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Träfflista för sökning "L773:1352 2310 ;pers:(Maione M.)"

Sökning: L773:1352 2310 > Maione M.

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1.
  • Fourier, C, et al. (författare)
  • A genetic CLOCK variant associated with cluster headache causing increased mRNA levels
  • 2018
  • Ingår i: Cephalalgia : an international journal of headache. - : SAGE Publications. - 1468-2982. ; 38:3, s. 496-502
  • Tidskriftsartikel (refereegranskat)abstract
    • Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene for cluster headache. Methods We performed an association study on a large Swedish cluster headache case-control sample (449 patients and 677 controls) screening for three single nucleotide polymorphisms (SNPs) in the CLOCK gene implicated in diurnal preference (rs1801260) or sleep duration (rs11932595 and rs12649507), respectively. We further wanted to investigate the effect of identified associated SNPs on CLOCK gene expression. Results We found a significant association with rs12649507 and cluster headache ( p = 0.0069) and this data was strengthened when stratifying for reported diurnal rhythmicity of attacks ( p = 0.0009). We investigated the effect of rs12649507 on CLOCK gene expression in human primary fibroblast cultures and identified a significant increase in CLOCK mRNA expression ( p = 0.0232). Conclusions Our results strengthen the hypothesis of the involvement of circadian rhythm in cluster headache.
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  • Monfared, Behzad, 1983-, et al. (författare)
  • Design and Test of a Domestic Heat Pump with Ammonia as Refrigerant
  • 2011
  • Ingår i: 4th IIR Conference. - France : International Institute of Refrigeration.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Among alternative refrigerants, ammonia with zero Ozone Depleting Potential (ODP) and Global Warming Potential (GWP), and favorable thermodynamic properties is a sensible choice as a replacement for the synthetic refrigerants, which are powerful greenhouse gases.In this paper, the results of experiments done on a new ammonia water-to-water heat pump prototype at different evaporation temperatures and compressor speeds are reported. The heat pump is designed to deliver 7 kW heat at evaporation temperature of -5°C and condensation temperature of 40°C. The hot discharge gas from compressor is utilized to provide sanitary hot water, and the rest of the heat is used for preheating the tap water and space heating of a single-family house. The compact design of the heat pump helps reducing the refrigerant charge. To reduce the charge further and to prevent oil accumulation at the bottom of evaporator, a minichannel aluminum heat exchanger is used as evaporator.
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