| 41. |
- Aakre, K. M., et al.
(författare)
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Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers
- 2022
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Ingår i: Clinical chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 68:8, s. 1022-1030
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Tidskriftsartikel (refereegranskat)abstract
- The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac biomarkers in clinical laboratories and practice. The committee's goals are to improve the understanding of certain key analytical and clinical aspects of cardiac biomarkers and how these may interplay in clinical practice. Measurement of high-sensitivity cardiac troponin (hs-cTn) assays is a cornerstone in the clinical evaluation of patients with symptoms and/or signs of acute cardiac ischemia. To define myocardial infarction, the Universal Definition of Myocardial Infarction requires patients who manifest with features suggestive of acute myocardial ischemia to have at least one cTn concentration above the sex-specific 99th percentile upper reference limit (URL) for hs-cTn assays and a dynamic pattern of cTn concentrations to fulfill the diagnostic criteria for MI. This special report provides an overview of how hs-cTn 99th percentile URLs should be established, including recommendations about prescreening and the number of individuals required in the reference cohort, how statistical analysis should be conducted, optimal preanalytical and analytical protocols, and analytical/biological interferences or confounds that can affect accurate determination of the 99th percentile URLs. This document also provides guidance and solutions to many of the issues posed.
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| 42. |
- Aakre, Kristin M, et al.
(författare)
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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
- 2024
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Ingår i: Clinical chemistry. - 0009-9147 .- 1530-8561. ; 70:3, s. 497-505
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Tidskriftsartikel (refereegranskat)abstract
- Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but require reporting cardiac troponin concentrations at low concentrations that are sometimes below the limit of quantification. Whether analytical imprecision at these concentrations contributes to misclassification of patients is debated.The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers (IFCC C-CB) provides evidence-based educational statements on analytical and clinical aspects of cardiac biomarkers. This mini-review discusses how the reporting of low concentrations of cardiac troponins impacts on whether or not assays are classified as high-sensitivity and how analytical performance at low concentrations influences the utility of troponins in accelerated diagnostic pathways. Practical suggestions are made for laboratories regarding analytical quality assessment of cardiac troponin results at low cutoffs, with a particular focus on accelerated diagnostic pathways. The review also discusses how future use of cardiac troponins for long-term prediction or management of cardiovascular disease may require improvements in analytical quality.Clinical guidelines recommend using cardiac troponin concentrations as low as the limit of detection of the assay to guide patient care. Laboratories, manufacturers, researchers, and external quality assessment providers should extend analytical performance monitoring of cardiac troponin assays to include the concentration ranges applicable in these pathways.
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| 43. |
- Aakvaag, Gunnar, et al.
(författare)
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Introduction
- 2012
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Ingår i: Introduction to Sociology. Scandinavian Sensibilities, Editors, Aakvag, Jacobsen and Johansson. - Harlow : Pearson. - 9780273727392
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 44. |
- Aalberg, Toril, et al.
(författare)
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Strategy and Game Framing
- 2017
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Ingår i: Comparing Political Journalism - (eds.) Claes de Vreese, Frank Esser & David Nicolas Hopmann. - New York : Routledge. - 9781138655867 ; , s. 33-49
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Bokkapitel (refereegranskat)
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| 45. |
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| 46. |
- Aalders, Johannes Theodor, et al.
(författare)
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Blogal Studies in 2020 and Beyond
- 2020
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Ingår i: School of Blogal Studies.
-
Annan publikation (övrigt vetenskapligt/konstnärligt)
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| 47. |
- Aalders, Johannes Theodor
(författare)
-
Building on the ruins of empire: the Uganda Railway and the LAPSSET corridor in Kenya
- 2021
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Ingår i: Third World Quarterly. - : Informa UK Limited. - 0143-6597 .- 1360-2241. ; 42:5, s. 996-1013
-
Tidskriftsartikel (refereegranskat)abstract
- This article explores colonial (dis-)continuities between the planned Lamu Port–South Sudan–Ethiopia Transport (LAPSSET) development corridor and the Uganda Railway (UR). The historical approach to infrastructure studies highlights the effects of large-scale infrastructures beyond their immediate material impact, and reveals their potential power to structure mobilities, historicities and politics of scale. With reference to relational theories, it is argued that the two projects gain their respective significance not only through their ability to connect distant places, but also by blocking and severing other competing ways of being mobile. Particularly, both infrastructure projects create technologies enabling easier and faster flow of capital and commodities but limit previously prevalent mobilities practised by caravans and semi-nomadic people in the region. Both projects, furthermore, produce particular ways of remembering the past and anticipating the future. The article identifies a major discontinuity in the politics of scale they respectively imply: while the UR aimed at producing a clear scalar hierarchy between empire and colony, the LAPSSET alleges to dissolve hard boundaries between scalar instances. This article is based on qualitative data collected during fieldwork along the proposed route of the LAPSSET corridor, as well as archive work regarding the UR.
