SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:gu ;mspu:(article);lar1:(cth)"

Sökning: LAR1:gu > Tidskriftsartikel > Chalmers tekniska högskola

  • Resultat 31-40 av 6761
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
31.
  • Abel, Frida, 1974, et al. (författare)
  • Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours.
  • 2002
  • Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 86:4, s. 596-604
  • Tidskriftsartikel (refereegranskat)abstract
    • The genes encoding Caspase-9 and DFF45 have both recently been mapped to chromosome region 1p36.2, that is a region alleged to involve one or several tumour suppressor genes in neuroblastoma tumours. This study presents an update contig of the 'Smallest Region of Overlap of deletions' in Scandinavian neuroblastoma tumours and suggests that DFF45 is localized in the region. The genomic organization of the human DFF45 gene, deduced by in-silico comparisons of DNA sequences, is described for the first time in this paper. In the present study 44 primary tumours were screened for mutation by analysis of the genomic sequences of the genes. In two out of the 44 tumours this detected in the DFFA gene one rare allele variant that caused a non-polar to a polar amino acid exchange in a preserved hydrophobic patch of DFF45. One case was hemizygous due to deletion of the more common allele of this polymorphism. Out of 194 normal control alleles only one was found to carry this variant allele, so in respect of it, no healthy control individual out of 97 was homozygous. Moreover, our RT-PCR expression studies showed that DFF45 is preferably expressed in low-stage neuroblastoma tumours and to a lesser degree in high-stage neuroblastomas. We conclude that although coding mutations of Caspase-9 and DFF45 are infrequent in neuroblastoma tumours, our discovery of a rare allele in two neuroblastoma cases should be taken to warrant further studies of the role of DFF45 in neuroblastoma genetics.
  •  
32.
  • Abel, Frida, 1974, et al. (författare)
  • Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24.
  • 1999
  • Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 81:8, s. 1402-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relation to known genetic alterations. Chromosome 17 status was detected by fluorescence in situ hybridization (FISH). Thirty-one of the 48 neuroblastomas (65%) showed 17q gain, and this was significantly associated with poor prognosis. As previously reported, 17q gain was significantly associated with metastatic stage 4 neuroblastoma and more frequently detected than both deletion of chromosome arm 1p and MYCN amplification in tumours of all stages. 17q gain also showed a strong correlation to survival probability (P = 0.0009). However, the most significant correlation between 17q gain and survival probability was observed in children with low-stage tumours (stage 1, 2, 3 and 4S), with a survival probability of 100% at 5 years from diagnosis for children with tumours showing no 17q gain compared to 52.5% for those showing 17q gain (P = 0.0021). This suggests that 17q gain as a prognostic factor plays a more crucial role in low-stage tumours. Expression of the somatostatin receptor 2 (SSTR2), localized in chromosome region 17q24, has in previous studies been shown to be positively related to survival in neuroblastoma. A point mutation in the SSTR2 gene has earlier been reported in a human small-cell lung cancer. In this study, mutation screening of the SSTR2 gene in 43 neuroblastoma tumours was carried out with polymerase chain reaction-based single-stranded conformation polymorphism/heteroduplex (SSCP/HD) and DNA sequencing, and none of the tumours showed any aberrations in the SSTR2 gene. These data suggest that mutations in the SSTR2 gene are uncommon in neuroblastoma tumours and do not correlate with either the 17q gain often seen or the reason some tumours do not express SSTR2 receptors. Overall, this study indicates that gain of chromosome arm 17q is the most frequently occurring genetic alteration, and that it is associated with established prognostic factors.
  •  
33.
  • Abel, Frida, 1974, et al. (författare)
  • Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.
