| 51. |
- Almstedt, Elin, 1988-, et al.
(författare)
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Integrative discovery of treatments for high-risk neuroblastoma
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobanks, pharmacological databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.
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| 52. |
- Alsaody, Seidon, 1986, et al.
(författare)
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Lie bialgebras, fields of cohomological dimension at most 2 and Hilbert's Seventeenth Problem
- 2017
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Ingår i: Journal of Algebra. - : Elsevier BV. - 0021-8693 .- 1090-266X. ; 476, s. 368-394
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Tidskriftsartikel (refereegranskat)abstract
- © 2016 Elsevier Inc.We investigate Lie bialgebra structures on simple Lie algebras of non-split type A. It turns out that there are several classes of such Lie bialgebra structures, and it is possible to classify some of them. The classification is obtained using Belavin–Drinfeld cohomology sets, which are introduced in the paper. Our description is particularly detailed over fields of cohomological dimension at most two, and is related to quaternion algebras and the Brauer group. We then extend the results to certain rational function fields over real closed fields via Pfister's theory of quadratic forms and his solution to Hilbert's Seventeenth Problem.
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| 53. |
- Amombo Noa, Francoise Mystere, 1988, et al.
(författare)
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A unified topology approach to dot-, rod-, and sheet-MOFs
- 2021
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Ingår i: Chem. - : Elsevier BV. - 2451-9294 .- 2451-9308. ; 7:9, s. 2491-2512
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Tidskriftsartikel (refereegranskat)abstract
- Metal-organic frameworks made from multi-metal-ion units in the shape of clusters and rods (termed dot-MOFs and rod-MOFs) are well known. Here, we introduce MOFs with multi-metallic units in the form of sheets-sheet-MOFs. We show exemplars of all three types of units based on structures containing Y3+, Ce3+, or Gd3+ linked by benzene1,2,4,5-tetracarboxylate to give crystals of a dot-MOF in H2NMe2[Y(b-tec)(H2O)] CTH-14, a sheet-MOF in [Ce-3(btec)(Hbtec)(OAc)(HCO2)] CTH-15, and a rod-MOF in 4,4'-azopyridinium[Gd-2(btec)(2)] CTH-16. Cyclic voltammetry shows that CTH-15 stabilizes Ce(IV). Given the fact that sheet-MOFs represent an intellectual advance in the evolution of MOFs, a unified approach is proposed for the topological classification of dot-, rod-, and sheet-MOFs. It is suggested that the stability ofMOFs follow in the trend dot < rod < sheet. For CTH-14-16, the sheet- and the rod-MOF have higher thermal stability. We suggest sheet-MOFs as an additional strategy for making robust MOFs.
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| 54. |
- Amombo Noa, Francoise Mystere, 1988, et al.
(författare)
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Chiral Lanthanum Metal-Organic Framework with Gated CO2 Sorption and Concerted Framework Flexibility br
- 2022
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 144:19, s. 8725-8733
-
Tidskriftsartikel (refereegranskat)abstract
- A metal-organic framework (MOF)CTH-17based on lanthanum-(III) and the conformationally chiral linker 1,2,3,4,5,6-hexakis(4-carboxyphenyl)-benzene, cpb6-: [La2(cpb)]middot1.5dmf was prepared by the solvothermal method indimethylformamide (dmf) and characterized by variable-temperature X-raypowder diffraction (VTPXRD), variable-temperature X-ray single-crystal diffrac-tion (SCXRD), and thermogravimetric analysis (TGA).CTH-17is a rod-MOFwith new topologyoch. It has high-temperature stability with Sohncke spacegroupsP6122/P6522 at 90 K andP622 at 300 and 500 K, all phases characterizedwith SCXRD and at 293 K also with three-dimensional (3D) electron diffraction. VTPXRD indicates a third phase appearing after620 K and stable up to 770 K. Gas sorption isotherms with N2indicate a modest surface area of 231 m2g-1forCTH-17, roughly inagreement with the crystal structure. Carbon dioxide sorption reveals a gate-opening effect ofCTH-17where the structure opens upwhen the loading of CO2reaches approximately similar to 0.45 mmol g-1or 1 molecule per unit cell. Based on the SCXRD data, this isinterpreted asflexibility based on the concerted movements of the propeller-like hexatopic cpb linkers, the movementintramolecularly transmitted by the pi-pi stacking of the cpb linkers and helped by thefluidity of the LaO6coordination sphere. Thiswas corroborated by density functional theory (DFT) calculations yielding the chiral phase (P622) as the energy minimum and acompletely racemic phase (P6/mmm), with symmetric cpb linkers representing a saddle point in a racemization process
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| 55. |
- Amombo Noa, Francoise Mystere, 1988, et al.