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| 48. |
- Aalders, Johannes Theodor, et al.
(författare)
-
Drawing together: Making Marginal Futures Visible through Collaborative Comic Creation (CCC)
- 2020
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Ingår i: Geographica Helvetica. The Swiss Journal of Geography. - : Copernicus GmbH. - 0016-7312. ; 75, s. 415-430
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Tidskriftsartikel (refereegranskat)abstract
- The article introduces collaborative comic creation (CCC) as a methodological tool. The central question it addresses is how marginalised imaginations of futures can be made visible in the context of the planned Lamu Port-South Sudan-Ethiopia-Transport (LAPSSET) in Kenya. The question assumes that infrastructure projects such as the LAPSSET corridor inscribe not only particular ways of moving into a landscape but also one specific temporality that marginalises other future-making practices. The paper participates in the ongoing debate about how imagined futures and future-making practices can be appreciated and analysed methodologically. It thus contributes to the literature on geographies of the future by drawing together conceptual insights from anthropology, infrastructure studies, and critical cartography. Based on these different approaches, the paper proposes to regard future-making practices not only in relation to contentious timelines but also in terms of lines made by moving and drawing on landscapes and surfaces. Using a review of existing social foresight methods as a basis, we describe the practical implementation of CCC. Subsequently, the analysis of one collaboratively produced comic illustrates how the method can help to visualise ambivalent and uncertain imaginations of different futures that oppose the unitary vision of modernity produced by dominant infrastructural visions of a single future. We conclude by reflecting on possible ways of developing the method further.
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| 49. |
- Aalders, Johannes Theodor
(författare)
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Ghostlines: Movements, Anticipations, and Drawings of the LAPSSET Development Corridor in Kenya
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Lamu Port-South Sudan-Ethiopia-Transport (LAPSSET) corridor is a partly completed development corridor in Kenya that will connect the eponymous places via roads, pipelines and railway lines, if completed. This thesis investigates how inhabitants of the traversed area navigate and shape the spatio-temporal landscape of the corridor, following three motifs: lines created through moving, anticipating, and drawing. Under moving, the thesis explores people’s encounters of LAPSSET as connection, obstacle, and repulsion, relying on mobile ethnography. In anticipating, the thesis introduces ‘spectral landscapes of anticipation’ to investigate different temporalities people create in relation to the corridor. In drawing, it considers ways of visualizing and envisioning infrastructure projects and introduces Collaborative Comic Creation as a possibility to cut through the visual normativity of infrastructural megaprojects.
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| 50. |
- Aalders, Johannes Theodor, et al.
(författare)
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The Making and Unmaking of a Megaproject: Contesting Temporalities along the LAPSSET Corridor in Kenya
- 2021
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Ingår i: Antipode. - : Wiley. - 0066-4812 .- 1467-8330. ; 53:5, s. 1273-1293
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we show how communities in Northern Kenya proactively engage an unfolding megaproject and the temporalities it evokes—the Lamu Port South Sudan Ethiopia Transport Corridor (LAPSSET). We argue that the latitude communities have in contending with megaprojects is broader and more dynamic than passive reception of or outright resistance against the futures promised. By introducing the concepts of entangling and fraying, we emphasise the agency communities create for themselves by appreciating their strategies and expressions of stabilising or troubling the “megaproject”. While entangling refers to practices through which communities attach additional features to an otherwise rather stable vision of its “meganess”, fraying, in contrast, describes the strands that splice off towards different spatio‐temporal imaginaries. We discuss these practices in four instances of engaging LAPSSET: constructing temporary homes at project sites; engaging in land reform; disputing land acquisition at oil exploration sites; and contesting a planned resort city.
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