  • 2005
  • Ingår i: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 0959-8049. ; 41:4, s. 635-46
  • Tidskriftsartikel (refereegranskat)abstract
    • It has been proposed that a lack of apoptosis plays an important role in neuroblastoma (NB) progression. We therefore screened cDNA array filters, including 198 apoptotic genes, in order to identify mRNA transcripts that are differentially expressed in tumours with unfavourable versus favourable biology. Twenty-one genes were analysed further using real-time reverse-transcriptase-polymerase chain reaction (RT-PCR). Significantly lower levels of DNCL1 (PIN; P(c)(corrected) = 0.0054) and NTRK1 (TrkA; P(c) = 0.039) were found in NB tumours with unfavourable biology. In addition, BID, BCL2, APAF1, CASP2, CASP3 and CASP9 were found to be preferentially expressed in tumours with favourable biology, whereas CDKN1A (p21), IL2RA, and MCL1, were found to be preferentially expressed in NB tumours with unfavourable biology. In conclusion, mRNA levels of transcripts encoding pro-apoptotic mediators of the mitochondrial apoptotic pathway were found to be expressed to a lower extent in tumours with unfavourable biology. Our data also suggest that the mitochondrial pathway is suppressed in advanced stages of NB tumours, due to an imbalance between anti-apoptotic and pro-apoptotic mediators which is a finding that may have therapeutic significance.
  •  
34.
  • Abel, Frida, 1974, et al. (författare)
  • Mutations in the N-terminal domain of DFF45 in a primary germ cell tumor and in neuroblastoma tumors.
  • 2004
  • Ingår i: International journal of oncology. - 1019-6439 .- 1791-2423. ; 25:5, s. 1297-302
  • Tidskriftsartikel (refereegranskat)abstract
    • DFF45 has essential functions in the final stage of apoptosis by acting both as a folding chaperone and a DNase inhibitor of DFF40. The gene encoding DFF45 (DFFA) maps to the consensus deleted region in primary neuroblastoma (NB; 1p36.2-3) and within the homozygously deleted region in an NB cell line (1p36.2). DFF45 is therefore an attractive candidate NB tumor suppressor. In a previous study we found a rare allele variant, causing a non-polar to a polar amino acid exchange (Ile69Thr) in a preserved hydrophobic patch of DFF45, and we also found DFFA to be preferentially expressed in favorable NB tumors. We have extended the previous study and performed mutation analyses in another 56 NB tumors (100 in total) as well as a set of other tumors for coding mutations in DFFA. We have also performed studies of the DFFA expression in tumors using real-time PCR. We found a missense mutation (Ile15Met) in the remaining allele of a teratoma with heterozygous deletion of 1p, and a three base-pair deletion in an NB of unknown stage causing a deletion of amino acid 37 in DFF45. The one-base substitution detected in the teratoma was not present in the patients constitutional DNA, i.e. it is a true mutation present in the tumor DNA only. In conclusion, three different coding alterations have been found in the region encoding the N-terminal regulatory domain of DFF45, responsible for binding and achieving its chaperone and inhibitor functions on other proteins. Moreover, by real-time RT-PCR expression study, we found the mRNA level of DFFA to be significantly (p=0.038) reduced by a factor of 1.7 times in NB tumors of unfavorable outcome.
  •  
35.
  • Abenius, Tobias, 1979, et al. (författare)
  • System-scale network modeling of cancer using EPoC
  • 2012
  • Ingår i: Advances in Experimental Medicine and Biology. - New York, NY : Springer New York. - 0065-2598. - 9781441972095 ; 736:5, s. 617-643
  • Tidskriftsartikel (refereegranskat)abstract
    • One of the central problems of cancer systems biology is to understand the complex molecular changes of cancerous cells and tissues, and use this understanding to support the development of new targeted therapies. EPoC (Endogenous Perturbation analysis of Cancer) is a network modeling technique for tumor molecular profiles. EPoC models are constructed from combined copy number aberration (CNA) and mRNA data and aim to (1) identify genes whose copy number aberrations significantly affect target mRNA expression and (2) generate markers for long- and short-term survival of cancer patients. Models are constructed by a combination of regression and bootstrapping methods. Prognostic scores are obtained from a singular value decomposition of the networks. We have previously analyzed the performance of EPoC using glioblastoma data from The Cancer Genome Atlas (TCGA) consortium, and have shown that resulting network models contain both known and candidate disease-relevant genes as network hubs, as well as uncover predictors of patient survival. Here, we give a practical guide how to perform EPoC modeling in practice using R, and present a set of alternative modeling frameworks.
