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Sökning: WFRF:(Li X.) > Handelshögskolan i Stockholm

  • Resultat 1-4 av 4
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1.
  • Clark, DW, et al. (författare)
  • Associations of autozygosity with a broad range of human phenotypes
  • 2019
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
  • Tidskriftsartikel (refereegranskat)abstract
    • In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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3.
  • Li, Erica X. N., et al. (författare)
  • Inventory behavior and financial constraints: Theory and evidence
  • 2019
  • Ingår i: Review of Financial Studies. - : Oxford University Press (OUP): Policy F - Oxford Open Option D. - 0893-9454 .- 1465-7368. ; 32:3, s. 1188-1233
  • Tidskriftsartikel (refereegranskat)abstract
    • We model the interaction of financial constraints, capacity constraints, and the response of production and inventory to cost and demand shocks. The model predicts that in response to favorable shocks, financially constrained firms are unable to build inventory as rapidly as are unconstrained firms. However, because the favorable shocks gradually ease the financial constraints, constrained firms continue to build inventory and eventually carry surplus inventory (relative to unconstrained firms) to unfavorable states. This allows them to deplete inventory more aggressively in response to unfavorable shocks. Our empirical evidence provides broad support for the model's predictions. © The Author(s) 2018. Published by Oxford University Press on behalf of The Society for Financial Studies.
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4.
  • Yan, Dong, et al. (författare)
  • Inventory Behavior and Financial Constraints: Theory and Evidence
  • 2014
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Financially constrained firms hold more inventory than do financially unconstrained firms and also show more volatility in inventory holdings. To understand why, we model the interaction of financial constraints, capacity constraints, and the response of production and inventory to cost shocks. We develop several implications as to how financial constraints affect the inventory response to cost shocks of constrained firms relative to unconstrained firms, which cannot be derived from any of a host of other ways in which two groups of firms are differentiated in our model. We find consistent results when we take these implications to the real data.
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  • Resultat 1-4 av 4

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