation, to our knowledge, no tool capable of designing such libraries has been proposed. In this work, we present a novel tool for de novo drug design called LibINVENT. It is capable of rapidly proposing chemical libraries of compounds sharing the same core while maximizing a range of desirable properties. To further help the process of designing focused libraries, the user can list specific chemical reactions that can be used for the library creation. LibINVENT is therefore a flexible tool for generating virtual chemical libraries for lead optimization in a broad range of scenarios. Additionally, the shared core ensures that the compounds in the library are similar, possess desirable properties, and can also be synthesized under the same or similar conditions. The LibINVENT code is freely available in our public repository at https://github.com/MolecularAI/Lib-INVENT. The code necessary for data preprocessing is further available at: https://github.com/MolecularAI/Lib-INVENT-dataset.
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| 316. |
- Filate, Tadele Tamenu, 1994, et al.
(author)
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Aqueous Processed All-Polymer Solar Cells with High Open-Circuit Voltage Based on Low-Cost Thiophene-Quinoxaline Polymers
- 2024
-
In: ACS Applied Materials & Interfaces. - : American Chemical Society (ACS). - 1944-8252 .- 1944-8244. ; 16:10, s. 12886-12896
-
Journal article (peer-reviewed)abstract
- Eco-friendly solution processing and the low-cost synthesis of photoactive materials are important requirements for the commercialization of organic solar cells (OSCs). Although varieties of aqueous-soluble acceptors have been developed, the availability of aqueous-processable polymer donors remains quite limited. In particular, the generally shallow highest occupied molecular orbital (HOMO) energy levels of existing polymer donors limit further increases in the power conversion efficiency (PCE). Here, we design and synthesize two water/alcohol-processable polymer donors, poly[(thiophene-2,5-diyl)-alt-(2-((13-(2,5,8,11-tetraoxadodecyl)-2,5,8,11-tetraoxatetradecan-14-yl)oxy)-6,7-difluoroquinoxaline-5,8-diyl)] (P(Qx8O-T)) and poly[(selenophene-2,5-diyl)-alt-(2-((13-(2,5,8,11-tetraoxadodecyl)-2,5,8,11-tetraoxatetradecan-14-yl)oxy)-6,7-difluoroquinoxaline-5,8-diyl)] (P(Qx8O-Se)) with oligo(ethylene glycol) (OEG) side chains, having deep HOMO energy levels (∼−5.4 eV). The synthesis of the polymers is achieved in a few synthetic and purification steps at reduced cost. The theoretical calculations uncover that the dielectric environmental variations are responsible for the observed band gap lowering in OEG-based polymers compared to their alkylated counterparts. Notably, the aqueous-processed all-polymer solar cells (aq-APSCs) based on P(Qx8O-T) and poly[(N,N′-bis(3-(2-(2-(2-methoxyethoxy)-ethoxy)ethoxy)-2-((2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-methyl)propyl)naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl)-alt-(2,5-thiophene)] (P(NDIDEG-T)) active layer exhibit a PCE of 2.27% and high open-circuit voltage (VOC) approaching 0.8 V, which are among the highest values for aq-APSCs reported to date. This study provides important clues for the design of low-cost, aqueous-processable polymer donors and the fabrication of aqueous-processable OSCs with high VOC
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| 317. |
- Fink, Helen, 1978, et al.
(author)
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An in vitro study of blood compatibility of vascular grafts made of bacterial cellulose in comparison with conventionally-used graft materials
- 2011
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In: Journal of Biomedical Materials Research - Part A. - : Wiley. - 1549-3296 .- 1552-4965. ; 97A:1, s. 52-58
-
Journal article (peer-reviewed)abstract
- In this study we analyzed the blood compatibility of bacterial cellulose (BC) as a new biosynthetic material for use as a vascular graft. As reference materials we used expanded polytetrafluoroethylene (ePTFE) and poly(ethylene terephthalate) (PET) vascular grafts. These materials are in clinical use today. Tubes with inner diameters of both 4 (not PET) and 6 mm were tested. Heparin-coated PVC tubes (hepPVC) were used as a negative control. Platelet consumption and thrombin-antithrombin complex (TAT) were used as parameters of coagulation and for complement activation, sC3a and sC5b-9 were used. The investigated parameters were measured after 1-h exposure to freshly drawn human blood supplemented with a low dose of heparin in a Chandler loop system. The results showed that BC exhibits no significant difference in platelet consumption, as compared with PET 16 mm), ePTFE and hepPVC. The PET material consumed more platelets than any of the other materials. The TAT generation for 4 mm tubes was not significantly different between BC and the other materials. For 6 mm tubes, however, differences were observed between hepPVC and PET (p < 0.0001); BC and hepPVC (p = 0.0016); ePTFE and PET (p < 0.0001); BC and ePTFE (p = 0.0029); BC and PET (p = 0.0141). Surprisingly, considering the low platelet consumption, the complement activation parameters (sC3a and sC5b-9) were much higher for BC, as compared with the other materials for both 4 and 6 mm tubes.