  •  
36.
  • Aberšek, Nina, et al. (författare)
  • Calprotectin levels in amniotic fluid in relation to intra-amniotic inflammation and infection in women with preterm labor with intact membranes: A retrospective cohort study
  • 2022
  • Ingår i: European Journal of Obstetrics & Gynecology and Reproductive Biology. - : Elsevier BV. - 1872-7654 .- 0301-2115. ; 272, s. 24-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To evaluate the concentrations of calprotectin in amniotic fluid with respect to intra-amniotic inflammation and infection and to assess the presence or absence of bacteria in the amnio-chorionic niche with respect to presence or absence of intra-amniotic inflammation. Study design: Seventy-nine women with singleton pregnancies and preterm labor with intact membranes (PTL) were included in the study. Amniotic fluid was collected at the time of admission by amniocentesis and calprotectin levels were analyzed from frozen/thawed samples using ELISA. Interleukin (IL)-6 concentration was measured by point-of-care test. Samples from amniotic fluid and the amnio-chorionic niche (space between amniotic and chorionic membranes) were microbiologically analyzed. Microbial invasion of the amniotic cavity (MIAC) was diagnosed based on a positive PCR result for Ureaplasma species, Mycoplasma hominis, 16S rRNA or positive culture. Intra-amniotic inflammation (IAI) was defined as amniotic fluid point-of-care IL-6 concentration ≥ 745 pg/mL. The cohort of included women was divided into 4 subgroups based on the presence or absence of IAI/MIAC; i) intra-amniotic infection, ii) sterile IAI, iii) intra-amniotic colonization and iv) neither MIAC nor IAI. Results: Women with intra-amniotic infection had a significantly higher intra-amniotic calprotectin concentration (median; 101.6 µg/mL) compared with women with sterile IAI (median; 9.2 µg/mL), women with intra-amniotic colonization (median; 2.6 µg/mL) and women with neither MIAC nor IAI (median 4.6 µg/mL) (p = 0.001). Moreover, significantly higher amniotic fluid calprotectin concentration was seen in women who delivered within 7 days (p = 0.003). A significant negative correlation was found between amniotic fluid calprotectin and gestational age at delivery (rho = 0.32, p = 0.003). Relatively more bacteria in the amnio-chorionic niche were found in the sterile IAI group compared with the other groups. Conclusions: Calprotectin concentrations in amniotic fluid were significantly higher in the intra-amniotic infection group compared with the other groups. Moreover, the bacterial presence in the amnio-chorionic niche was higher in IAI group.
  •  
37.
  • Abrahamsson, Christoffer, 1984, et al. (författare)
  • Magnetically induced structural anisotropy in binary colloidal gels and its effect on diffusion and pressure driven permeability
  • 2014
  • Ingår i: Soft Matter. - 1744-683X .- 1744-6848. ; 10:24, s. 4403-4412
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the synthesis, microstructure and mass transport properties of a colloidal hydrogel selfassembled from a mixture of colloidal silica and nontronite clay plates at different particle concentrations. The gel-structure had uniaxial long-range anisotropy caused by alignment of the clay particles in a strong external magnetic field. After gelation the colloidal silica covered the clay particle network, fixing the orientation of the clay plates. Comparing gels with a clay concentration between 0 and 0.7 vol%, the magnetically oriented gels had a maximum water permeability and self-diffusion coefficient at 0.3 and 0.7 vol% clay, respectively. Hence the specific clay concentration resulting in the highest liquid flux was pressure dependent. This study gives new insight into the effect of anisotropy, particle concentration and bound water on mass transport properties in nano/microporous materials. Such findings merit consideration when designing porous composite materials for use in for example fuel cell, chromatography and membrane technology.
  •  
38.
  • Abrahamsson, Erik, 1974, et al. (författare)
  • A new reaction path for the C + NO reaction: dynamics on the 4A'' potential-energy surface.
