| 1. |
- Adner, Mikael, et al.
(författare)
-
Contractile endothelin-B (ETB) receptors in human small bronchi
- 1996
-
Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 9:2, s. 351-355
-
Tidskriftsartikel (refereegranskat)abstract
- Endothelins (ETs) are a family of novel regulatory peptides and various lines of evidence suggest an important role for ETs in regulating pulmonary function. Two receptors for endothelin, ETA and ETB, have been found in the human lung, and according to recent studies a non-ETA receptor seems to mediate the contraction of large sized human bronchi. Several studies have emphasized the importance of small bronchi in the pathogenesis of airway disease. In the present paper, improved methodology was used which enables in vitro studies of small human bronchi down to a diameter of 0.5-1.0 mm. Using the new methodology we have tried to further characterize this receptor. Small bronchi from the distal parts of the bronchial tree were obtained from pulmonary tissue removed from 15 patients with lung cancer. They were dissected and cut into ring segments, in which isometric tension was recorded. ET-1, ET-2 and ET-3 elicited strong concentration-dependent contractions of the human small bronchus. Basically, the three peptides were equipotent with about the same maximal response. Upon reapplication, they all showed the same tachyphylaxis pattern, reaching half the initial contraction. Comparative analysis of IRL 1620, a selective ETB receptor agonist, revealed that the effect of the ETB agonist was, in all respects, similar to the responses induced by the ETs. PD 145065, a combined ETA/ETB receptor antagonist competitively inhibited the contractions induced by IRL 1620, whereas FR139317, a selective ETA receptor antagonist, was without effect. In conclusion, the present study shows that accurate measurements can be made in vitro on small human bronchi and all present data are in favour of an ETB receptor mediating endothelin-induced contraction of human bronchi smaller than 1.0 mm.
|
|
| 2. |
- Ahlén, Anders, et al.
(författare)
-
Wireless IP - a new PCC project
- 1999
-
Ingår i: Proc. PCC Workshop, Lund, Sweden. ; , s. 100-101
-
Konferensbidrag (refereegranskat)
|
|
| 3. |
|
|
| 4. |
- Ottosson, Mikael
(författare)
-
Sohlberg och surdegen : sociala relationer på Kosta glasbruk 1820-1880
- 1999
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis focuses on the circumstances at the glassworks of Kosta during the years 1820-1880. The glassworks founded there in 1742 was but one of many small Swedish rural works. Throughout the period in question, the glassworks can be seen as a small-scale factory with about 80 households directly engaged in industrial production. Like the rest of the glass industry, the glassworks at Kosta developed from the production of glass for a principally local market to that of mass production. I have contextualised the developments at Kosta by applying a perspective where certain societal changes were decisive. I have assumed that the most important process during 1820-1880 was the shift in economy towards capitalism. It was this change in the relations of production that proved crucial at Kosta. The object of the study has been mainly to investigate the relation between wage earners and the formation of group- or class-identity during the early industrial period in order to try to capture the pre-union formation of group identity. The results of the study may be summarised in three main points. First, a study of the changes of the labour process at Kosta sheds new light upon how these changes were carried out. Second, the discussion of paternalism as a concept gives a new view of the rural industrial communities. Thirdly, such a study stresses how social patterns of identity changed with the new organisation of labour.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
