| 1041. |
- Rein, Claus
(författare)
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The pressure-temperature dependence of the electrical resistance of Zeranin in the temperature range 160-370 K and at pressures up to 1 GPa
- 1993
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Ingår i: Measurement science and technology. - : Institute of Physics Publishing (IOPP). - 0957-0233 .- 1361-6501. ; 4:11, s. 1194-1200
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Tidskriftsartikel (refereegranskat)abstract
- Several Zeranin wire coils of different design are described. Two of them of the self-supporting type have been used for the determination of the temperature dependence of the electrical resistance between about 160 and 370 K at five different pressures up to 1 GPa. It was found that the temperature dependence of the electrical resistance of Zeranin at high pressure is only slightly different from the normal pressure behaviour. This property favors Zeranin compared to other materials for the manufacture of resistance pressure gauges, which are to be used over a large temperature range.
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| 1042. |
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| 1043. |
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| 1044. |
- Riklund, Katrine, et al.
(författare)
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Experimental radioimmunotherapy of HeLa tumours in nude mice with 131I-labeled monoclonal antibodies.
- 1990
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 10:2A, s. 379-84
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Tidskriftsartikel (refereegranskat)abstract
- The radioimmunotherapeutic potential of 131I-labeled monoclonal antibodies was investigated in 36 nude mice (BALB/c nu/nu) inoculated s.c. with the HeLa Hep 2 human adenocarcinoma cell line. The membrane bound tumour associated antigen placental alkaline phosphatase and several intracellular cytokeratins served as targets for the antibodies. The specific radioactivity in each organ was determined after i.p. injection of the 131I-labeled antibodies (0.2-0.3 mg, approximately 15 MBq/animal), and high localization to the tumours was seen. Significant growth inhibition was observed after injection of the radiolabeled monoclonal antibody H7 against the placental alkaline phosphatase, which reduced the tumour growth to only 12% during a 3 week period compared to a growth of more than 100% for the controls. Animal weight losses were seen. Synthesis of endogenous antibodies to the target antigens was found to be significant. Morphometric evaluation of the relations between stroma, tumour cells and necrotic areas in the tumours after radioimmunotherapy demonstrated a significant increase of the mean relative connective tissue volume and a significant decreased mean of relative volume of tumour cells in the group treated with iodinated antiplacental alkaline phosphatase antibody. This therapeutic principle is encouraging and may offer new possibilities for future treatment of some malignant diseases.
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| 1045. |
- Riklund, Katrine, et al.
(författare)
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Inhibition of growth of HeLa cell tumours in nude mice by 125I-labeled anticytokeratin and antiPLAP monoclonal antibodies.
- 1991
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 11:2, s. 555-560
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Tidskriftsartikel (refereegranskat)abstract
- The radiommunotherapeutic potential of 125I-labeled monoclonal antibodies was investigated in 48 nude mice (BALB/c, nu/nu) inoculated s.c. with the HeLa Hep 2 human adenocarcinoma cell line. This isotope, 125I, which is not commonly used for therapeutic purposes caused significant decrease in tumour growth from day 10 to day 42, when coupled to monoclonal antibodies directed against placental alkaline phosphatase (H7) or cytokeratins (TS1). The average growth rate was approximately 50-60% of that observed in the untreated control group after 42 days. The specific radioactivity in each organ 42 days after injection of radiolabeled monoclonal antibodies, indicated that these target antigens retain significant amounts of radiolabeled antibody in the tumours for at least 6 weeks after injection. No weight loss was seen in the animals during this experiment. By use of autoradiographic techniques, the labeled monoclonal antibodies were visualized deep in tumours in characteristic patterns representative of viable tumour cells (H7) and necrotic areas (TS1). The therapeutic approach using 125I labeled antibodies is encouraging and may offer new dimensions in radioimmunotherapy.
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| 1046. |
- Riklund, Katrine, et al.
(författare)
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Radioimmunodetection of ovarian cancer.