  • 2008
  • Ingår i: Physical chemistry chemical physics : PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 10:30, s. 4400-9
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new reaction path without significant barriers for the C + NO reaction, forming ground state N((4)S) and CO. Electronic structure (CASPT2) calculations have been performed for the two lowest (4)A'' states of the CNO system. The lowest of these states shows no significant barriers against reaction in the C + NO or O + CN channels. This surface has been fitted to an analytical function using a many-body expansion. Using this surface, and the previously published (2)A' and (2)A'' surfaces [Andersson et al., Phys. Chem. Chem. Phys., 2000, 2, 613; Andersson et al., Chem. Phys., 2000, 259, 99], we have performed quasiclassical trajectory (QCT) calculations, obtaining rate coefficients for the C((3)P) + NO(X(2)Pi) --> CO(X(1)Sigma(+)) + N((4)S,(2)D) and C((3)P) + NO(X(2)Pi) --> O((3)P) + CN(X(2)Sigma(+)) reactions. We have also simulated the crossed molecular beam experiments of Naulin et al. [Chem. Phys., 1991, 153, 519] The inclusion of the (4)A'' surface in the QCT calculations gives excellent agreement with experiments. This is the first time an adiabatic pathway from C((3)P) + NO(X(2)Pi) to CO(X(1)Sigma(+))+N((4)S) has been reported.
  •  
39.
  • Abrahamsson, Erik, 1974, et al. (författare)
  • Classical and quantum dynamics of the O+CN reaction
  • 2006
  • Ingår i: Chemical Physics. - : Elsevier BV. - 0301-0104. ; 324:2-3, s. 507-514
  • Tidskriftsartikel (refereegranskat)abstract
    • Electronic structure (CASPT2) calculations have been performed for the (2)Pi and (4)Sigma(-) states of the NCO system. To create the potential energy surfaces, the generalized discrete variable representation (GDVR) method has been used. Wave packet calculations have been performed for the collinear O + CN reaction on both surfaces. These are the first reported quantum dynamics calculations on this reaction. State-to-state reaction probabilities are presented. On the (2)Pi surface, which has an almost 6 eV deep well, we obtain structure in the reaction probabilities at low kinetic energies but at higher energies they are smooth. The (4)Sigma(-) surface is highly exoergic and vibrationally non-adiabatic dynamics is observed. The (4)Sigma(-) surface has an early barrier and as a result we find that translational energy more efficiently promotes the reaction than vibrational energy does. The wave packet results are compared with QCT results. Generally the agreement is good as would be expected but some notable differences are found, particularly for reaction out of the vibrational ground state. (c) 2005 Elsevier B.V. All rights reserved.
  •  
40.
  • Abrahamsson, Erik, 1974, et al. (författare)
  • Dynamics of the O + CN Reaction and N + CO Scattering on Two Coupled Surfaces
  • 2009
  • Ingår i: J. Phys. Chem. A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 113:52, s. 14824-14830
  • Tidskriftsartikel (refereegranskat)abstract
    • Spin−orbit coupling between the two collinear 2Π and 4Σ− potential energy surfaces for the NCO system are calculated using the RASSI method with CASSCF wave functions as basis set. The GDVR method has been used to interpolate a spin−orbit coupling surface. Wave packet and quasi-classical trajectory surface hopping calculations have been performed and compared for both the O(3P) + CN(X2Σ+) → N(4S) + CO(X1Σ+) reaction and for electronically inelastic scattering in the N + CO channels. The O + CN nonadiabatic reaction probabilities are small. The wavepacket study gives a resonance structure. Also for the N + CO electronically inelastic scattering the wave packet calculations give a distinct resonance structure with peak transition probabilities up to around 10%, which is somewhat lower than the trajectory surface hopping results.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 31-40 av 6761
Typ av publikation
Typ av innehåll
refereegranskat (6500)
övrigt vetenskapligt/konstnärligt (257)
populärvet., debatt m.m. (4)
Författare/redaktör
Nilsson, Staffan, 19 ... (249)
Kristiansson, Erik, ... (135)
Odén, Anders, 1942 (114)
Nielsen, Jens B, 196 ... (94)
Ewing, Andrew G, 195 ... (91)
Sandberg, Ann-Sofie, ... (88)
visa fler...
