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The use of clinical...
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women.
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Kanis, J A (author)
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- Odén, Anders, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Johnell, Olof (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Johansson, Helena, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg
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De Laet, C (author)
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Brown, J (author)
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Burckhardt, P (author)
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Cooper, C (author)
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Christiansen, C (author)
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Cummings, S (author)
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Eisman, J A (author)
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Fujiwara, S (author)
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Glüer, C (author)
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Goltzman, D (author)
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Hans, D (author)
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Krieg, M-A (author)
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La Croix, A (author)
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McCloskey, E (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg
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Melton, L J (author)
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Pols, H (author)
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Reeve, J (author)
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Sanders, K (author)
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Schott, A-M (author)
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Silman, A (author)
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Torgerson, D (author)
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van Staa, T (author)
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Watts, N B (author)
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Yoshimura, N (author)
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(creator_code:org_t)
- 2007-02-24
- 2007
- English.
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In: Osteoporosis international. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 18:8, s. 1033-46
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Abstract
Subject headings
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- SUMMARY: BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. INTRODUCTION AND HYPOTHESES: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. METHODS: Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). RESULTS: CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR = 1.4/SD) and was not markedly increased by the combination (GR = 1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. CONCLUSIONS: The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Age Factors
- Aged
- Aged
- 80 and over
- Area Under Curve
- Bone Density
- physiology
- Female
- Fractures
- Spontaneous
- etiology
- physiopathology
- Hip Fractures
- etiology
- physiopathology
- Humans
- Male
- Middle Aged
- Osteoporosis
- complications
- physiopathology
- Osteoporosis
- Postmenopausal
- etiology
- physiopathology
- Risk Assessment
- methods
- Risk Factors
- physiology
- fracture
- osteoporotic
- meta-analysis
- bone mineral density
- hip fracture
- risk assessment
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kanis, J A
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Odén, Anders, 19 ...
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Johnell, Olof
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Johansson, Helen ...
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De Laet, C
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Brown, J
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show more...
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Burckhardt, P
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Cooper, C
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Christiansen, C
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Cummings, S
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Eisman, J A
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Fujiwara, S
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Glüer, C
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Goltzman, D
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Hans, D
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Krieg, M-A
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La Croix, A
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McCloskey, E
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Mellström, Dan, ...
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Melton, L J
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Pols, H
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Reeve, J
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Sanders, K
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Schott, A-M
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Silman, A
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Torgerson, D
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van Staa, T
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Watts, N B
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Yoshimura, N
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Osteoporosis int ...
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Lund University