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Sökning: swepub > Umeå universitet > Refereegranskat > (2000-2004) > Tidskriftsartikel

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3531.
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3532.
  • Svensson, Anette, et al. (författare)
  • Preparation of fluorinated linkers : Use of F-19 NMR spectroscopy to establish conditions for solid-phase synthesis of pilicide libraries
  • 2000
  • Ingår i: Journal of Combinatorial Chemistry. - : American Chemical Society (ACS). - 1520-4766 .- 1520-4774. ; 2:736-48
  • Tidskriftsartikel (refereegranskat)abstract
    • Three fluorinated linkers which are analogues of linkers commonly used in solid-phase peptide synthesis have been prepared. One of the linkers was used in combination with gel-phase F-19 NMR spectroscopy to develop conditions for solid-phase synthesis of two libraries of pilicides, i.e. compounds designed to inhibit assembly of adhesive pill in uropathogenic Escherichia coli. Attachment to and cleavage from the linker could be monitored based on the chemical shift of the fluorine atom of the linker. In addition, use of the linker as internal standard allowed quantification and optimization of reactions occurring further away from the linker when fluorinated building blocks were employed. Importantly, high-quality F-19 NMR spectra were obtained for compounds linked to a TentaGel resin in a standard NMR tube using an ordinary NMR instrument.
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3533.
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3534.
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3535.
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3536.
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3537.
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3538.
  • Syeda, Baquer M., et al. (författare)
  • 9-BBN as a convenient protecting group in functionalisation of hydroxylysine
  • 2004
  • Ingår i: Tetrahedron. - : Elsevier BV. - 0040-4020. ; 60:26, s. 5571-5
  • Tidskriftsartikel (refereegranskat)abstract
    • 9-BBN was used for regioselective protection of the α-amino and α-carboxyl groups of (5R)-5-hydroxy--lysine. The resulting 9-BBN complex was then employed in transformations such as N-Cbz protection, azido transfer, O-glycosylation, and O-silylation. Further manipulations led to improved methods for preparation of hydroxylysine and galactosylated hydroxylysine building blocks, suitable for direct use in peptide synthesis under standard Fmoc conditions.
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3539.
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3540.
  • Sze, C C, et al. (författare)
  • In vivo and in vitro effects of integration host factor at the DmpR-regulated sigma(54)-dependent Po promoter.
  • 2001
  • Ingår i: Journal of Bacteriology. - 0021-9193 .- 1098-5530. ; 183:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Transcription from the Pseudomonas CF600-derived sigma(54)-dependent promoter Po is controlled by the aromatic-responsive activator DmpR. Here we examine the mechanism(s) by which integration host factor (IHF) stimulates DmpR-activated transcriptional output of the Po promoter both in vivo and in vitro. In vivo, the Po promoter exhibits characteristics that typify many sigma(54)-dependent promoters, namely, a phasing-dependent tolerance with respect to the distance from the regulator binding sites to the distally located RNA polymerase binding site, and a strong dependence on IHF for optimal promoter output. IHF is shown to affect transcription via structural repercussions mediated through binding to a single DNA signature located between the regulator and RNA polymerase binding sites. In vitro, using DNA templates that lack the regulator binding sites and thus bypass a role of IHF in facilitating physical interaction between the regulator and the transcriptional apparatus, IHF still mediates a DNA binding-dependent stimulation of Po transcription. This stimulatory effect is shown to be independent of previously described mechanisms for the effects of IHF at sigma(54) promoters such as aiding binding of the regulator or recruitment of sigma(54)-RNA polymerase via UP element-like DNA. The effect of IHF could be traced to promotion and/or stabilization of open complexes within the nucleoprotein complex that may involve an A+T-rich region of the IHF binding site and promoter-upstream DNA. Mechanistic implications are discussed in the context of a model in which IHF binding results in transduction of DNA instability from an A+T-rich region to the melt region of the promoter.
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