- 1993
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 32:7-8, s. 729-734
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Tidskriftsartikel (refereegranskat)abstract
- Radioimmunoscintigraphy (RIS) is a potentially valuable method for the detection of primary, secondary and recurrent malignant tumours. Antigens that have been used for monitoring as well as for RIS of ovarian carcinomas include CA 125, PLAP, HMFG, and CA 19-9. Between 70 and 100% of the tumours have been detected at RIS when these antigens have been used. Conventional methods, e.g., computerized tomography (CT) and ultrasonography (US), demonstrate similar or lower detection rate than RIS for tumour diagnosis. RIS gives additional information to conventional radiological methods (CT and US) for the detection of occult ovarian carcinomas. A review of earlier investigations is given and our own recent results using PLAP as a target antigen are presented. The future potential of the technology is discussed.
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| 1047. |
- Riklund, Katrine, et al.
(författare)
-
Radioimmunoscintigraphy of gynecologic tumors with 131I-labeled anti-PLAP monoclonal antibodies.
- 1991
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Ingår i: Acta Radiologica. - 0284-1851 .- 1600-0455. ; 32:5, s. 375-380
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Tidskriftsartikel (refereegranskat)abstract
- Radioimmunoscintigraphy (RIS) was performed in 20 patients with gynecologic tumors, 14 ovarian, 5 cervical, and one endometrial carcinoma. One murine monoclonal antibody (mab) against placental alkaline phosphatase (H7) was used after radiolabeling with 131I. The labeling procedure yielded antibodies with specific activity varying between 60 and 73 MBq/mg mab. Each patient received 57 to 100 MBq of the preparation. RIS was performed 7 to 35 days later. Patients with ovarian adenocarcinoma had an accumulation of activity on RIS at tumor sites (79%, 11/14) verified by ultrasonography, CT, and clinical examination. A low or absent accumulation of activity was seen in patients with cervical tumors. The patient with an endometrial adenocarcinoma was seen to have an activity accumulation at RIS corresponding to tumor sites determined by ultrasound and/or CT. It is concluded that RIS using monoclonal antibodies against placental alkaline phosphatase can provide information which will supplement that gained from other investigations of patients with ovarian adenocarcinomas.
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| 1048. |
- Roper, D I, et al.
(författare)
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Preliminary crystallographic analysis of 4-oxalocrotonate tautomerase reveals the oligomeric structure of the enzyme.
- 1994
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Ingår i: Journal of Molecular Biology. - 0022-2836 .- 1089-8638. ; 243:4
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Tidskriftsartikel (refereegranskat)abstract
- Crystals of recombinant 4-oxalocrotonate tautomerase from Pseudomonas sp. strain CF600 have been obtained in a form suitable for X-ray analysis. The enzyme is a highly efficient catalyst and is unusual in that it consists of subunits of only 62 amino acids. It crystallises in the triclinic space group, P1, with unit cell dimensions a = 39.6 A, b = 51.5 A, c = 51.6 A, alpha = 60.0 degrees, beta = 81.4 degrees, gamma = 69.6 degrees. The crystals diffract to beyond 1.9 A resolution and are stable to irradiation with X-rays. Preliminary crystallographic data are not consistent with the previously suggested pentameric structure, but indicate that the complex is in fact a hexamer with 32 symmetry.
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| 1049. |
- Rosenquist, J B, et al.
(författare)
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Occlusion of the incisal canal with bone chips. A procedure to facilitate insertion of implants in the anterior maxilla.
- 1992
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Ingår i: International Journal of Oral and Maxillofacial Surgery. - 0901-5027 .- 1399-0020. ; 21:4, s. 210-211
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Tidskriftsartikel (refereegranskat)abstract
- In 4 patients, who had lost one or both central maxillary incisors due to trauma, the incisal canals were filled with autogenous cancellous bone harvested from the chin. After a healing period of 4-5 months implants were inserted. At the time of implant surgery in all cases the canal appeared to be replaced by cancellous bone and the implants were placed partially into the grafted area. After another 6 months abutments were connected and crowns made. After follow-up of between 12 and 15 months no fixture has been lost.
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| 1050. |
- Roson, Roberto, et al.
(författare)
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Production and trade in interacting economies : a survey of applied equilibrium models
- 1990
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A class of models for analyses of the interaction between economic structure and transportation system in spatially separated economies is discussed. The model class, applied multisector network equilibrium models (AMNE) is presented and existing models, such as Input–Output, CGE, ICGE, SPE and FNE models, are interpreted as special cases.Especially ICGE models and a set of linearized ICGE models are considered. This type of models will have an increasing importance in studies of infrastructure investments, in particular in the context of the integration process within the European Community.
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