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- Klintenberg, Patrik, et al.
(författare)
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INVESTMENT MEMO ABOWE PILOT B SWEDEN
- 2014
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Rapport (refereegranskat)abstract
- This report is one output of ABOWE project (Implementing Advanced Concepts for Biological Utilization of Waste), which belongs to EU Baltic Sea Region Programme 2007-2013. ABOWE works with two promising technologies to unlock investments. Two mobile pilot plants have been built and will be tested in several Baltic Sea regions. These pilots are based on a novel biorefinery concept from Finnoflag Oy, Finland, known as Pilot A as well as a German dry fermentation process, known as Pilot B. The pilots form the basis for compilation of Investment Memos and organizing Investor Events. Also a regional model is used to evaluate the new processes’ economic and climatic impacts in each region. The desired outcome from ABOWE is implementer/investor driven continuation projects targeting full-scaleplant investments of the two technologies.The purpose of ABOWE Work Package 2 is to gather and communicate information from many aspects of technologies which are piloted with Pilot A and Pilot B to support investment decisions for full scale plants. In practice, a demo full scaleplant would be needed in order to convince the commercial investors and implementers to full scale plants. This means that ABOWE provides with profound information and a step forward regarding the two technologies. After ABOWE, the technology will need development for full-scale, and the feasibility will need further analysis. An implementer and investor should be found to conduct development further towards full-scale demo plant.
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| 6. |
- Buck, Dietrich, 1990-, et al.
(författare)
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Production and In-Plane Compression Mechanics of Alternatively Angled Layered Cross-Laminated Timber
- 2018
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Ingår i: BioResources. - : University of North Carolina Press. - 1930-2126 .- 1930-2126. ; 13:2, s. 4029-4045
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Tidskriftsartikel (refereegranskat)abstract
- Increasing awareness of sustainable building materials has led to interest in enhancing the structural performance of engineered wood products. This paper reports mechanical properties of cross-laminated timber (CLT) panels constructed with layers angled in an alternative configuration on a modified industrial CLT production line. Timber lamellae were adhesively bonded together in a single-step press procedure to form CLT panels. Transverse layers were laid at an angle of 45°, instead of the conventional 90° angle with respect to the longitudinal layers’ 0° angle. Tests were carried out on 20 five-layered CLT panels divided into two matched groups with either a 45° or a 90° configuration; an in-plane uniaxial compressive loading was applied in the principal orientation of the panels. These tests showed that the 45°-configured panels had a 30% higher compression stiffness and a 15% higher compression strength than the 90° configuration. The results also revealed that the 45°-configured CLT can be industrially produced without using more material than is required for conventional CLT 90° panels. In addition, the design possibility that the 45°-configured CLT can carry a given load while using less material also suggests that it is possible to use CLT in a wider range of structural applications.
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| 7. |
- Capala, Jacek, et al.
(författare)
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Clinical BNCT studies in Sweden
- 2002
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Ingår i: Research and development in neutron capture therapy. - : Monduzzi Editore Print. ; , s. 1101-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Carmignac, Virginie, et al.
(författare)
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Proteasome Inhibition Improves the Muscle of Laminin {alpha}2 Chain Deficient Mice.
- 2011
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 20:3, s. 541-552
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Tidskriftsartikel (refereegranskat)abstract
- Muscle atrophy, a significant characteristic of congenital muscular dystrophy with laminin α2 chain deficiency (also known as MDC1A), occurs by a change in the normal balance between protein synthesis and protein degradation. The ubiquitin-proteasome system plays a key role in protein degradation in skeletal muscle cells. In order to identify new targets for drug therapy against MDC1A, we have investigated whether increased proteasomal degradation is a feature of MDC1A. Using the generated dy(3K)/dy(3K) mutant mouse model of MDC1A, we studied the expression of members of the ubiquitin-proteasome pathway in laminin α2 chain deficient muscle and we treated dy(3K)/dy(3K) mice with the proteasome inhibitor MG-132. We show that members of the ubiquitin-proteasome system are upregulated and that the global ubiquitination of proteins is raised in dystrophic limb muscles. Also, phosphorylation of Akt is diminished in diseased muscles. Importantly, proteasome inhibition significantly improves the dystrophic dy(3K)/dy(3K) phenotype. Specifically, treatment with MG-132 increases lifespan, enhances locomotive activity, enlarges muscle fiber diameter, reduces fibrosis, restores Akt phosphorylation and decreases apoptosis. These studies promote better understanding of the disease process in mice and could lead to a drug therapy for MDC1A patients.
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| 10. |
- Chaillou, Thomas, 1985-, et al.
(författare)
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Ambient hypoxia enhances the muscle-mass loss after extensive injury
- 2011
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Ingår i: The FASEB Journal. - : Federation of American Society of Experimental Biology (FASEB). - 0892-6638 .- 1530-6860. ; 25:1 Suppl.
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the effect of ambient hypoxia on the main intracellular pathways involved in muscle regeneration. Left soleus muscles of female rats were degenerated by notexin injection before exposure to either normoxia (N) or ambient hypoxia (H) (10% O2) during 3, 7, 14 and 28 days (d). The expected muscle-mass loss of injured muscles was higher in H than in N rats at d3 and d7, whereas the recovery of muscle mass was similar in H and N rats at d28. The mammalian target of rapamycin (mTOR) activity, assessed from both eIF-4E binding protein (4E-BP1) and P70S6K phosphorylation, was markedly increased during the early period of regeneration, but remained two-fold lower in H than in N groups at d3. The hypoxia-induced alteration of mTOR activity, independently of Akt, was associated with an activation of AMP-activated kinase (AMPK) at d3. In contrast, REDD1, another negative regulator of mTOR, was markedly activated by H at d14 and d28 in intact muscles, but was blunted during the first days of regeneration (d3–7), independently of H. Taken together, we show for the first time, that hypoxia enhances the muscle-mass loss after extensive injury. This could be due to a specific impairment of mTOR activation during muscle regeneration, independently of Akt, at least partly related to AMPK activation, without detectable effect of REDD1.
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