| 1. |
- Dahlgren, E., et al.
(författare)
-
A screening study of relationships among concentrations of algal toxins, PFAS, thiamine deficiency and biomarkers in the European flounder from the southern Baltic Sea
- 2022
-
Ingår i: Regional Studies in Marine Science. - : Elsevier BV. - 2352-4855. ; 53
-
Tidskriftsartikel (refereegranskat)abstract
- In the disturbed Baltic Sea ecosystem, several animal species display failing health related to exposure to toxic compounds, reduced energy metabolism and immune system disorders. In order to investigate possible associations between fish health and exposure to chemicals affecting the energy metabolism and immune defence, the levels of algal toxins (bromophenols, hydroxylated polybrominated diphenyl ethers and nodularin), perfluorinated alkyl substances (PFAS) and thiamine (vitamin B1) were determined in European flounder (Platichthys flesus). Several biomarkers indicating health status were examined in the fish, including ethoxyresorufin-O-deethylase (EROD), and activities of glutathione reductase, glutathione S-transferase and catalase, in addition to a large set of blood variables. The fish were collected from Hanobukten in the south-western parts of the Baltic Sea in late August 2018. Regression analyses of algal toxins, PFAS and thiamine concentration displayed several significant associations with biomarkers associated with detoxification and liver function, immune system function and blood status of the fish. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
| 2. |
- Gustafsson, Johan, et al.
(författare)
-
Adult female European perch (Perca fluviatilis) from the Baltic Sea show no evidence of thiamine deficiency
- 2021
-
Ingår i: Journal of Sea Research. - : Elsevier BV. - 1385-1101 .- 1873-1414. ; 174
-
Tidskriftsartikel (refereegranskat)abstract
- Deficiency of thiamine (vitamin B1) has been demonstrated in several species in the northern hemisphere and is suggested as a cause for declining populations. European perch from the Baltic Sea show negative temporal trends for several health biomarkers and poor recruitment of unknown cause. In this study, thiamine status of perch liver from the Baltic Sea was studied with emphasis on seasonal variation. During spring the thiamine concentration increased, reached a higher level during the summer and then decreased again during autumn. Despite this variation the thiamine concentration was always sufficient in the perch liver. These results indicate that direct thiamine deficiency is an unlikely explanation for the health effects observed in adult female perch from the Baltic Sea.
|
|
| 3. |
- Gustafsson, Johan, et al.
(författare)
-
Correlating seasonal changes of naturally produced brominated compounds to biomarkers in perch from the Baltic Sea
- 2021
-
Ingår i: Aquatic Toxicology. - : Elsevier BV. - 0166-445X .- 1879-1514. ; 240
-
Tidskriftsartikel (refereegranskat)abstract
- Hydroxylated polybrominated diphenyl ethers (OH-PBDEs), naturally produced by algae and cyanobacteria in the Baltic Sea, are potent disrupters of energy metabolism as well as endocrine disruptors and neurotoxins. In this study, European perch (Perca fluviatilis) from the Baltic Sea were sampled from May until October. OH-PBDEs and ten biomarkers were measured in each individual (n = 84 over 18 sampling time points) to study potential correlations between exposure to OH-PBDEs and changes in biomarkers. Several biomarkers showed significant non-linear seasonal variation. In the perch, ethoxyresorufin-O-deethylase (EROD) activity, plasma lactate concentration, and plasma glucose concentration showed a significant positive log-linear correlation with OH-PBDEs, whereas lipid percentage and liver somatic index showed a significant negative log-linear correlation with OH-PBDEs. These results strengthen the concern that OH-PBDEs could cause negative health effects for fish in the Baltic Sea.
|
|
| 4. |
- Pettersson, M., et al.
(författare)
-
Fish bile used to detect estrogenic substances in treated sewage water
- 2006
-
Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 366:1, s. 174-186
-
Tidskriftsartikel (refereegranskat)abstract
- Endocrine disrupting effects on fish associated with sewage treatment effluents have been demonstrated in several studies. To investigate if the effluents from two modem Swedish sewage treatment plants contained estrogenic substances, juvenile rainbow trout were exposed to sewage water before and after the last treatment step which is a sand filter. As a biomarker for estrogenic effect, vitellogenin was analysed in the blood plasma of the exposed fish. To identify substances possibly responsible for the effect, bile fluid from the exposed fish were analysed with GUMS. Elevated levels of vitellogenin were only seen in the fish exposed at one of the sewage treatment plants, the one with shorter residence time in the biological treatment steps, which suggests that the residence time is of importance for the ability to reduce the amount of estrogenic substances in the sewage water. The highest elevation of vitellogenin was seen in the fish exposed to water before the sand filter, which indicates that the sand filter contributes to further reduction of estrogenic substances in the sewage water. In bile from the same group of fish, considerably higher concentrations of estrone, bisphenol A and 4-nonylphenol (4.0 mu g/g bile, 23 mu g/g bile and 24 mu g/g bile, respectively) were observed compared to bile from control fish (< 0.04 mu g/g bile, 0.21 mu g/g bile, and 3.5 mu g/g bile, respectively). The more potent steroidal estrogens were suggested to be major contributors to the observed estrogenic effect, although xenoestrogens were detected at higher concentrations in the bile fluid. (c) 2005 Elsevier B.V. All rights reserved.
|
|