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| 318. |
- Finnveden, Göran, et al.
(author)
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Evaluation of integration of sustainable development in higher education in Sweden
- 2020
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In: International Journal of Sustainability in Higher Education. - : Emerald Group Publishing Limited. - 1467-6370 .- 1758-6739. ; 21:4, s. 685-698
-
Journal article (peer-reviewed)abstract
- Purpose Since 2006, higher education institutions (HEIs) in Sweden, should according to the Higher Education Act, promote sustainable development (SD). In 2016, the Swedish Government asked the Swedish higher education authority to evaluate how this study is proceeding. The authority chose to focus on education. This paper aims to produce a report on this evaluation. Design/methodology/approach All 47 HEIs in Sweden were asked to write a self-evaluation report based on certain evaluation criteria. A panel was appointed consisting of academics and representatives for students and working life. The panel wrote an evaluation of each HEI, a report on general findings and recommendations, and gave an overall judgement of each HEI in two classes as follows: the HEI has well-developed processes for integration of SD in education or the HEI needs to develop their processes. Findings Overall, a mixed picture developed. Most HEIs could give examples of programmes or courses where SD was integrated. However, less than half of the HEIs had overarching goals for integration of SD in education or had a systematic follow-up of these goals. Even fewer worked specifically with pedagogy and didactics, teaching and learning methods and environments, sustainability competences or other characters of education for SD. Overall, only 12 out of 47 got a higher judgement. Originality/value This is a unique study in which all HEIs in a country are evaluated. This provides unique possibilities for identifying success factors and barriers. The importance of the leadership of the HEIs became clear.
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| 319. |
- Flovik, Vegard, et al.
(author)
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Tailoring the magnetodynamic properties of nanomagnets using magnetocrystalline and shape anisotropies
- 2015
-
In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X .- 2469-9950 .- 2469-9969. ; 92:10
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Journal article (peer-reviewed)abstract
- Magnetodynamical properties of nanomagnets are affected by the demagnetizing fields created by the same nanoelements. In addition, magnetocrystalline anisotropy produces an effective field that also contributes to the spin dynamics. We show how the dimensions of magnetic elements can be used to balance crystalline and shape anisotropies, and that this can be used to tailor the magnetodynamic properties. We study ferromagnetic ellipses patterned from a 10-nm-thick epitaxial Fe film with dimensions ranging from 50x150 to 150x450 nm. The study combines ferromagnetic resonance (FMR) spectroscopy with analytical calculations and micromagnetic simulations, and proves that the dynamical properties can be effectively controlled by changing the size of the nanomagnets. We also show how edge defects in the samples influence the magnetization dynamics. Dynamical edge modes localized along the sample edges are strongly influenced by edge defects, and this needs to be taken into account in understanding the full FMR spectrum.
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| 320. |
- Fontana, Enrico, et al.
(author)
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Nominated procurement and the indirect control of nominated sub-suppliers: Evidence from the Sri Lankan apparel supply chain
- 2021
-
In: Journal of Business Research. - : Elsevier BV. - 0148-2963 .- 1873-7978. ; 127, s. 179-192
-
Journal article (peer-reviewed)abstract
- This article describes and discusses nominated procurement as a means through which buyers select sub-suppliers to achieve sustainability compliance upstream in emerging economies' supply chains. Hence, it critically examines the ways buyers articulate nominated procurement and the unfolding supply chain consequences. Based on in-depth interviews and fieldwork in the Sri Lankan apparel supply chain, the findings indicate that buyers accomplish sustainability compliance among their sub-suppliers while prioritizing their own business agenda. In doing so, however, buyers perpetuate “suboptimal compliance” of raw material suppliers and “sandwiching” of direct suppliers as harmful consequences on the supply chain. These consequences link theoretically with commercial, geographical, compliance and extended-compliance pressure. This article contributes to the advancement of the Sustainable Supply Chain Management literature by theorizing about nominated procurement, direct and indirect pressure, and pointing to the supply chain consequences beyond achievements in sustainability compliance.
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