(författare)
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Metal-Organic Frameworks with Hexakis(4-carboxyphenyl)benzene: Extensions to Reticular Chemistry and Introducing Foldable Nets
- 2020
-
Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 142:20, s. 9471-9481
-
Tidskriftsartikel (refereegranskat)abstract
- Nine metal-organic frameworks have been prepared with the hexagon-shaped linker 1,2,3,4,5,6-hexakis(4-carboxyphenyl)-benzene (H(6)cpb) by solvothermal reactions in dimethylformamide (dmf) or dimethylacetamide (dmac) with acetic acid or formic acid as modulators: [Bi-2(cpb)(acetato)(2)(dmf)(2)]center dot 2dmf CTH-6 forms a rtl-net; 2(H2NMe2)[Cu-2(cpb)] CTH-7 forms a kgd-net; [Fe-4(cpb)-(acetato)(2)(dmf)(4)] CTH-8 and [Co-4(cpb)(acetato)(2)(dmf)(4)] CTH-9 are isostructural and form yav-nets; 2(HNEt3)[Fe-2(cpb)] CTH-10 and the two polymorphs of 2(H2NMe2)[Zn-2(cpb)]center dot 1.5dmac, Zn-MOF-888 and CTH-11, show kgd-nets; [Cu-2(cpb)-(acetato)(2)(dmf)(2)]center dot 2dmf, CTH-12, forms a mixed coordination and hydrogen-bonded sql-net; and 2(H2NMe2)[Zn-2(cpb)] CTH-13, a similarly mixed yav-net. Surface area values (Brunauer-Emmett-Teller, BET) range from 34 m(2) g(-1) for CTH-12 to 303 m(2) g(-1) for CTH-9 for samples activated at 120 degrees C in dynamic vacuum. All compounds show normal (10-fold higher) molar CO2 versus N-2 uptake at 298 K, except the 19-fold CO2 uptake for CTH-12 containing Cu(II) dinuclear paddle-wheels. We also show how perfect hexagons and triangles can combine to a new 3D topology laf, a model of which gave us the idea of foldable network topologies, as the laf-net can fold into a 2D form while retaining the local geometry around each vertex. Other foldable nets identified are cds, cds-a, ths, sqc163, clh, jem, and tfc covering the basic polygons and their combinations. The impact of this concept on "breathing" MOFs is discussed. I-2 sorption, both from gas phase and from MeOH solution, into CTH-7 were studied by time of flight secondary ion mass spectrometry (ToF-SIMS) on dried crystals. I-2 was shown to have penetrated the crystals, as layers were consecutively peeled off by the ion beam. We suggest ToF-SIMS to be a method for studying sorption depth profiles of MOFs.
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| 56. |
- amundsen, silja, et al.
(författare)
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A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families.
- 2007
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Ingår i: European Journal of Human genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 15:9, s. 980-987
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Tidskriftsartikel (refereegranskat)abstract
- Celiac disease (CD) is a gluten-induced enteropathy, which results from the interplay between environmental and genetic factors. There is a strong human leukocyte antigen (HLA) association with the disease, and HLA-DQ alleles represent a major genetic risk factor. In addition to HLA-DQ, non-HLA genes appear to be crucial for CD development. Chromosomal region 5q31–33 has demonstrated linkage with CD in several genome-wide studies, including in our Swedish/Norwegian cohort. In a European meta-analysis 5q31–33 was the only region that reached a genome-wide level of significance except for the HLA region. To identify the genetic variant(s) responsible for this linkage signal, we performed a comprehensive single nucleotide polymorphism (SNP) association screen in 97 Swedish/Norwegian multiplex families who demonstrate linkage to the region. We selected tag SNPs from a 16 Mb region representing the 95% confidence interval of the linkage peak. A total of 1404 SNPs were used for the association analysis. We identified several regions with SNPs demonstrating moderate single- or multipoint associations. However, the isolated association signals appeared insufficient to account for the linkage signal seen in our cohort. Collective effects of multiple risk genes within the region, incomplete genetic coverage or effects related to copy number variation are possible explanations for our findings.
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| 57. |
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| 58. |
- Anderson, Louise, 1989, et al.
(författare)
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Quantum Phase Transitions in Mass-Deformed ABJM Matrix Model
- 2014
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; 1409:9, s. Art. no. 021-20
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Tidskriftsartikel (refereegranskat)abstract
- When mass-deformed ABJM theory is considered on S(3), the partition function of the theory localises and is given by a matrix model. We solve this model at large-N in the decompactification limit, where the radius of the three-sphere is taken to infinity. In this limit, the theory exhibits a rich phase structure with an infinite number of third-order quantum phase transitions accumulating at strong coupling.
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| 59. |
- Andersson, David, et al.
(författare)
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Att försvara ett patent: Den lilla aktörens utmaningar i patenttvister
- 2023
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Ingår i: Management of Innovation and Technology. - : Stiftelsen IMIT. - 2001-208X .- 2002-8873. ; 2023:1, s. 3-5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Patenttvister i domstol utgör en viktig del av innovationssystemet, som möjliggör för uppfinnare och innovatörer att skydda sina uppfinningar. Det finns dock indikationer, både från forskning och praktik, på att mindre aktörer som småföretagare och uppfinnare stöter på oproportionerliga hinder när de gäller patentintrång och de juridiska processer som det innebär. Artikeln fokuserar på hur och varför dessa problem uppstår och pekar på möjliga förbättringar.
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| 60. |
- Andersson, Erik, et al.
(författare)
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Ambio fit for the 2020s
- 2022
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Ingår i: Ambio. - : Springer Nature. - 0044-7447 .- 1654-7209. ; 51:5, s. 1091-1093
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Tidskriftsartikel (refereegranskat)
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