Wijk, Helle, 1958 (88)
Ahlberg, Elisabet, 1 ... (83)
Häggström, Olle, 196 ... (83)
Hohmann, Stefan, 195 ... (82)
Patriksson, Michael, ... (82)
Pedersen, Karsten, 1 ... (77)
Borén, Jan, 1963 (72)
Malmberg, Per, 1974 (70)
Styhre, Alexander, 1 ... (59)
Zhang, Genkai, 1963 (56)
Larsson, D. G. Joaki ... (55)
Beilina, Larisa, 197 ... (55)
Särkkä, Aila, 1962 (51)
Coquand, Thierry, 19 ... (49)
Wennberg, Bernt, 196 ... (49)
Zetterberg, Henrik, ... (48)
Johansson, Helena, 1 ... (48)
Hermansson, Malte, 1 ... (48)
Sagitov, Serik, 1956 (47)
Adiels, Martin, 1976 (46)
Larsson, Stig, 1952 (46)
Shekhter, Robert I., ... (45)
Albinsson, Ingvar, 1 ... (44)
Gorelik, Leonid, 195 ... (44)
Ohlsson, Claes, 1965 (43)
Mellander, Bengt-Eri ... (43)
Asadzadeh, Mohammad, ... (42)
Barman, Malin, 1983 (41)
Gerlee, Philip, 1980 (41)
Lundh, Torbjörn, 196 ... (40)
Undeland, Ingrid, 19 ... (39)
Nerman, Olle, 1951 (39)
Rosengren, Hjalmar, ... (38)
Jagers, Peter, 1941 (38)
Campbell, Eleanor E ... (38)
Wold, Agnes E, 1955 (37)
Höök, Fredrik, 1966 (37)
Hanstorp, Dag, 1960 (37)
Sjögren, Peter, 1948 (37)
Nilsson, R. Henrik, ... (36)
Andersson, Mats, 195 ... (36)
Jonson, Mats, 1947 (36)
Rozenblioum, Grigori ... (36)
Andreasson, Håkan, 1 ... (36)
visa färre...
Lärosäte
Göteborgs universitet (6761)
Lunds universitet (309)
Karolinska Institutet (278)
Uppsala universitet (265)
Kungliga Tekniska Högskolan (188)
visa fler...
Linköpings universitet (173)
RISE (155)
Umeå universitet (153)
Stockholms universitet (64)
Högskolan i Borås (63)
Sveriges Lantbruksuniversitet (46)
Jönköping University (41)
Högskolan i Skövde (38)
Luleå tekniska universitet (35)
Örebro universitet (31)
Linnéuniversitetet (26)
Mälardalens universitet (24)
Högskolan i Halmstad (21)
Malmö universitet (20)
Blekinge Tekniska Högskola (15)
Högskolan Väst (12)
Karlstads universitet (12)
IVL Svenska Miljöinstitutet (11)
Högskolan i Gävle (10)
Mittuniversitetet (10)
Högskolan Dalarna (9)
VTI - Statens väg- och transportforskningsinstitut (9)
Högskolan Kristianstad (4)
Marie Cederschiöld högskola (4)
Södertörns högskola (3)
Sophiahemmet Högskola (3)
Gymnastik- och idrottshögskolan (2)
Naturhistoriska riksmuseet (2)
Konstfack (1)
Handelshögskolan i Stockholm (1)
visa färre...
Språk
Engelska (6633)
Svenska (120)
Kinesiska (3)
Franska (2)
Odefinierat språk (1)
Polska (1)
visa fler...
Nederländska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Naturvetenskap (4834)
Medicin och hälsovetenskap (1761)
Teknik (1216)
Samhällsvetenskap (627)
Humaniora (162)
Lantbruksvetenskap (147)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy